Abstract: Systems, apparatuses, and methods for controlling a gastric band in response to the detection of eating in a subject. The band is positioned in a subject around the subject's stomach. In one method, the band is adjusted in response to changes in electrical activity of the subject's lower esophageal sphincter. Changes in electrical activity can be monitored by a monitoring unit, which can send signals to the band to open or close depending on the changes in electrical activity.

Abstract: Systems, apparatuses, and methods for delivery of an active agent in response to the changes in electrical activity of a subject's lower esophageal sphincter. Changes in electrical activity can be monitored by a monitoring unit containing a microprocessor. A reservoir and pump can be used to store and release the active agent. The active agent can be cholecystokinin, peptide YY, glucagon-like peptide 1 or 2, and ghrelin, or a combination thereof.

Abstract: A system, apparatus, and method for controlling a gastric band in response to the detection of eating in a subject. The system includes an inflatable/deflatable gastric hand, a monitoring unit that monitors electrical activity changes of the subject's lower esophageal sphincter, and a hydraulic system that moves fluid into and out of the gastric band in response to a signal from the monitoring unit about the electrical activity changes. The method includes moving fluid into and out of an inflatable/deflatable gastric band in response to changes in electrical activity of the subject's lower esophageal sphincter.

Abstract: The present specification describes methods and devices using electrical stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD).

Abstract: The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders.

Abstract: The present specification describes methods and devices using electrical stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD).

Abstract: The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders.

Abstract: The present invention describes methods and devices using low frequency electrical stimulation or neural high frequency stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD).

Abstract: The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders.

Abstract: A method of detecting food or drink intake in a subject by placing one or more electrodes in contact with or proximate to the subject's lower esophageal sphincter (LES), and identifying food or drink intake by monitoring electrical activity in or proximate to the LES using the one or more electrodes. The present invention also provides a device and a system for automatically detecting food or drink intake.

Abstract: The present invention describes methods and devices using low frequency electrical stimulation or neural high frequency stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD).