Patents by Inventor Eifion Phillips
Eifion Phillips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7982038Abstract: A radioactive compound having the formula: and pharmaceutically-acceptable salts thereof, wherein R1 and Ar are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.Type: GrantFiled: September 24, 2004Date of Patent: July 19, 2011Assignee: AstraZeneca ABInventors: Peter Dorff, John Gordon, John Richard Heys, Richard A Keith, Dennis J McCarthy, Mark A Smith, Eifion Phillips
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Publication number: 20110136804Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: ApplicationFiled: November 5, 2010Publication date: June 9, 2011Applicant: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Publication number: 20110124672Abstract: Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and the use of such compounds and compositions for use in therapy.Type: ApplicationFiled: October 27, 2010Publication date: May 26, 2011Applicant: AstraZeneca ABInventors: Hui-Fang Chang, Yan Li, Eifion Phillips
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Patent number: 7842803Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: GrantFiled: May 17, 2007Date of Patent: November 30, 2010Assignee: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Publication number: 20100034741Abstract: The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the ?7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express ?7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.Type: ApplicationFiled: January 26, 2009Publication date: February 11, 2010Applicants: The Johns Hopkins UniversityInventors: Martin G. Pomper, John L. Musachio, Hong Fan, Robert F. Dannals, Catherine Foss, Eifion Phillips, John Gordon, Dennis McCarthy, Richard Keith, Mark Smith, Richard Heys, Peter N. Dorff
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Patent number: 7544693Abstract: Compounds of formula I: wherein Ar is a moiety of formula II or III: and pharmaceutically-acceptable salts thereof, wherein A, B, and R1 are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.Type: GrantFiled: October 21, 2004Date of Patent: June 9, 2009Assignee: AstraZeneca ABInventor: Eifion Phillips
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Patent number: 7514567Abstract: Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Q, Ar1, A and Ar2 are as defined in the specification, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them, uses of them as medicaments for therapy, uses of them in the manufacture of medicaments and uses of them for diagnostic and analytic purposes.Type: GrantFiled: July 6, 2004Date of Patent: April 7, 2009Assignee: AstraZeneca ABInventors: Hui-Fang Chang, Eifion Phillips
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Patent number: 7507744Abstract: A pharmaceutical composition comprising a compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, or pharmaceutically acceptable salts thereof, its use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.Type: GrantFiled: March 15, 2004Date of Patent: March 24, 2009Assignee: AstraZeneca ABInventors: Eifion Phillips, Robert Mack, John Macor, Simon Semus
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Patent number: 7491734Abstract: Compounds of formula I: wherein A, D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.Type: GrantFiled: March 1, 2007Date of Patent: February 17, 2009Assignee: AstraZeneca ABInventors: Eifion Phillips, Richard Schmiesing
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Patent number: 7482338Abstract: Compounds of Formula I: and pharmaceutically-acceptable salts thereof, wherein Q, E and D are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.Type: GrantFiled: September 24, 2004Date of Patent: January 27, 2009Assignee: AstraZeneca ABInventors: Glen Ernst, Eifion Phillips, Richard J Schmiesing
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Patent number: 7417050Abstract: Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and the use of such compounds and compositions for use in therapy.Type: GrantFiled: April 15, 2003Date of Patent: August 26, 2008Assignee: AstraZeneca ABInventors: Hui-Fang Chang, Eifion Phillips
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Patent number: 7417049Abstract: Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and methods of using such compounds and compositions in therapy.Type: GrantFiled: April 15, 2003Date of Patent: August 26, 2008Assignee: AstraZeneca ABInventors: Hui-Fang Chang, Yan Li, Eifion Phillips
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Publication number: 20080188518Abstract: Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.Type: ApplicationFiled: November 15, 2004Publication date: August 7, 2008Applicant: ASTRA ZENECA ABInventors: James Empfield, Eifion Phillips, Scott Throner
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Publication number: 20080153864Abstract: A compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, pharmaceutical compositions containing said compound, pharmaceutically acceptable salts thereof, its use in therapy, especially in the treatment of psychotic disorders and intellectual impairment disorders.Type: ApplicationFiled: March 13, 2008Publication date: June 26, 2008Inventors: Eifion Phillips, Robert Mack, John Macor, Simon Semus
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Publication number: 20080139600Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: ApplicationFiled: May 17, 2007Publication date: June 12, 2008Applicant: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Patent number: 7384954Abstract: Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.Type: GrantFiled: November 15, 2004Date of Patent: June 10, 2008Assignee: AstraZeneca ABInventors: James R. Empfield, Eifion Phillips, Scott Throner
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Publication number: 20080113983Abstract: Acetylcholine receptor ligands of formula I wherein A, Ar1 and Ar2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: December 13, 2005Publication date: May 15, 2008Applicant: AstraZeneca ABInventors: Marc Chapdelaine, Hui-Fang Chang, Keith J. Herzog, Carey Horchler, Eifion Phillips
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Publication number: 20070270458Abstract: Compounds of formula I: wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.Type: ApplicationFiled: December 20, 2004Publication date: November 22, 2007Inventors: Glen Ernst, Robert Jacobs, Eifion Phillips
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Publication number: 20070249588Abstract: Acetylcholine receptor ligands of formula (I), wherein D, Ar1, E and Ar2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: December 20, 2004Publication date: October 25, 2007Applicant: AstraZeneca ABInventors: Glen Ernst, William Frietze, Robert Jacobs, Eifion Phillips
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Publication number: 20070244097Abstract: Acetylcholine receptor ligands of formula I wherein D, E and G are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: December 20, 2004Publication date: October 18, 2007Applicant: AstraZeneca ABInventors: Glen Ernst, William Frietze, Robert Jacobs, Eifion Phillips