Patents by Inventor Efstratios Neokosmidis

Efstratios Neokosmidis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR STABILIZING AN ISOTHIOCYANATE
    Publication number: 20230150932
    Abstract: The present invention relates to stable compositions comprising an isothiocyanate. It also relates to methods for stabilizing an isothiocyanate. According to the invention, sulforaphane is stabilized in the presence of fatty acids. Compositions prepared by mixing sulforaphane with certain amounts of a fatty acid or a mixture of fatty acids exhibit a stabilizing effect with respect to residual sulforaphane. It was found that such compositions can maintain sulforaphane, as expressed by % w/w, more effectively, i.e. stabilize it, compared to neat sulforaphane, under certain storage conditions. This facilitates the distribution of sulforaphane as a component to be used for industrial purposes, for example in the preparation of various products, dietary supplements, food additives, pharmaceuticals, nutraceuticals, cosmetics etc, because it makes long-term storage easier and efficient.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 18, 2023
    Inventors: V. Theocharis KOFTIS, Efstratios NEOKOSMIDIS, L. Petros GZIKIS, Sakellarios TRAKOSSAS, Savvas THYSIADIS, Theodoros PANAGIOTIDIS, Thanos AANDREOU, Elli VASTARDI, Evanthia TOLIKA, Foteini ATHANASIADOU
  • METHOD FOR DEODORIZING ALGAE
    Publication number: 20220362412
    Abstract: A non-destructive and reversible process to deodorize Nannochloropsis algae is provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: November 17, 2022
    Inventors: Theocharis V. KOFTIS, Efstratios NEOKOSMIDIS, Michael TERZIDIS, Theodoros PANAGIOTIDIS, Thanos ANDREOU, Elli VASTARDI, Foteini ATHANASIADOU
  • One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
    Patent number: 11198671
    Abstract: The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: December 14, 2021
    Assignee: VIO AG PHARMACEUTICALS S.A.
    Inventors: Theocharis V. Koftis, Efstratios Neokosmidis, Thanos Andreou, Petros Gkizis, Alexandra Lithadioti
  • A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL
    Publication number: 20210253513
    Abstract: The present invention relates to a novel process for the preparation of Tapentadol and intermediate compound 2R,3R)-3-(-methoxyphenyl)-N,N,2-trimethylpentanamine (compound of formula IIa).
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Applicant: PHARMATHEN S.A.
    Inventors: V. Theocharis KOFTIS, Efstratios NEOKOSMIDIS, Christos STATHAKIS, Petros GKIZIS, Theodoros PANAGIOTIDIS
  • Process for preparing biodegradable polymers of high molecular weight
    Patent number: 11046810
    Abstract: A novel method for the preparation of biodegradable polymers is disclosed. The method produces polymers of high molecular weight and particularly allows for stirring throughout the polymerization reaction.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: June 29, 2021
    Assignee: PHARMATHEN S.A.
    Inventors: V. Theocharis Koftis, Efstratios Neokosmidis, Konstantina Karidi, Anastasia-Aikaterini Varvogli
  • A ONE-POT ORGANO-PSEUDOCATALYTIC C-H ACTIVATION APPROACH FOR THE PREPARATION OF VORTIOXETINE AND VORTIOXETINE INTERMEDIATE
    Publication number: 20210163407
    Abstract: The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
    Type: Application
    Filed: June 19, 2019
    Publication date: June 3, 2021
    Applicant: VIO AG PHARMACEUTICALS S.A.
    Inventors: THEOCHARIS V. KOFTIS, EFSTRATIOS NEOKOSMIDIS, THANOS ANDREOU, PETROS GKIZIS, ALEXANDRA LITHADIOTI
  • PROCESS FOR PREPARING BIODEGRADABLE POLYMERS OF HIGH MOLECULAR WEIGHT
    Publication number: 20190315913
    Abstract: A novel method for the preparation of biodegradable polymers is disclosed. The method produces polymers of high molecular weight and particularly allows for stirring throughout the polymerization reaction.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 17, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: V. THEOCHARIS KOFTIS, EFSTRATIOS NEOKOSMIDIS, KONSTANTINA KARIDI, ANASTASIA-AIKATERINI VARVOGLI
  • Process for the preparation of a propenal intermediate and derivatives thereof
    Patent number: 8575343
    Abstract: The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: November 5, 2013
    Assignee: Pharmathen S.A.
    Inventors: Theoharis V. Koftis, Thanos Andreou, Aristotelis Menisiou, Efstratios Neokosmidis, Asteria Zitrou
  • PROCESS FOR THE PREPARATION OF PROPENAL INTERMEDIATE AND DERIVATIVES THEREOF
    Publication number: 20130066074
    Abstract: The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin.
    Type: Application
    Filed: June 7, 2010
    Publication date: March 14, 2013
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Thanos Andreou, Aristotelis Menisiou, Efstratios Neokosmidis, Asteria Zitrou
  • PROCESS FOR THE PREPARATION OF (R)-2-(3-DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4METHYLPHENOL AND SALTS THEREOF
    Publication number: 20120041235
    Abstract: The present invention relates to an improved process for the preparation of Tolterodine or salts thereof, which comprises the use of 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl methane sulfonate.
    Type: Application
    Filed: February 17, 2009
    Publication date: February 16, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Efstratios Neokosmidis, Rohit Ravikant Soni, Panagiota Mandalou, Aristotelis Menisiou