Patents by Inventor Elazer R. Edelman
Elazer R. Edelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240138684Abstract: A method for determining material properties of a plurality of tissues in a subject includes receiving a first sequence of cardiovascular images of a region of interest of the subject and a first set of pressure data associated with the first sequence of cardiovascular images and receiving a second sequence of cardiovascular images of the region of interest of the subject and a second set of pressure data associated with the second sequence of cardiovascular images. The method can further include transforming, using a processor, the first sequence of cardiovascular images to a first three-dimensional (3D) finite element (FE) mesh with heterogeneous material distribution, transforming, using the processor, the second sequence of cardiovascular images to a second 3D FE mesh with heterogeneous material distribution, and performing, using the processor, an iterative optimization process on the first and second 3D FE meshes to determine one or more material properties of at least one of the plurality of tissues.Type: ApplicationFiled: February 15, 2022Publication date: May 2, 2024Inventors: Bharath NARAYANAN, Max Louis OLENDER, Farhad Rikhtegar NEZAMI, David MARLEVI, Elazer R. EDELMAN
-
Publication number: 20230241250Abstract: Provided herein are, in various embodiments, methods and compositions of inducing M2-like macrophage morphology. In certain embodiments, a composition comprising a polynucleotide encoding a ring finger protein 41 (RNF41) is contemplated. The disclosure also provides a method of preventing, treating, managing, and/or ameliorating tissue damage in a subject in need thereof. In some embodiments, the subject has chronic liver disease, chronic liver inflammation, chronic hepatic fibrosis, cirrhosis, or a combination thereof. In still further embodiments, the subject has undergone liver resection or liver transplantation.Type: ApplicationFiled: February 1, 2023Publication date: August 3, 2023Inventors: Elazer R. Edelman, Pedro Melgar Lesmes
-
Publication number: 20230238146Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).Type: ApplicationFiled: December 23, 2022Publication date: July 27, 2023Applicants: ABIOMED, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Qing Tan, Ahmad El Katerji, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller, Sonya Sanat Bhavsar
-
Publication number: 20230165474Abstract: A method includes determining, by a computer processor coupled to memory, data associated with a patient, the data comprising a heart rate value, a peak velocity through aortic valve value, and a stroke volume value; generating a flow waveform for the patient using the data; determining a set of candidate vascular impedance (VI) values for the patient based at least in part on the flow waveform, the set of candidate VI values comprising first and second VI values; determining a first pressure waveform using the flow waveform and the first VI value; determining a second pressure waveform using the flow waveform and the second VI value; determining a blood pressure value for the patient; determining that the first pressure waveform is a closer match to the blood pressure value than the second pressure waveform; and determining that the patient has a vascular impedance of the first VI value.Type: ApplicationFiled: February 25, 2022Publication date: June 1, 2023Inventors: Jonathan Brown, Elazer R. Edelman, Michael Murphy
-
Publication number: 20230076868Abstract: A system for completing a medical image having at least one obscured region includes an input for receiving a first classification map generated using an acquired optical coherence tomography (OCT) image having at least one obscured region, the acquired OCT image acquired using an imaging system and a pre-processing module coupled to the input and configured to create an obscured region mask. The pre-processing module also generates a second classification map that has the at least one obscured region filled in. The system also includes a generative network coupled to the pre-processing module and configured to generate a synthetic OCT image based on the second classification map and a post-processing module coupled to the generative network. The post-processing module is configured to receive the synthetic OCT image and the acquired OCT image and to generate a completed image based on the synthetic OCT image and the acquired OCT image.Type: ApplicationFiled: January 19, 2021Publication date: March 9, 2023Inventors: Max Louis OLENDER, Elazer R. EDELMAN
-
Patent number: 11574741Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).Type: GrantFiled: June 19, 2019Date of Patent: February 7, 2023Assignees: Abiomed, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.Inventors: Qing Tan, Ahmad El Katerji, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller, Sonya Sanat Bhavsar
-
Publication number: 20220257921Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.Type: ApplicationFiled: May 2, 2022Publication date: August 18, 2022Applicants: ABIOMED, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Ahmad El Katerji, Qing Tan, Christian Moyer, Alexander Ship, Sonya Sanat Bhavsar, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller
-
Patent number: 11357968Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.Type: GrantFiled: June 19, 2019Date of Patent: June 14, 2022Assignees: ABIOMED, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL INC.Inventors: Ahmad El Katerji, Qing Tan, Christian Moyer, Alexander Ship, Sonya Sanat Bhavsar, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller
-
Publication number: 20220054719Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 ?m to about 1000 ?m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.Type: ApplicationFiled: November 8, 2021Publication date: February 24, 2022Inventors: Laura Indolfi, Elazer R. Edelman, Robert S. Langer, Jeffrey W. Clark, David T. Ting, Cristina Rosa Annamaria Ferrone, Matteo Ligorio
-
Patent number: 11167066Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 ?m to about 1000 ?m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.Type: GrantFiled: February 26, 2016Date of Patent: November 9, 2021Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Laura Indolfi, Elazer R. Edelman, Robert S. Langer, Jeffrey W. Clark, David T. Ting, Cristina Rosa Annamaria Ferrone, Matteo Ligorio
-
Patent number: 11122981Abstract: A method, including: obtaining, by a processor, imaging data from a vessel; detecting, using the processor, an inner wall of the vessel based on the imaging data; identifying, using the processor, a plurality of visible edge portions of an outer wall of the vessel based on the imaging data; fitting, using the processor, a continuous surface model to the plurality of identified visible edge portions of the outer wall; and detecting, using the processor, the outer wall of the vessel based on fitting the continuous surface model to the plurality of identified visible edge portions of the outer wall such that the imaging data has defined therein a wall area between the inner wall and the outer wall of the vessel.Type: GrantFiled: May 17, 2019Date of Patent: September 21, 2021Assignee: MASSACHUSEHIS INSTITUTE OF TECHNOLOGYInventors: Max Louis Olender, Lambros Athanasiou, Elazer R. Edelman
-
Patent number: 10966826Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: GrantFiled: November 16, 2018Date of Patent: April 6, 2021Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
-
Publication number: 20200368017Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: November 16, 2018Publication date: November 26, 2020Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
-
Publication number: 20200360135Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: June 2, 2020Publication date: November 19, 2020Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
-
Publication number: 20200359911Abstract: A method, including: obtaining, by a processor, imaging data from a vessel; detecting, using the processor, an inner wall of the vessel based on the imaging data; identifying, using the processor, a plurality of visible edge portions of an outer wall of the vessel based on the imaging data; fitting, using the processor, a continuous surface model to the plurality of identified visible edge portions of the outer wall; and detecting, using the processor, the outer wall of the vessel based on fitting the continuous surface model to the plurality of identified visible edge portions of the outer wall such that the imaging data has defined therein a wall area between the inner wall and the outer wall of the vessel.Type: ApplicationFiled: May 17, 2019Publication date: November 19, 2020Inventors: Max Louis Olender, Lambros Anthanasiou, Elazer R. Edelman
-
Patent number: 10780195Abstract: Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.Type: GrantFiled: June 23, 2016Date of Patent: September 22, 2020Assignee: Massachusetts Instiitute of TechnologyInventors: Natalie Artzi, Elazer R. Edelman, Regina Kelmansky, Marc Mier Cervantes, Yi Zhang
-
Patent number: 10736914Abstract: Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.Type: GrantFiled: January 29, 2018Date of Patent: August 11, 2020Assignee: Massachusetts Institute of TechnologyInventors: Natalie Artzi, Elazer R. Edelman, Regina Kelmansky, Marc Mier Cervantes
-
Publication number: 20200146561Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).Type: ApplicationFiled: June 19, 2019Publication date: May 14, 2020Inventors: Qing Tan, Ahmad El Katerji, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller, Sonya Sanat Bhavsar
-
Publication number: 20200086022Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.Type: ApplicationFiled: June 19, 2019Publication date: March 19, 2020Inventors: Ahmad El Katerji, Qing Tan, Christian Moyer, Alexander Ship, Sonya Sanat Bhavsar, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller
-
Publication number: 20200038208Abstract: A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site.Type: ApplicationFiled: October 11, 2019Publication date: February 6, 2020Inventors: Yoram RICHTER, Elazer R. EDELMAN