Patents by Inventor Elisabeth A. Seftor

Elisabeth A. Seftor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NODAL REGULATION OF CANCER DRUG RESISTANCE GENE
    Publication number: 20200239561
    Abstract: The invention relates to combination therapeutic agents comprising an anti-cancer drug and an anti-Nodal agent for use in decreasing, suppressing and/or abrogating manifestation or appearance of cancer drug resistance in a cancer subject in need thereof. The anti-Nodal agent decreases, suppresses and/or abrogates cancer drug resistance to the anti-cancer drug in the cancer subject. A pharmaceutical composition comprising an anti-Nodal agent for use in decreasing, suppressing and/or abrogating manifestation or appearance of cancer drug resistance in a cancer subject in need thereof is disclosed. A method for prognosis of cancer patient and a diagnostic kit are also disclosed.
    Type: Application
    Filed: January 20, 2020
    Publication date: July 30, 2020
    Inventors: Mary J. C. HENDRIX, Richard E. B. Seftor, Elisabeth A. Seftor
  • Anti-nodal antibodies and methods of using same
    Patent number: 10508147
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: December 17, 2019
    Assignee: ANN & ROBERT H. LURIE CHILDREN'S HOSPITAL
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J. C. Hendrix, Elisabeth A. Seftor, Richard E. B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • Anti-nodal antibodies and methods of using same
    Patent number: 10494428
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: December 3, 2019
    Assignee: Ann & Robert H. Lurie Children's Hosp. of Chicago
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J. C. Hendrix, Elisabeth A. Seftor, Richard E. B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
    Publication number: 20180319875
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Application
    Filed: February 13, 2018
    Publication date: November 8, 2018
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J.C. Hendrix, Elisabeth A. Seftor, Richard E.B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
    Publication number: 20180298090
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 18, 2018
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J.C. Hendrix, Elisabeth A. Seftor, Richard E.B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • Anti-nodal antibodies and methods of using same
    Patent number: 9688750
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 27, 2017
    Assignee: ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J. C. Hendrix, Elisabeth A. Seftor, Richard E. B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
    Publication number: 20160130335
    Abstract: The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease.
    Type: Application
    Filed: October 7, 2015
    Publication date: May 12, 2016
    Inventors: Menotti Ruvo, Annamaria Sandomenico, Antonio Leonardi, Luca Sanguigno, Mary J.C. Hendrix, Elisabeth A. Seftor, Richard E.B. Seftor, Luigi Strizzi, Zhila Khalkhali-Ellis
  • Methods of Inhibiting Tumor Cell Aggressiveness Using The Microenvironment of Human Embryonic Stem Cells
    Publication number: 20080050362
    Abstract: The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of Nodal. The invention also provides methods of utilizing factors derived from human embryonic stem cells (hESC) and their microenvironment to treat and prevent tumor formation and progression and to inhibit tumor cell aggressiveness. The invention further provides methods of inhibiting tumor cell growth and/or treating aggressive tumors in a mammal comprising administering to the mammal, having at least one tumor cell present in its body, an effective amount of an inhibitor of Nodal activity.
    Type: Application
    Filed: July 26, 2007
    Publication date: February 28, 2008
    Applicant: CHILDREN'S MEMORIAL HOSPITAL
    Inventors: Mary Hendrix, Lynne-Marie Postovit, Richard Seftor, Elisabeth Seftor