Abstract: The check valve includes: an inlet pipe body part (23) which includes an inflow port (23b); an outlet pipe body part (25) which includes an outflow port (25b); a mobile body (a reciprocative body (2)). Insides of the inlet pipe body part, the outlet pipe body part, and the valve body (12) are communicated to form a curved flow path from the inflow port toward the outflow port. The reciprocative body includes a valve element (6). The seat (23c) is arranged so as to be capable of supporting the valve element and the inflow port and the seat are arranged parallel to each other. An inner wall surface (23y) on an outside-corner side of the flow path in the inlet pipe body part is formed so as to curve toward a side of the outlet pipe body part as a position gets closer from the inflow port to the seat.

Abstract: The check valve (1) is of straight pipe joint type and oblique lift type. It includes: a valve seat (12a); a moving body (2) capable of linearly reciprocating between a closed state where it is in close contact with the valve seat and an open state where it is separated from the valve seat; a primary flow path (inflow path (12c)) on an upstream side of the moving body; and a secondary flow path (outflow path (12d)) on a downstream side of the moving body. The moving body includes a valve body (6) and a valve shaft (7) extending from the valve body. The valve seat supporting the valve body is formed to straddle the center line (CL) of the connection flow path that linearly extends including the primary flow path (inflow path) and the secondary flow path (outflow path 12d) in a cross section including the center line thereon.

Abstract: The check valve (1) is of straight pipe joint type and oblique lift type. It includes: a valve seat (12a); a moving body (2) capable of linearly reciprocating between a closed state where it is in close contact with the valve seat and an open state where it is separated from the valve seat; a primary flow path (inflow path (12c)) on an upstream side of the moving body; and a secondary flow path (outflow path (12d)) on a downstream side of the moving body. The moving body includes a valve body (6) and a valve shaft (7) extending from the valve body. The valve seat supporting the valve body is formed to straddle the center line (CL) of the connection flow path that linearly extends including the primary flow path (inflow path) and the secondary flow path (outflow path 12d) in a cross section including the center line thereon.

Abstract: The present invention provides a method for screening for a food ingredient or a food composition that reduces a cancer risk and inhibits cancer development. A substance that reduces a cancer risk is screened by administering a candidate substance and analyzing alteration in gut microbiota or a metabolite produced by an intestinal bacterium. Also, candidate substances are screened by adding each candidate substance to a bacterial culture system and analyzing its effect on a bacterium involved in cancer development.

Abstract: The present invention provides a method capable of detecting a cancer and/or a carcinogenic risk, and a reagent for the detection thereof. The present invention also provides a method for screening for a pharmaceutical drug for reducing a carcinogenic risk and a pharmaceutical composition. Since cancer development closely correlates with alteration in gut microbiota, cancer development and/or a risk of cancer development are detected by detecting alteration in gut microbiota and a secondary bile acid produced by an intestinal bacterium. The present invention further provides a method for screening for a pharmaceutical drug with a gut microbiota as an index, and a pharmaceutical composition.

Abstract: The present invention provides a method for screening for a food ingredient or a food composition that reduces a cancer risk and inhibits cancer development. A substance that reduces a cancer risk is screened by administering a candidate substance and analyzing alteration in gut microbiota or a metabolite produced by an intestinal bacterium. Also, candidate substances are screened by adding each candidate substance to a bacterial culture system and analyzing its effect on a bacterium involved in cancer development.

Abstract: The present invention provides a method capable of detecting a cancer and/or a carcinogenic risk, and a reagent for the detection thereof. The present invention also provides a method for screening for a pharmaceutical drug for reducing a carcinogenic risk and a pharmaceutical composition. Since cancer development closely correlates with alteration in gut microbiota, cancer development and/or a risk of cancer development are detected by detecting alteration in gut microbiota and a secondary bile acid produced by an intestinal bacterium. The present invention further provides a method for screening for a pharmaceutical drug with a gut microbiota as an index, and a pharmaceutical composition.

Abstract: A method for analyzing a minute quantity of a material included in a different material is performed in short extraction treatment without taking a long time and the minute content is rapidly analyzed. The method of analyzing a minute content includes mounting on a sample table a sample piece of a material having a minute content of a different material to be analyzed; dropping onto the sample table a solvent for extracting the minute content from the sample piece, so that the solvent is disposed between the sample table and the sample piece; maintaining at room temperature the solvent between the sample table and the sample piece, and, with the solvent maintained between the sample table and the sample piece, extracting the material of the minute content from the sample piece; and analyzing the content extracted from the sample piece.

Abstract: A beverage dispenser has gauges to measure the temperature of the beverage, in at least one embodiment beer, stored in a closed beverage container. The beverage is pressurized and a pressure gauge in the gas supply conduit line measures the pressure of the gas in the beverage container. A pressure regulator in the gas supply conduit line assists in ensuring that the pressure is consistent. The valve is closed during dispensation and the temperature and the gas pressure are measured immediately afterwards. By calculating the temperature change of the beverage and the pressure drop in the container, the amount of beverage can be calculated accurately. This in turn can be utilized to reliably calculate how beverage is left in the container and this information is then presented on a display, in at least one embodiment, as a series of indicator bars.

Abstract: The anthranilic acid derivative or the salt thereof represented by the general formula wherein R1 and R2 are hydrogen atom, or the like; R3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X1 is an alkylene or alkenylene group which may be substituted or a bond; X2 is the general formula —X3—X4— or —X4—X3—, wherein X3 is a sulfur atom, an imino group or a bond, or the like; X4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP—13 production inhibitory effect.

Abstract: An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene group, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula —X5—X6— or —X6—X5— (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

Abstract: A sample preparation for analyzing a minute quantity of a content included in a material is performed by short-time extraction treatment without long-time extraction treatment, and the minute quantity of the content in the material is rapidly analyzed. The method of analyzing a minute quantity of a content includes mounting on a sample table a sample piece of a material to be analyzed; dropping onto the sample table the solvent for extracting the content from the sample piece, and injecting the solvent into a gap between the sample table and the sample piece; maintaining at room temperature the solvent injected into the gap between the sample table and the sample piece, and, with the solvent maintained in the gap between the sample table and the sample piece, extracting the content from the sample piece; and analyzing the content extracted from the sample piece.

Abstract: An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene group, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula -X5-X6- or -X6-X5- (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

Abstract: A beverage dispenser includes beverage temperature measurement means for measuring a temperature of beverage stored in a closed beverage container; pressure measurement means disposed in a gas supply conduit supplying gas into the beverage container from a source of pressurized gas for measuring a gas pressure in the beverage container; a pressure regulator valve disposed in the gas supply conduit for regulating a pressure of gas supplied to the beverage container; discharge means for discharging an amount of beverage supplied thereto from a beverage supply conduit connected to the beverage container; wherein the pressure regulator valve is opened and closed in such a manner that the gas pressure in the container becomes a proper pressure calculated in accordance with a temperature of the beverage measured by the temperature measurement means, wherein the beverage dispenser further comprises gas flow measurement means disposed in the gas supply conduit at a downstream of the pressure regulator valve for measu

Abstract: The anthranilic acid derivative or the salt thereof represented by the general formula wherein R1 and R2 are hydrogen atom, or the like; R3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X1 is an alkylene or alkenylene group which may be substituted or a bond; X2 is the general formula -X3-X4- or -X4-X3-, wherein X3 is a sulfur atom, an imino group or a bond, or the like; X4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.

Abstract: The present invention provides a closed type battery that is free from any sealing defects due to a sag of caulking with time, etc. The closed type battery is constructed of a monolithic electrode terminal that comprises an insulating member for covering the inner surface of a through-hole formed through a metal sheet for sealing up an opening of a battery can and both surfaces of the metal sheet around the through-hole, and an electrode-drawing sheet having a synthetic resin layer formed on one surface thereof, which sheet is located on the surface of the insulating member positioned on the outer surface of the battery while the synthetic resin layer comes in contact therewith, wherein the electrode-drawing sheet and the insulating member are integrated together by means of an electrode-leading pin passed through a through-hole in the electrode-drawing sheet.

Abstract: A first operation of a lever causes a valve rod to retract axially through a second valve element seated on a second valve seat against a first resilient part, while a first valve element to leave a first valve seat open to pour beer from a beer pouring nozzle through a beer supply channel. A second operation of the lever causes a slider to advance axially against a second resilient part to be spaced away from the valve rod forcing the first valve element to be seated on the first valve seat, while the second valve element to leave the second valve seat open to effect frothing of the beer from a liquid passage and pour the resulting froth through holes defined in a sleeve.

Abstract: The present invention provides a closed type battery that is free from any sealing defects due to a sag of caulking with time, etc. The closed type battery is constructed of a monolithic electrode terminal that comprises an insulating member for covering the inner surface of a through-hole formed through a metal sheet for sealing up an opening of a battery can and both surfaces of the metal sheet around the through-hole, and an electrode-drawing sheet having a synthetic resin layer formed on one surface thereof, which sheet is located on the surface of the insulating member positioned on the outer surface of the battery while the synthetic resin layer comes in contact therewith, wherein the electrode-drawing sheet and the insulating member are integrated together by means of an electrode-leading pin passed through a through-hole in the electrode-drawing sheet.

Abstract: A first operation of a lever causes a valve rod to retract axially through a second valve element seated on a second valve seat against a first resilient part, while a first valve element to leave a first valve seat open to pour beer from a beer pouring nozzle through a beer supply channel. A second operation of the lever causes a slider to advance axially against a second resilient part to be spaced away from the valve rod forcing the first valve element to be seated on the first valve seat, while the second valve element to leave the second valve seat open to effect frothing of the beer from a liquid passage and pour the resulting froth through holes defined in a sleeve.

Abstract: Disclosed herein are Human Id genes (Id-1H and Id-1H') and variants thereof. Origin, preparation process, biochemical functions and the like: two synthetic oligonucleotides separately having base sequences corresponding to regions of amino acid sequence, which are almost completely conserved by three mouse Id genes (Id-1, Id-2 and HLH462) are used as probes to screen clones having respective cDNAs complementary to the probes from a cDNA library of human TIG-1 fibroblasts in accordance with the hybridization method, thereby isolating human Id genes. The expression of the human Id genes specifically varies according to the state of cell proliferation, in particular, the acquisition of cell aging and permanently proliferating ability.