Patents by Inventor Elisabeth Bock
Elisabeth Bock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190002517Abstract: The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion molecule (NCAM) and inducing neuroplastic and neuroprotective effects, and the use of said peptide fragments as neuritogenic agents for treatment of pathological conditions in which neuroprotection and neuroplastic changes are desired, such as brain and retina disorders.Type: ApplicationFiled: June 13, 2018Publication date: January 3, 2019Inventors: David-Paul D. Woldbye, Casper Rene Gøtzsche, Kristian Klemp, Vladimir Berezin, Elisabeth Bock
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Patent number: 10100100Abstract: The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: GrantFiled: December 13, 2016Date of Patent: October 16, 2018Assignee: University of TasmaniaInventors: Vladimir Berezin, Elisabeth Bock, Milena Penkowa
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Patent number: 10017554Abstract: The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion molecule (NCAM) and inducing neuroplastic and neuroprotective effects, and the use of said peptide fragments as neuritogenic agents for treatment of pathological conditions in which neuroprotection and neuroplastic changes are desired, such as brain and retina disorders.Type: GrantFiled: April 10, 2014Date of Patent: July 10, 2018Assignees: University of Copenhagen, Næstved HospitalInventors: David Paul D. Woldbye, Casper Rene Gøtzsche, Kristian Klemp, Vladimir Berezin, Elisabeth Bock
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Publication number: 20170226190Abstract: The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: ApplicationFiled: December 13, 2016Publication date: August 10, 2017Inventors: Vladimir Berezin, Elisabeth Bock, Milena Penkowa
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Patent number: 9518089Abstract: The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: GrantFiled: November 21, 2013Date of Patent: December 13, 2016Assignee: University of TasmaniaInventors: Vladimir Berezin, Elisabeth Bock, Milena Penkowa
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Patent number: 9359405Abstract: The present invention discloses novel peptides derived from the IL-1 receptor antagonist protein (IL1 RA), capable of binding to the cell surface IL-1 receptor 1 (IL1 R1) and interfere with the binding of IL-1 to IL1 R1. This binding thus effectively antagonizes the inflammatory effects of IL-1, such as by reducing TNF-alpha secretion from macrophages. This is of potential use as an anti-inflammatory factor throughout the human body, including the central nervous system. The use of said peptides as anti-inflammatory agents for treatment of pathological conditions wherein IL-1 plays a prominent role, such as inflammatory conditions of the body and the central nervous system, is thus an aspect of the present invention.Type: GrantFiled: March 14, 2012Date of Patent: June 7, 2016Assignee: Phlogo ApSInventors: Vladimir Berezin, Elisabeth Bock
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Publication number: 20160060320Abstract: The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion molecule (NCAM) and inducing neuroplastic and neuroprotective effects, and the use of said peptide fragments as neuritogenic agents for treatment of pathological conditions in which neuroprotection and neuroplastic changes are desired, such as brain and retina disorders.Type: ApplicationFiled: April 10, 2014Publication date: March 3, 2016Applicants: NÆSTVED HOSPITAL, UNIVERSITY OF COPENHAGENInventors: David Paul D. Woldbye, Casper Rene Gøtzsche, Kristian Klemp, Vladimir Berezin, Elisabeth Bock
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Publication number: 20150252075Abstract: The present invention relates to peptides derived from neuroplastin which are capable of inducing neurite outgrowth by modulating intracellular calcium concentration and activity of intracellular signalling molecules such as Akt, Erk1/2 and CREB through binding and/or modulation of receptor tyrosine kinases including but not limited to Fibroblast Growth Factor receptors (FGFRs). The peptides are derived from neuroplastin or fragments thereof. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein neuroplastin and/or receptor tyrosine kinases, including but not limited to FGFRs, play a prominent role.Type: ApplicationFiled: September 15, 2014Publication date: September 10, 2015Inventors: Vladimir Berezin, Elisabeth Bock, Vladislav Soroka
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Publication number: 20150238556Abstract: The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.Type: ApplicationFiled: May 13, 2015Publication date: August 27, 2015Inventors: Vladimir Berezin, Elisabeth Bock
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Patent number: 9044428Abstract: The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.Type: GrantFiled: November 19, 2012Date of Patent: June 2, 2015Assignee: Neoloch ApSInventors: Vladimir Berezin, Elisabeth Bock
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Publication number: 20140234294Abstract: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.Type: ApplicationFiled: December 24, 2013Publication date: August 21, 2014Applicant: Kobenhavns UniversitetInventors: Vladimir Berezin, Elisabeth Bock, Artur Kochoyan
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Publication number: 20140179614Abstract: The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: ApplicationFiled: November 21, 2013Publication date: June 26, 2014Applicant: University of TasmaniaInventors: Vladimir Berezin, Elisabeth Bock, Milena Penkowa
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Publication number: 20140073556Abstract: The present invention discloses novel peptides derived from the IL-1 receptor antagonist protein (IL1 RA), capable of binding to the cell surface IL-1 receptor 1 (IL1 R1) and interfere with the binding of IL-1 to IL1 R1. This binding thus effectively antagonises the inflammatory effects of IL-1, such as by reducing TNF-alpha secretion from macrophages. This is of potential use as an anti-inflammatory factor throughout the human body, including the central nervous system. The use of said peptides as anti-inflammatory agents for treatment of pathological conditions wherein IL-1 plays a prominent role, such as inflammatory conditions of the body and the central nervous system, is thus an aspect of the present invention.Type: ApplicationFiled: March 14, 2012Publication date: March 13, 2014Applicant: SERODUS ASAInventors: Vladimir Berezin, Elisabeth Bock
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Patent number: 8637465Abstract: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.Type: GrantFiled: May 27, 2009Date of Patent: January 28, 2014Assignee: Kobenhavns UniversitetInventors: Vladimir Berezin, Elisabeth Bock, Artur Kochoyan
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Patent number: 8618060Abstract: The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: GrantFiled: February 12, 2007Date of Patent: December 31, 2013Assignee: University of TasmaniaInventors: Vladimir Berezin, Elisabeth Bock, Milena Penkowa
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Patent number: 8546321Abstract: The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.Type: GrantFiled: November 17, 2009Date of Patent: October 1, 2013Assignee: Kobenhavns UniversitetInventors: Elisabeth Bock, Vladimir Berezin
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Patent number: 8470964Abstract: The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,11 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity or survival of cells. Further, the present invention relates to the use of the compounds for production of a medicament for treatment of conditions and diseases, in which NCAM or FGFR play a prominent role.Type: GrantFiled: November 28, 2008Date of Patent: June 25, 2013Assignee: Enkam Pharmaceuticals A/SInventors: Vladimir Berezin, Elisabeth Bock, Soren Ebdrup, Boris Klementiev
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Patent number: 8329652Abstract: The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.Type: GrantFiled: May 8, 2006Date of Patent: December 11, 2012Assignee: Neoloch ApSInventors: Vladimir Berezin, Elisabeth Bock
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Publication number: 20120141451Abstract: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.Type: ApplicationFiled: May 27, 2009Publication date: June 7, 2012Inventors: Vladimir Berezin, Elisabeth Bock, Artur Kochoyan
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Patent number: 8138148Abstract: The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.Type: GrantFiled: August 15, 2006Date of Patent: March 20, 2012Assignee: Copenhagen UniversityInventors: Elisabeth Bock, Vladimir Berezin