Patents by Inventor Eiichi Mano

Eiichi Mano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidation process using tempo
    Patent number: 6031101
    Abstract: The present invention relates to an oxidation using sodium chlorite in the presence of a catalytic amount of TEMPO and sodium hypochlorite which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula I having a carboxylic acid ##STR1##
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: February 29, 2000
    Assignees: Merck & Co., Inc., Banyu Pharmaceuticals Co., Ltd
    Inventors: Paul N. Devine, Eiichi Mano, Zhiguo Song, David M. Tschaen, Mangzu Zhao
  • Crystalline cephalosporin compounds
    Patent number: 5068322
    Abstract: The present invention relates to stable crystalline (6R,7R)-7-(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxylimino)ac etamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carbox ylate sulfate or its hydrate, a process for production of the compound and (6R,7R)-7-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino) acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carb oxylate hydrochloride or its hydrate which is a starting material useful for the production of the desired compound of the present invention.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: November 26, 1991
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Susumu Nakagawa, Ryosuke Ushijima, Fumio Nakano, Koji Yamada, Eiichi Mano
  • Isoindoline derivatives and processes for their preparation
    Patent number: 4987235
    Abstract: A compound having the formula: ##STR1## wherein R is a hydrogen atom, a lower alkyl group, an alkanoyl group, an aralkyl group, an alkylsulfonyl group or an arylsulfonyl group, and R.sup.1 is a hydrogen atom or a protecting group for a hydroxyl group, or a salt thereof.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: January 22, 1991
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Ryosuke Ushijima, Susumu Nakagawa, Eiichi Mano
  • Crystalline cephalosporin compounds
    Patent number: 4959469
    Abstract: The present invention relates to stable cyrstalline (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)ac etamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)-3-cephem-4-carboxylate sulfate or its hydrate, a process for production of the compound and (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxyl-1-methylethoxyimino)a cetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carbo xylate hydrochloride or its hydrate which is a starting material useful for the production of the desired compound of the present invention.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: September 25, 1990
    Assignee: Banyu Pharmaceutical Company, Ltd.
    Inventors: Susumu Nakagawa, Ryosuke Ushijima, Fumio Nakano, Koji Yamada, Eiichi Mano
  • 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
    Patent number: 4883868
    Abstract: A compound having the formula: ##STR1## wherein R.sup.1 is an amino group or a protected amino group, R.sup.2 is a hydrogen atom or a protecting group for a hydroxyl group, R.sup.3 represents negative charge, a hydrogen atom or a protecting group for a carboxyl group, and n is 0 or 1, and a salt thereof.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: November 28, 1989
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Susumu Nakagawa, Ryosuke Ushijima, Fumio Nakano, Koji Yamada, Eiichi Mano
  • 3-Isoquinoliniomethyl cephalosporin derivatives
    Patent number: 4742053
    Abstract: The invention relates to an antibiotic comprising a compound having the formula: ##STR1## wherein R.sup.1 is a straight chain, branched chain, or cyclic lower alkyl group which may be substituted by a carboxyl group, and R.sup.2 designates vicinal dihydroxyl groups or diacetoxy groups; or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: May 3, 1988
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Susumu Nakagawa, Ryosuke Ushijima, Eiichi Mano, Norikazu Ban, Minoru Sanada
  • Cephalosporin derivatives
    Patent number: 4677100
    Abstract: A compound having the formula: ##STR1## wherein R.sup.1 is a straight chain, branched chain or cyclic lower alkyl group which may be substituted by a carboxyl group, and each of R.sup.2 and R.sup.3 which may be the same or different, is a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group, and R.sup.4 is a hydroxyl group, a methoxy group or an acetoxy group; or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
    Type: Grant
    Filed: December 26, 1985
    Date of Patent: June 30, 1987
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Susumu Nakagawa, Ryosuke Ushijima, Fumio Nakano, Koji Yamada, Eiichi Mano