Patents by Inventor Elisabetta Groaz

Elisabetta Groaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL 6-SUBSTITUTED 7-DEAZAPURINES AND CORRESPONDING NUCLEOSIDES AS MEDICAMENTS
    Publication number: 20230104311
    Abstract: The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.
    Type: Application
    Filed: February 17, 2020
    Publication date: April 6, 2023
    Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Piet HERDEWIJN, Elisabetta GROAZ, Li QINGFENG
  • Prodrugs of nucleoside phosphonates
    Patent number: 11040047
    Abstract: The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 22, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Graciela Andrei, Steven De Jonghe, Elisabetta Groaz, Piet Herdewijn, Min Luo, Dominique Schols, Robert Snoeck
  • NOVEL PRODRUGS OF NUCLEOSIDE PHOSPHONATES
    Publication number: 20200016180
    Abstract: The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
    Type: Application
    Filed: March 21, 2018
    Publication date: January 16, 2020
    Inventors: Graciela Andrei, Steven De Jonghe, Elisabetta Groaz, Piet Herdewijn, Min Luo, Dominique Schols, Robert Snoeck