Patents by Inventor Eleuterio Lombardo

Eleuterio Lombardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mesenchymal stem cell-derived exosomes and their uses
    Patent number: 11857575
    Abstract: The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 2, 2024
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans, Javier Garcia Casado, Rebeca Blazquez Duran, Francisco Miguel Sanchez Margallo
  • Lymphocyte biomarkers for determining the clinical response to cell therapy
    Patent number: 11478511
    Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: October 25, 2022
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans
  • CRYOPRESERVATION OF STEM CELLS
    Publication number: 20220104481
    Abstract: The invention relates to methods for the cryopreservation of a stem cell population, including mesenchymal stem cells (MSCs) such as adipose-derived stromal stem cells (ASCs). More particularly, the invention relates to the use of N-acetylcysteine (NAC) in cryopreservation methods, populations of cells obtained from said methods, compositions comprising said cells and uses thereof.
    Type: Application
    Filed: February 11, 2020
    Publication date: April 7, 2022
    Applicant: TiGenix, S.A.U.
    Inventors: Eleuterio LOMBARDO DE LA CAMARA, Maitane ORTIZ VIRUMBRALES
  • MESENCHYMAL STROMAL CELLS FOR TREATING SEPSIS
    Publication number: 20200376038
    Abstract: The invention relates to the use of mesenchymal stromal cells (MSCs) for treating sepsis in a subject. The invention provides compositions, uses and methods for the treatment of sepsis.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicant: TiGenix, S.A.U.
    Inventors: Wilfried DALEMANS, Eleuterio LOMBARDO, Robert DEKKER
  • LYMPHOCYTE BIOMARKERS FOR DETERMINING THE CLINICAL RESPONSE TO CELL THERAPY
    Publication number: 20200261511
    Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 20, 2020
    Inventors: Olga DE LA ROSA, Eleuterio LOMBARDO, Wilfried DALEMANS
  • Lymphocyte biomarkers for determining the clinical response to cell therapy
    Patent number: 10660920
    Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: May 26, 2020
    Assignees: TIGENIX NV, TIGENIX S.A.U.
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans
  • MESENCHYMAL STEM CELL-DERIVED EXOSOMES AND THEIR USES
    Publication number: 20180318354
    Abstract: The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.
    Type: Application
    Filed: November 2, 2016
    Publication date: November 8, 2018
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans, Javier Garcia Casado, Rebeca Blazquez Duran, Francisco Miguel Sanchez Margallo
  • MESENCHYMAL STROMAL CELLS FOR TREATING SEPSIS
    Publication number: 20170151284
    Abstract: The invention relates to the use of mesenchymal stromal cells (MSCs) for treating sepsis in a subject. The invention provides compositions, uses and methods for the treatment of sepsis.
    Type: Application
    Filed: June 30, 2015
    Publication date: June 1, 2017
    Applicant: TiGenix S.A.U.
    Inventors: Wilfried DALEMANS, Eleuterio LOMBARDO, Robert DEKKER
  • MESENCHYMAL STROMAL CELLS FOR TREATING RHEUMATOID ARTHRITIS
    Publication number: 20170136065
    Abstract: The present invention provides a method for treating rheumatoid arthritis comprising the use of mesenchymal stromal cells.
    Type: Application
    Filed: June 30, 2015
    Publication date: May 18, 2017
    Applicant: TiGenix S.A.U.
    Inventors: Wilfried DALEMANS, Eleuterio LOMBARDO, Robert DEKKER
  • MESENCHYMAL STEM CELL-DERIVED EXOSOMES AND THEIR USES
    Publication number: 20170119682
    Abstract: The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.
    Type: Application
    Filed: November 2, 2016
    Publication date: May 4, 2017
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans, Javier Garcia Casado, Rebeca Blazquez Duran, Francisco Miguel Sanchez Margallo
  • MESENCHYMAL STEM CELL-DERIVED EXOSOMES AND THEIR USES
    Publication number: 20170121685
    Abstract: The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.
    Type: Application
    Filed: November 2, 2015
    Publication date: May 4, 2017
    Inventors: Olga DE LA ROSA, Eleuterio LOMBARDO, Wilfried DALEMANS, Javier GARCÍA CASADO, Rebeca BLÁZQUEZ DURÁN, Francisco Miguel SÁNCHEZ MARGALLO,
  • LYMPHOCYTE BIOMARKERS FOR DETERMINING THE CLINICAL RESPONSE TO CELL THERAPY
    Publication number: 20160067285
    Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
    Type: Application
    Filed: March 17, 2014
    Publication date: March 10, 2016
    Inventors: Olga DE LA ROSA, Eleuterio LOMBARDO, Wilfried DALEMANS
  • Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases
    Patent number: 9012220
    Abstract: The present invention relates to cells capable of expressing IDO, nucleic acid constructs for expression of IDO, cells comprising said constructs and methods of utilizing said cells in the treatment of diseases. In particular the present invention relates to cells which express IDO in the absence of exposure to IFN-gamma, and to their use in preparation and/or generation of immunomodulatory cells specific for an antigen.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 21, 2015
    Assignee: Cellerix S.A.
    Inventors: Dirk Buescher, Olga De La Rosa, Eleuterio Lombardo
  • METHODS AND COMPOSITIONS FOR USE IN INTRALYMPHATIC CELLULAR THERAPIES
    Publication number: 20140154274
    Abstract: The present invention provides medical uses and methods for the intralymphatic administration of cellular therapies. Further aspects of the invention provide compositions, kits and uses for the intralymphatic administration of cellular therapies.
    Type: Application
    Filed: January 12, 2012
    Publication date: June 5, 2014
    Applicants: TIGENIX NV, TIGENIX S.A.U.
    Inventors: Eleuterio Lombardo, Wilfried Dalemans
  • Methods and compositions for use in cellular therapies
    Patent number: 8679834
    Abstract: The present invention provides methods for the intralymphatic administration of cellular therapies. Further aspects of the invention provide compositions, kits and uses thereof related to such methods.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: March 25, 2014
    Assignee: TiGenix S.A.U
    Inventors: Eleuterio Lombardo, Dirk Büscher
  • STEM CELL CULTURE MEDIA AND METHODS
    Publication number: 20130295672
    Abstract: The present invention provides novel stem culture compositions and methods.
    Type: Application
    Filed: September 8, 2011
    Publication date: November 7, 2013
    Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, TiGenix, S.A.U.
    Inventors: Lourdes Planelles Carazo, Eleuterio Lombardo, Manuela Zonca
  • METHODS AND COMPOSITIONS FOR USE IN CELLULAR THERAPIES
    Publication number: 20120308585
    Abstract: The present invention provides methods for the intralymphatic administration of cellular therapies. Further aspects of the invention provide compositions, kits and uses thereof related to such methods.
    Type: Application
    Filed: July 9, 2010
    Publication date: December 6, 2012
    Applicant: CELLERIX SA
    Inventors: Eleuterio Lombardo, Dirk Büscher
  • CELLS, NUCLEIC ACID CONSTRUCTS, CELLS COMPRISING SAID CONSTRUCTS AND METHODS UTILIZING SAID CELLS IN THE TREATMENT OF DISEASES
    Publication number: 20120064031
    Abstract: The present invention relates to cells capable of expressing IDO, nucleic acid constructs for expression of IDO, cells comprising said constructs and methods of utilizing said cells in the treatment of diseases. In particular the present invention relates to cells which expresses IDO in the absence of exposure to IFN-gamma, and to their use in preparation and/or generation of immunomodulatory cells specific for an antigen.
    Type: Application
    Filed: November 6, 2009
    Publication date: March 15, 2012
    Inventors: Dirk Buescher, Olga De La Rosa, Eleuterio Lombardo
  • METHODS FOR THE PREPARATION OF ADIPOSE DERIVED STEM CELLS AND UTILIZING SAID CELLS IN THE TREATMENT OF DISEASES
    Publication number: 20120020930
    Abstract: The present invention provides a method for the preparation of adipose derived stem cells for use in cellular therapy. In further aspects the present invention provides cells produced by the method of the invention, pharmaceutical compositions and kits suitable for use in treatment of patients.
    Type: Application
    Filed: December 2, 2009
    Publication date: January 26, 2012
    Applicant: CELLERIX, S.A.
    Inventors: Dirk Buescher, Eleuterio Lombardo