Abstract: Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs based on PD-1 inhibition are also disclosed. Methods and kits useful for identifying agents useful for modulating HIV replication are also disclosed.

Abstract: Modulation of PD-1 activity in the presence or absence of an agent as measured by a gene expression profile of at least two genes is provided. Reagents, kits, methods and uses thereof for the modulation of immune function comprise the identification of modulators of PD-1 activity.

Abstract: Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs based on PD-1 inhibition are also disclosed. Methods and kits useful for identifying agents useful for modulating HIV replication are also disclosed.

Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

Abstract: A rinsing and drying apparatus of a clinical analyzer probe drain station is provided. The rinsing and drying apparatus has a group of nozzles that are offset from a longitudinal axis of a probe passage and may be inclined and oriented to provide tangentially oriented fluid-jet trajectories exiting into the sample probe passage. The offset nozzles, nozzle orientation, and cavity geometrical features of the device permit the drying capacity of probe-impinging planar air-knife jets to be maximized by stabilizing local internal fluid movement to form a swirling (e.g., helical) gas flow field directed away from a drying region and toward a vacuum exhaust. The rinsing and drying apparatus eliminates rinse water re-circulated entrainment and up-wash (spitting) during the air-knife drying operation. Therefore, the rinsing and drying apparatus significantly reduces water carryout on sampling probes thereby reducing sample/reagent dilution.

Abstract: Providing the desired volume of a liquid within a biochemical analyzer by aspirating an excess slug of liquid from a container into a probe, ejecting a portion of the excess liquid, and then dispensing the desired volume of liquid into a container.

Abstract: Reagents, kits, methods and uses thereof useful for the modulation of immune function, such as the identification of modulators of PD-1 activity, are described. Such reagents, kits, methods and uses thereof may be useful, for example, in the diagnosis, prognostication, prevention and/or treatment of immune-related diseases and/or conditions.

Abstract: Methods, uses, products and kits are described relating to monitoring, assessing and modulating immune function and more particularly memory T cell function. Methods of identifying agents for such modulation are also described, as well as uses of such agents for modulating immune function.

Abstract: Cleaning a liquid sample probe with a cleansing station having sources of air, cleansing solution, bath and shower water in a two-well cleansing body.

Abstract: Providing the desired volume of a liquid within a biochemical analyzer by aspirating an excess slug of liquid from a container into a probe, ejecting a portion of the excess liquid, and then dispensing the desired volume of liquid into a container.

Abstract: A lidstock for a open sample container having a plurality of slits to form segment intersections that facilitate penetration by an aspiration probe, the segment intersections displaced from the location for penetration by the probe.

Abstract: A circular shaped rotor to facilitate automated identification testing of microorganisms in a microbiology analyzer having two circular arrays of microwells downwardly projecting from the top of the rotor connected to a recessed central region by a plurality of microchannels formed in the upper surface and connecting the recessed central portion to the second plurality of microwells; the rotor is further adapted to be rotated by a source of rotational energy and moved throughout the analyzer using troughs formed near its outer diameter.

Abstract: A circular shaped rotor to facilitate automated identification testing of microorganisms in a microbiology analyzer having two circular arrays of microwells downwardly projecting from the top of the rotor connected to a recessed central region by a plurality of microchannels formed in the upper surface and connecting the recessed central portion to the second plurality of microwells; the rotor is further adapted to be rotated by a source of rotational energy and moved throughout the analyzer using troughs formed near its outer diameter.