Patents by Inventor Eileen J. Kennedy

Eileen J. Kennedy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Disruption of the WAVE3 protein complex for suppression of invasion and metastasis
    Patent number: 11773146
    Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: October 3, 2023
    Assignees: University of Georgia Research Foundation, Inc., Augusta University Research Institute
    Inventors: Eileen J. Kennedy, John Cowell
  • CHEMICALLY-STABILIZED ALLOSTERIC MODULATORS OF LEUCINERICH REPEAT KINASE 2 (LRRK2)
    Publication number: 20230220019
    Abstract: The present disclosure describes synthetic polypeptides for the inhibition or modulation of the activity of leucine-rich repeat kinase 2 (LRRK2) along with methods of using the same in the treatment of medical conditions, for example neurological diseases or disorders.
    Type: Application
    Filed: February 25, 2021
    Publication date: July 13, 2023
    Inventors: Eileen J. Kennedy, Arjan Kortholt, Leah G. Helton
  • DISRUPTION OF THE WAVE3 PROTEIN COMPLEX FOR SUPPRESSION OF INVASION AND METASTASIS
    Publication number: 20210024595
    Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 28, 2021
    Inventors: Eileen J. Kennedy, John Cowell
  • Disruption of the WAVE3 protein complex for suppression of invasion and metastasis
    Patent number: 10822380
    Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: November 3, 2020
    Assignees: University of Georgia Research Foundation, Inc., Augusta University Research Institute, Inc.
    Inventors: Eileen J. Kennedy, John Cowell
  • DISRUPTION OF THE WAVE3 PROTEIN COMPLEX FOR SUPPRESSION OF INVASION AND METASTASIS
    Publication number: 20180072782
    Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 15, 2018
    Inventors: Eileen J. Kennedy, John Cowell