Abstract: The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.

Abstract: The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.

Abstract: The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.

Abstract: The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.

Abstract: This invention provides pharmaceutical preparations containing highly concentrated tumor cytotoxic factor (TCF). The pharmaceutical preparations of the present invention contain highly concentrated TCF and a basic amino acid or their salts, or an organic or inorganic salt as a solubizer. The resultant compositions described in the present invention dissolve TCF at high concentrations of 10 mg/ml or over under about neutral and isotonic conditions. The resultant compositions are stable and are suitable for injection preparations.

Abstract: A process and system for cultivating adhesive cells in a packed bed of solid cell matrix is disclosed. Adhesive cells are adhered to a solid cell matrix, preferably ceramic particles, and packed in a cell culture tank to form the packed bed. The culture medium is circulated through the packed bed in a direction. The circulating of the culture medium is then stopped and the direction of the medium being circulated is reversed. This periodic switching of the direction of the culture medium reduces channelling of the culture medium. The bottom or head of the culture tank can also contain a separator to trap any bubble existing in the culture medium or to trap any quantity of cell matrix possibly running out from the culture tank.

Abstract: Cell cultivation is carried out by proliferating cells in a small preliminary culture tank containing immobilizing carriers, stripping proliferated cells from the carriers, forming a cell suspension of the stripped cells in culture medium in an intermediate reservoir, intermittently transferring the suspension into a main culture tank containing ceramic immobilizing carriers and further culturing the cells. The main culture tank has an inversed funnel-shaped inlet above the carriers with a perforated plate attached to the bottom of the inlet for uniform distribution of cell suspension from above the carriers, and a plate in the form of a net under the carriers on a perforated plate for uniform distribution of cell suspension from beneath the carriers.

Abstract: There is provided between a concentrate tank and a membrane filter a circulating line which consists of a feed line and a return line. It is also possible to use an ultrafilter as the membrane filter. There is provided a leveling tube connected by respective pipes to the concentrate tank at top and bottom portions thereof, respectively. A buoy floats within the leveling tube and a position of this buoy is detected by means of transparency of the leveling tube itself or photosensors in order to detect a degree of concentration of the culture fluid progressing within the concentrate tank. There may be provided multi-stage circulating lines each connecting the associated concentrate tank to the associated membrane filter so that the culture fluid can be transferred during the process of concentration from the stage of the largest volume treatment to the state of the least volume treatment in order to concentrate the culture fluid more efficiently.

Abstract: Here is disclosed a cell culture tank comprising a cylindrical screen mounted upright within the cell culture tank and having upper and lower openings through which culture medium flows, a pipe for supply of oxygen or oxygen containing gas and an agitator adapted to produce a flow of the culture medium, both the pipe and the agitator being provided within the cylindrical screen, wherein the agitator drives the culture medium to flow downward through the lower opening of the cylindrical screen, then to flow upward into a space defined between the cylindrical screen and the inner wall of the cell culture tank, and a relationship between an ascending velocity of the culture medium and a sinking velocity of the adherent carriers produces in the space between the cylindrical screen and the inner wall of the cell culture tank a floating region within which the adherent carriers float in the culture medium and a separating region within which the adherent carriers are separated from the culture medium.

Abstract: An apparatus is disclosed wherein a highly viscous, heat-sensitive material such as concentrated whole milk or concentrated fruit juice is supplied onto a plural-stage belt conveyor stretched within a vacuum chamber and is dried and solidified by means of a heating member while moving along the belt conveyor. The resulting dried material is received by a fixed cutter provided within a casing disposed at the turning point where the belt conveyor is to turn to the return stroke side. This dried material is then crushed by a crushing device equipped with said fixed cutter and a rotary cutter cooperating therewith, and the thus crushed material is let fall within the casing and discharged to the outside of the vacuum chamber by means of a discharging device equipped with a screw wing installed in the lower part of the casing.

Abstract: An improved apparatus for supplying materials, useful for belt type continuous vacuum dryer, is provided which comprises an inner cylinder equipped with a material-supplying duct fixed onto one end thereof, a distributing chamber formed inside the cylinder and communicating with the duct and a plurality of distributing nozzles fixed thereto; an outer cylinder having the inner cylinder rotatably inserted thereinto and having a plurality of distributing nozzles provided at the opposed locations to the former distributing nozzles; a screw feeder provided in freely rotatable manner inside the distributing chamber; and a driving mechanism for rotating the outer cylinder.According to this apparatus, it is possible to supply materials on a moving belt, continuously and uniformly over the whole surface of the belt.

Abstract: A material feed pipe for use in a belt-system continuous vacuum drier and oriented above a belt moving within a vacuum drying chamber. The feed pipe includes an inner tube having its one end provided with an inlet for material and the other end being closed. An outer tube has its two ends closed and encircling said inner tube with a radial space therebetween. A plurality of nozzle openings are provided in an upper part of the inner tube at a fixed pitch along the axial length thereof. The nozzle openings are so devised as to have a larger diameter in regular succession from the inlet end to the opposite end of the inner tube; and a plurality of further nozzle openings are provided in the lower part of the outer tube at a fixed pitch along the axial length thereof and have a fixed diameter.

Abstract: A fish meat powder retaining the functional characteristics of fresh fish meat is obtained by mincing and kneading fresh meat or frozen SURIMI (frozen ground fish meat), then subjecting the minced and kneaded meat to a colloid mill treatment to form a sol, foaming the resultant fish meat sol in a vacuum and drying the fish meat foam to form a thin sheet at low temperatures.

Abstract: Vacuum type powder producing apparatus comprising an endless belt passing around a pair of vertically spaced rollers to provide a downward and upward runs, a vacuum chamber encircling only the downward run of the belt. Slurry of material is applied to the belt surfaces at the inlet end of the vacuum chamber and dried in the chamber under vacuum. Suitable belt cleaning device is provided outside the vacuum chamber.