Abstract: In one example embodiment, an analysis application is used to optimize water quality sensor placement in a water distribution network by implementing a two-part optimization solution procedure, involving building an impact database, and determining an optimized water quality sensor location set using the impact database. The optimized sensor location set may indicate locations that maximize a length of pipes where water quality variations are detectable by at least one water quality sensor. Pipe wall reaction coefficients may be used as calibration parameters, with water quality indicated to be detectable at a possible sensor location when a change in its pipe wall reaction coefficients leads to a change in water quality at the possible sensor location that is greater than a threshold.