Patents by Inventor Eiji Higashide

Eiji Higashide has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4623733
    Abstract: Novel peptide B-52653 having the formula: ##STR1## which is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing B-52653 in a culture medium, whereby B-52653 is elaborated and accumulated in the cultured broth and is recovered.B-52653 is useful as a germicide or disinfectant, and a possibility of the present substance as an antifibrotic agent is suggested.
    Type: Grant
    Filed: July 10, 1984
    Date of Patent: November 18, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Satoshi Horii
  • Patent number: 4575489
    Abstract: Novel peptide B-52653 having the formula: ##STR1## which is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing B-52653 in a culture medium, whereby B-52653 is elaborated and accumulated in the cultured broth and is recovered.B-52653 is useful as a germicide or disinfectant, and a possibility of the present substance as an antifibrotic agent is suggested.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: March 11, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Satoshi Horii
  • Patent number: 4465844
    Abstract: The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.
    Type: Grant
    Filed: August 23, 1983
    Date of Patent: August 14, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Satoshi Horii, Hiroshi Fukase, Eiji Higashide
  • Patent number: 4436918
    Abstract: The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: March 13, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Satoshi Horii, Hiroshi Fukase, Eiji Higashide
  • Patent number: 4373028
    Abstract: A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 is a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium and recovering the same antibiotic.Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.
    Type: Grant
    Filed: July 14, 1981
    Date of Patent: February 8, 1983
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Seiichi Tanida, Masayuki Muroi, Mitsuko Asai
  • Patent number: 4360462
    Abstract: A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.
    Type: Grant
    Filed: October 22, 1981
    Date of Patent: November 23, 1982
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Seiichi Tanida
  • Patent number: 4320200
    Abstract: A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.
    Type: Grant
    Filed: March 19, 1980
    Date of Patent: March 16, 1982
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Seiichi Tanida
  • Patent number: 4315989
    Abstract: The present invention relates to a substantially pure culture of the microorganism belonging to the genus Nocardia, which microorganism is capable of producing in a culture medium containing assimilable carbon and digestible nitrogen sources, a recoverable amount of the Antibiotic C-14919 E-1 or E-2 or mixtures thereof having the characteristics described in the specification. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.
    Type: Grant
    Filed: August 11, 1980
    Date of Patent: February 16, 1982
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Toru Hasegawa
  • Patent number: 4298600
    Abstract: A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 in a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium, and recovering the same antibiotic.Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.
    Type: Grant
    Filed: August 2, 1978
    Date of Patent: November 3, 1981
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Seiichi Tanida, Masayuki Muroi, Mitsuko Asai
  • Patent number: 4292309
    Abstract: Novel antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 in a culture medium, whereby Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 are elaborated and accumulated in the cultured broth and are recovered.Antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are useful as a germicide or disinfectant, respectively.
    Type: Grant
    Filed: January 17, 1980
    Date of Patent: September 29, 1981
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Seiichi Tanida, Masayuki Muroi, Mitsuko Asai
  • Patent number: 4245047
    Abstract: The present invention relates to a method of producing the antibiotics C-14919 E-1 and/or E-2 by cultivating an antibiotic C-14919 E-1 and/or E-2 producing strain of the genus Nocardia in a culture medium and accumulating said antibiotics. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: January 13, 1981
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Toru Hasegawa
  • Patent number: 4229533
    Abstract: A novel Antibiotic C-15003 P-4 is specifically produced by cultivating a microorganism of the genus Nocardia in a culture medium containing leucine and/or its derivatives.The Antibiotic C-15003 P-4 is useful as an antifungal agent, antiprotozoan agent and antitumor agent.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: October 21, 1980
    Assignee: Takeca Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Kazunori Hatano, Mitsuko Asai
  • Patent number: 4228239
    Abstract: A novel Antibiotic C-15003 P-3 is specifically produced by cultivating a microorganism of the genus Nocardia in a culture medium containing valine or isobutyric acid and/or their derivatives.The Antibiotic C-15003 P-3 is useful as an antifungal, antiprotozoan and antitumor agent.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: October 14, 1980
    Assignee: Takeda Chemical Industries, Ltd
    Inventors: Eiji Higashide, Kazunori Hatano, Mitsuko Asai
  • Patent number: 4225494
    Abstract: A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: September 30, 1980
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Seiichi Tanida
  • Patent number: 4187292
    Abstract: The present invention relates to antibiotics C-14919 E-1 and E-2 produced by cultivating a microorganism of the genus Nocardia. These antibiotics display a wide activity against e.g. Gram-positive bacteria, fungi and yeast and are useful as germicides or disinfectants.
    Type: Grant
    Filed: July 12, 1977
    Date of Patent: February 5, 1980
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Toru Hasegawa
  • Patent number: 4162940
    Abstract: A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: July 31, 1979
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Seiichi Tanida
  • Patent number: 4151042
    Abstract: Maytansinol, maytanacine or maytansinol propionate is (are) produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing maytansinol, maytanacine or maytansinol propionate, causing the microorganism to accumulate maytansinol, maytanacine or maytansinol propionate and recovering the same.Those compounds are useful for anti-tumor agents.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: April 24, 1979
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Mitsuko Asai, Seiichi Tanida