Patents by Inventor Ehud Marom

Ehud Marom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
    Patent number: 8377885
    Abstract: Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the present invention provides a long acting pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: February 19, 2013
    Assignee: Mapi Pharma Ltd.
    Inventors: Ehud Marom, Shai Rubnov
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20130023570
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 24, 2013
    Applicant: MAPI PHARMA LIMITED
    Inventor: Ehud MAROM
  • PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES
    Publication number: 20120296101
    Abstract: The present invention relates to a process for the preparation of darunavir, a nonpeptide protease inhibitor (PI), useful for the treatment of HIV/AIDS patients harboring multidrug-resistant HIV-1 variants that do not respond to previously existing HAART regimens. The present invention further relates to processes for the stereo-directed preparation of darunavir intermediates, in particular (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol and to certain novel intermediates obtained by such processes.
    Type: Application
    Filed: January 24, 2011
    Publication date: November 22, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Michael Mizhiritskii, Ehud Marom
  • INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS
    Publication number: 20120283463
    Abstract: The present invention discloses processes for the preparation of 3-[(1R,2R)-3-(dimethyl-amino)-1-ethyl-2-methyl-propyl]phenol (Tapentadol), salts thereof and related compounds of formula (A), including stereoisomers and pharmaceutically acceptable salts thereof, and to certain intermediates used in such process.
    Type: Application
    Filed: December 26, 2010
    Publication date: November 8, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Michael Mizhiritskii
  • PROCESSES FOR THE PREPARATION OF DEFERASIROX, AND DEFERASIROX POLYMORPHS
    Publication number: 20120245361
    Abstract: The present invention relates to processes for the preparation of deferasirox, an oral iron chelator developed to treat iron overload due to e.g. multiple blood transfusions. The present invention further provides novel deferasirox pseudopolymorphs and a novel amorphous form of deferasirox, processes for their preparation, as well as pharmaceutical compositions comprising same, and use thereof in treating iron overload.
    Type: Application
    Filed: January 28, 2010
    Publication date: September 27, 2012
    Applicant: MAPI PHARMA HK LIMITED
    Inventors: Michael Mizhiritskii, Ehud Marom, Shai Rubnov
  • DEPOT SYSTEMS COMPRISING GLATIRAMER OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120164229
    Abstract: The present invention provides long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer. In particular, the present invention provides a long acting pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.
    Type: Application
    Filed: February 29, 2012
    Publication date: June 28, 2012
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud MAROM, Shai RUBNOV
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20120035142
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: December 8, 2009
    Publication date: February 9, 2012
    Applicant: MAPI Pharma Limited
    Inventor: Ehud Marom
  • PROCESS FOR THE PREPARATION OF ALOGLIPTIN
    Publication number: 20120029000
    Abstract: The present invention is based on the discovery of a process for preparing pyrimidin-dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).
    Type: Application
    Filed: March 25, 2010
    Publication date: February 2, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Michael Mizhiritskii, Shai Rubnov
  • DEPOT SYSTEMS COMPRISING GLATIRAMER OR A PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120015891
    Abstract: The present invention provides long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer. In particular, the present invention provides a long acting pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.
    Type: Application
    Filed: August 19, 2010
    Publication date: January 19, 2012
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Shai Rubnov