Patents by Inventor Elisabetta Mueller

Elisabetta Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for inhibiting tumor cell growth
    Patent number: 7635708
    Abstract: The present invention is based on the finding that activation of PPAR? plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR? agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proliferation of such cells.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: December 22, 2009
    Assignee: Dana-Farber Cancer Institute
    Inventors: Bruce M. Spiegelman, Elisabetta Mueller, Pasha Sarraf, Soner Altiok, Peter Tontonoz, Samuel Singer
  • Methods and pharmaceutical compositions for inhibiting tumor cell growth
    Publication number: 20030144330
    Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.
    Type: Application
    Filed: December 19, 2002
    Publication date: July 31, 2003
    Inventors: Bruce M. Spiegelman, Elisabetta Mueller, Pasha Sarraf, Soner Altiok, Peter Tontonoz, Samuel Singer
  • Methods and pharmaceutical compositions for inhibiting tumor cell growth
    Patent number: 6552055
    Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: April 22, 2003
    Assignee: Dana-Farber Cancer Institute
    Inventors: Bruce M. Spiegelman, Elisabetta Mueller, Pasha Sarraf, Soner Altiok, Peter Tontonoz, Samuel Singer
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING TUMOR CELL GROWTH
    Publication number: 20020006950
    Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.
    Type: Application
    Filed: September 4, 1997
    Publication date: January 17, 2002
    Applicant: Dana-Farber Cancer Institute
    Inventors: BRUCE M. SPIEGELMAN, SONER ALTIOK, ELISABETTA MUELLER, PASHA SARRAF, PETER TONTONOZ
  • Methods and pharmaceutical compositions for inhibiting tumor cell growth
    Patent number: 6242196
    Abstract: A method for inhibiting proliferation of a PPAR &ggr;-responsive hyperproliferative cell which comprises the step of contacting the cell with (I) an inhibitory amount of a PPAR&ggr; agonist and (II) a MAP kinase inhibitor is disclosed. A method for treating or prophylactically preventing in an animal subject a disorder characterized by unwanted proliferation of PPAR&ggr;-responsive hyperproliferative cells which comprises administering to the subject (I) an inhibitory amount of a PPAR&ggr; agonist and (II) a MAP kinase inhibitor is also disclosed. Pharmaceutical compositions comprising a therapeutically effective amount of a PPAR&ggr; agonist and a MAP kinase inhibitor are disclosed for use in the methods.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: June 5, 2001
    Assignee: Dana-Farber Cancer Institute
    Inventors: Bruce M. Spiegelman, Soner Altiok, Elisabetta Mueller, Pasha Sarraf, Peter Tontonoz