Patents by Inventor Ekkehard Niemers
Ekkehard Niemers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4636497Abstract: The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.Type: GrantFiled: August 29, 1985Date of Patent: January 13, 1987Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Rudi Grutzmann, Mithat Mardin, Wolf-Dieter Busse, Horst Meyer
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Patent number: 4567188Abstract: Compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted aryl or heteroaryl radical,R.sup.2 is an alkyl or alkenyl radical which is optionally substituted by alkoxy or cycloalkyl, or an optionally substituted aryl or heteroaryl radical, and X is an optionally aklyl-substituted methylene radical or a direct bond, but if X is a direct bond R.sup.2 is not aryl,or physiologically acceptable acid addition salts thereof, exhibit activity on the circulation system particularly as hypotensive agents.Type: GrantFiled: August 10, 1983Date of Patent: January 28, 1986Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Andreas Knorr, Bernward Garthoff
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Patent number: 4491595Abstract: Trisubstituted cyanoguanidines of the formula ##STR1## in which R.sup.1 represents an optionally substituted phenyl or phenylalkyl radical, an alkyl radical with more than 1 carbon atom, a substituted alkyl radical, an alkenyl or alkinyl radical or an optionally substituted cycloalkyl radical,R.sup.2 represents an optionally substituted alkyl radical or an alkenyl or alkinyl radical andR.sup.3 represents an optionally substituted alkyl radical, an alkenyl or alkinyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl or phenylalkyl radical, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical, which optionally contains an oxygen atom as a further hetero-atom,or a physiologically acceptable acid addition salt thereof, which possess fungicidal properties. Processes for their preparation are also taught.Type: GrantFiled: March 30, 1981Date of Patent: January 1, 1985Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Winfried Lunkenheimer, Wilhelm Brandes
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Patent number: 4344939Abstract: New penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R.sub.1 denotes a hydrogen atom or an ester-forming radical,R.sub.2 denotes a hydrogen atom,R.sub.3 denotes a hydrogen atom,R.sub.4 denotes a hydrogen atom, an optionally substituted naphthyl radical or a radical of the general formula ##STR2## and the remaining variables can be various organic radicals.Type: GrantFiled: May 29, 1980Date of Patent: August 17, 1982Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Hans-Bodo Konig, Wilfried Schrock, Karl G. Metzger
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Patent number: 4344955Abstract: Anti-bacterially active penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R.sub.1 denotes a hydrogen atom or an ester-forming radical,R.sub.2 denotes a hydrogen atom or optionally substituted alkoxy group,R.sub.3 denotes a hydrogen atom, COR.sub.4, SO.sub.2 -alkyl, SO.sub.2 -aryl or an optionally substituted alkyl group, but R.sub.2 and R.sub.3 do not simultaneously denote hydrogen atoms, andR.sub.4 denotes a hydrogen atom or any of many possible organic radicals.The compounds are also inhibitors of .beta.-lactamases so they can be used in conjunction with .beta.-lactamase-susceptible antibiotics. They are useful in fighting bacterial infection, in promoting animal growth and in preserving various materials.Type: GrantFiled: June 12, 1980Date of Patent: August 17, 1982Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Hans-Bodo Konig, Wilfried Schrock, Karl G. Metzger
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Patent number: 4246260Abstract: The invention relates to new substituted o-phenylenediamine derivatives of the general formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkinyl,X represents O, S, SO or SO.sub.2 andR.sup.1 and R.sup.2 are different from one another and individually represent ##STR2## in which R.sup.3 and R.sup.4 are identical or different and represent alkyl andR.sup.5 represents hydrogen, optionally substituted alkyl or optionally substituted alkoxy, and salts thereof.Also included in the invention are (1) methods for preparing the above-described compounds, (2) compositions containing the above-described compounds and (3) methods for the treatment of helminthiasis.Type: GrantFiled: March 19, 1979Date of Patent: January 20, 1981Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Ekkehard Niemers, Hartmund Wollweber, Herbert Thomas
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Patent number: 4194004Abstract: Novel substituted benzenesulphonic acid esters, particularly useful as anthelmintics are provided. The novel compounds are those of the general formula ##STR1## in which R represents hydrogen, optionally substituted alkyl, cyano, alkoxy, halogen, trifluoromethyl, amino, acylamino or nitro,X represents SO.sub.3 andR.sup.1 and R.sup.2 are different from one another and individually represent one of the radicals ##STR2## wherein Y represents S andR.sub.3 represents hydrogen, optionally substituted alkyl or alkoxy,and salts thereof. Also included in the invention are methods for preparing the novel compounds, compositions containing them and methods for the use of the compounds and compositions.Type: GrantFiled: November 2, 1977Date of Patent: March 18, 1980Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Hartmund Wollweber, Heinrich Kolling, Herbert Thomas
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Patent number: 4064270Abstract: A new class of N'-(aminoacylaminophenyl) acetamidines: ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, alkyl, aryl or the substituted derivatives thereof or, together with the nitrogen atom to which they are attached, an heterocyclic ring; and R.sup.3 is hydrogen, alkyl, aryl, aralkyl, or a heterocyclic moiety including the substituted derivatives thereof. The products have utility as anthelmintics.The products are obtained by treating a suitable amino-acid or a carbonyl-activated amino-acid, with the appropriate N'-(4-aminophenyl)-N,N-dimethylacetamidine. In addition, the products are obtained by treating a suitable N'-(haloacylaminophenylacetamidine with an appropriate amine.Type: GrantFiled: September 13, 1974Date of Patent: December 20, 1977Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Ekkehard Niemers, Hans Peter Schulz, Herbert Thomas, Peter Andrews
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Patent number: 4015012Abstract: New 4-acylaminophenylacetamidines of the formula: ##STR1## in which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.Type: GrantFiled: May 21, 1975Date of Patent: March 29, 1977Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Ekkehard Niemers, Hans Peter Schulz, Herbert Thomas, Peter Andrews
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Patent number: 3970699Abstract: New 4-acylaminophenylacetamidines of the formula: ##SPC1##In which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.Type: GrantFiled: September 13, 1974Date of Patent: July 20, 1976Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Ekkehard Niemers, Hans Peter Schulz, Herbert Thomas, Peter Andrews