Patents by Inventor Eli N. Glezer

Eli N. Glezer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKED PAIRED STRAND SEQUENCING
    Publication number: 20240150826
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Application
    Filed: January 12, 2024
    Publication date: May 9, 2024
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • DIAGNOSTIC METHODS FOR LIVER DISORDERS
    Publication number: 20240151726
    Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: January 16, 2024
    Publication date: May 9, 2024
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
  • Glomerulonephritis biomarkers
    Patent number: 11971418
    Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: April 30, 2024
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, John Kenten, Galina Nikolenko
  • Biodosimetry panels and methods
    Patent number: 11967410
    Abstract: Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: April 23, 2024
    Assignees: Meso Scale Technologies, LLC, THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • Nucleotide analogues
    Patent number: 11958877
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: April 16, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Methods for conducting multiplexed assays
    Patent number: 11951483
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: April 9, 2024
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • MODIFIED ARCHAEAL FAMILY B POLYMERASES
    Publication number: 20240101979
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: November 2, 2023
    Publication date: March 28, 2024
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Apparatus for conducting continuous interleaved assaying in a multi-well plate
    Patent number: 11940385
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: March 26, 2024
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Eli N. Glezer, Sharon West, George Sigal, Carl Stevens, Michael L. Vock
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11913071
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: February 27, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • FLOW CELL RECEIVER AND METHODS OF USE
    Publication number: 20240058821
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 22, 2024
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • COMPETITIVE METHODS AND COMPOSITIONS FOR AMPLIFYING POLYNUCLEOTIDES
    Publication number: 20240052406
    Abstract: Disclosed herein, inter alia, are methods for increasing monoclonal nucleic acid amplification products on a solid support.
    Type: Application
    Filed: August 3, 2023
    Publication date: February 15, 2024
    Inventors: Daan Witters, Eli N. Glezer
  • KIDNEY FUNCTION BIOMARKERS
    Publication number: 20240053364
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: March 27, 2023
    Publication date: February 15, 2024
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko
  • Assay cartridges and methods of using the same
    Patent number: 11896978
    Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: February 13, 2024
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
  • Imaging systems and methods useful for patterned structures
    Patent number: 11900595
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for identifying and/or quantifying features in patterns.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: February 13, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • TETHERED DETECTION ASSAYS
    Publication number: 20240044882
    Abstract: Disclosed herein, inter alia, are compositions, complexes, and methods useful for efficient multiplex assays.
    Type: Application
    Filed: August 4, 2023
    Publication date: February 8, 2024
    Inventor: Eli N. Glezer
  • Methods for in situ transcriptomics and proteomics
    Patent number: 11891656
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11891633
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Linked paired strand sequencing
    Patent number: 11891660
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Assay apparatuses, methods and reagents
    Patent number: 11892455
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: February 6, 2024
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • METHODS AND COMPOSITIONS FOR AMPLIFYING POLYNUCLEOTIDES
    Publication number: 20240035078
    Abstract: Disclosed herein, inter alia, are methods for increasing monoclonal nucleic acid amplification products on a solid support.
    Type: Application
    Filed: July 24, 2023
    Publication date: February 1, 2024
    Inventors: Daan Witters, Eli N. Glezer