Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: Waste chute devices and methods for using the same are provided. In some embodiments, a method for operating waste chutes comprises: receiving, using a hardware processor of a waste chute device, an identity associated with a user of the waste chute device; in response to receiving the identity associated with the user, allowing, using the hardware processor, a door of the waste chute device to be opened; determining, using the hardware processor, a number of items and at least one type associated with the items that have been placed in an opening of the waste chute device; determining, using the hardware processor, that the door of the waste chute device has been closed; updating, using the hardware processor, information associated with the user based on the number of items and the at least one type of items that have been placed in the opening of the waste chute device; and providing, using the hardware processor, the user with the updated information.

Abstract: The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP.

Abstract: The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP.

Abstract: The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of formula (I), some are known and others are new. The novel compounds constitute another aspect of the invention.

Abstract: The present invention provides a compound of the following formula I: R3—NH—C(?X)—P(?O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically acceptable salts, solvates, hydrates and polymorphs of said isomers and forms, wherein R1 and R2 may be the same or different and are each selected from hydrogen, acyloxyalkyl and aryl or R1 and R2 may form together with the oxygen and phosphorus atoms a dioxaphosphacycloalkane ring; X is O or S; and R3 is selected, when X is O, from bicycloalkyl, cycloalkylalkyl and substituted cycloalkyl by at least one of alkyl, amino, amidino and guanidino; and R3 is selected, when X is S, from bicycloalkyl, cycloalkylalkyl and cycloalkyl optionally substituted by at least one of alkyl, amino, amidino and guanidino; with the proviso that: when X is O, R3 is not cyclohexylmethyl, and when X is S, R3 is not cycl

Abstract: The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of formula (I), some are known and others are new. The novel compounds constitute another aspect of the invention.

Abstract: The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thixophosphpnate of formula (I). Out of the phosphonates of formula (I), some are known and others are new. The novel compounds constitute another aspect of the invention.

Abstract: The present invention provides a compound of the following formula I: R3—NH—C(?X)—P(?O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically acceptable salts, solvates, hydrates and polymorphs of said isomers and forms, wherein R1 and R2 may be the same or different and are each selected from hydrogen, acyloxyalkyl and aryl or R1 and R2 may form together with the oxygen and phosphorus atoms a dioxaphosphacycloalkane ring; X is O or S; and R3 is selected, when X is O, from bicycloalkyl, cycloalkylalkyl and substituted cycloalkyl by at least one of alkyl, amino, amidino and guanidino; and R3 is selected, when X is S, from bicycloalkyl, cycloalkylalkyl and cycloalkyl optionally substituted by at least one of alkyl, amino, amidino and guanidino; with the proviso that: when X is O, R3 is not cyclohexylmethyl, and when X is S, R3 is not c

Abstract: A method for treating patients having calcium related disorders includes using di- or tripeptide derivatives of bisphosphonates to enhance oral bioavailability of such compounds.

Abstract: Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is .dbd.O or .dbd.N--OH and n is from 3 to 24, and further wherein when Y is .dbd.O, (i) R.sub.1 is hydrogen and R.sub.2 is sodium, or (ii) R.sub.1 is sodium and R.sub.2 is methyl, and when Y is .dbd.N--OH, R.sub.1 is sodium and R.sub.2 is methyl.

Abstract: Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents .dbd.0 or .dbd.N--OH, or --OH and X represents --(CH.sub.2).sub.n --, a branched alkylene group, or a branched or straight alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atoms, wherein n is an integer from 3 to 24. Further definitions of X are included in the description.

Abstract: Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents .dbd.0 or .dbd.N--OH, or --OH; and X represents --(CH.sub.2).sub.n --, a branched alkylene group, or a branched or straight alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atoms, wherein n is an integer from 3 to 24; with the provision that when l.dbd.m.dbd.1, Y is .dbd.0, and R.sub.1 and R.sub.2 denote a lower alkyl group, n represents an integer from 9 to 20; and with the provision that when l.dbd.m.dbd.2, Y is --OH and R.sub.1 and R.sub.2 are methyl groups, n represents an integer from 9-24; and with the further provision that when l.dbd.m.dbd.2, Y is --OH and R.sub.1 and R.sub.2 are hydrogen, n represents 3, 5 or an integer from 7 to 24; or X is--(CH.sub.2).sub.p --(OCH.sub.2 CH.sub.2).sub.