Patents by Inventor Elena S. Stavridi

Elena S. Stavridi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified p53 tetramerization domains having hydrophobic amino acid substitutions
    Patent number: 6388062
    Abstract: Modified p53 tetramerization domains which do not hetero-oligomerize with native p53 tetramerization domains are described. These modified p53 tetramerization domains have one or more of the following substitutions in the region of residues 325 to 355 of human p53: Leu330 substituted with Phe; Met340 substituted with Phe; Ala347 substituted with Ile; Leu348 substituted with Met; Ala353 substituted with Leu; Gln354 substituted with Leu; Ala355 substituted with Asp. Also described are p53 proteins containing these modified p53 tetramerization domains linked to a p53 DNA binding domain. These proteins and the nucleic acid sequences encoding them, are useful in ameliorating conditions associated with inappropriate p53 function.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: May 14, 2002
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Thanos D. Halazonetis, Elena S. Stavridi