Abstract: Guanidine-based poly (amidoamine) polymers of formula (I): wherein n is an integer between 3 and 400; R1 is H, C1-6 alkyl; or taken together with the N atoms to which is bound and R2 is a piperazinic ring; R2 is C2-6 alkylen; C5-6 cycloalkylen; CH—COOH, CH—COOR, wherein R is C1-4 alkyl, phenyl or benzyl; R3 is —(CH2)p-HN—C(NH2)?NH, wherein p is an integer 1 to 6; for use as antiviral agents in the prevention and/or treatment of viral infections in a mammal, preferably a human subject.

Abstract: Guanidine-based poly (amidoamine) polymers of formula (I): wherein n is an integer between 3 and 400; R1 is H, C1-6 alkyl; or taken together with the N atoms to which is bound and R2 is a piperazinic ring; R2 is C2-6 alkylen; C5-6 cycloalkylen; CH—COOH, CH—COOR, wherein R is C1-4 alkyl, phenyl or benzyl; R3 is —(CH2)p-HN—C (NH2)?NH, wherein p is an integer 1 to 6; for use as antiviral agents in the prevention and/or treatment of viral infections in a mammal, preferably a human subject.

Abstract: There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.

Abstract: The invention provides compositions comprising a polyamidoamine (PAA) polymer comprising a pendant disulphide, sulphydryl, or activated sulphydryl moiety, and methods for their manufacture. The invention extends to the use of such polyamidoamine polymers to form cross-linked compositions, and hydrogels comprising the same, and the use of such compositions in various biological and non-biological applications, such as the delivery of biomolecules to target sites, and for tracking fluid flows. The invention also provides carrier particles, which may be used to deliver biomolecules, and to methods of treatment. The invention also provides a fluid tracking system for monitoring fluid flow.

Abstract: Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of ?-, ?-, or ?-cyclodextrins and amines to bisacrylamides.

Abstract: Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of ?-, ?-, or ?-cyclodextrins and amines to bisacrylamides.

Abstract: The invention provides compositions comprising a polyamidoamine (PAA) polymer comprising a pendant disulphide, sulphydryl, or activated sulphydryl moiety, and methods for their manufacture. The invention extends to the use of such polyamidoamine polymers to form cross-linked compositions, and hydrogels comprising the same, and the use of such compositions in various biological and non-biological applications, such as the delivery of biomolecules to target sites, and for tracking fluid flows. The invention also provides carrier particles, which may be used to deliver biomolecules, and to methods of treatment. The invention also provides a fluid tracking system for monitoring fluid flow.

Abstract: There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.

Abstract: The present invention refers to segment copolymers comprising segments “A” having polyvinylpyrrolidone (PVP) structure and segments “B” having a polyester 5 structure and the process for their preparation and their use.

Abstract: The invention relates to block copolymers of general formula (I)--?--O--CO--O--A--O--CO--O--B--!.sub.a -- (I)where a is an integer between 2 and 300 inclusive;A and B, which may be the same or different, are blocks which can be obtained by reaction between a bis(chloroformate) of oligomeric poly(caprolactone) and a polyester residue of formula (II)HO--?--R.sub.1 --CO--O!.sub.x --?--R.sub.2 --CO--O--!.sub.y --H (II)where R.sub.1 and R.sub.2, which may be the same or different, are each an aliphatic hydrocarbon residue with a linear or branched chain having from 1 to 4 carbon atoms; x and y are integers from 1 to 50, in any possible ratio from 0 to 1;the groups --R.sub.1 --COO-- and --R.sub.2 --COO-- being randomly distributed in the polyester residue.

Abstract: Polyesterpolycarbonates of formula (I) ##STR1## wherein a is an integer from 2 to 300; R.sub.1 and R.sub.2, which can be the same or different, are each a polyester residue of formula (II) ##STR2## with x and y being integers from 0 to 100, and the ratio of (x/x+y)*100 being between 0 and 100, with the proviso that x and y are not 0 at the same time; R.sub.3 and R.sub.4 being aliphatic hydrocarbon residues of 1 to 4 carbon atoms; R.sub.5 being an aliphatic hydrocarbon residue having from 2 to 18 carbon atoms or a cycloaliphatic hydrocarbon residue having from 3 to 8 carbon atoms; or a polyoxyalkylene residue of formula (III): ##STR3## wherein R.sub.6 is hydrogen or methyl, n is an integer from 1 to 3 and m is an integer from 1 to 200; and the two --R.sub.3 --COO and --R.sub.4 --COO groups are randomly distributed in the polyester residue, with the polyesterpolycarbonates of formula (I) having an intrinsic viscosity of greater than 0.45 dl/g when measured in chloroform at 32.degree. C.

Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein --Z--X--Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.

Abstract: A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas ##STR1## wherein R and R.sup.1 are C.sub.1 to C.sub.4 alkyl or substituted alkyl; n is 0 to 20; R.sup.II is ethylene; R.sup.III is C.sub.1 to C.sub.24 alkylene or substituted alkylene; and R.sup.IV is C.sub.1 to C.sub.4 alkyl or substituted alkyl; can be prepared by polymerizing an N-vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.

Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein -Z-X-Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.

Abstract: Polycarbonates of formula (I) wherein a is an integer from 2 to 300; R.sup.1 and R.sup.2 are the same or different and are independently a polyester residue of formula (III) wherein x and y are integers from 1 to 50, R.sup.4 and R.sup.5, which are the same or different, are aliphatic straight or branched hydrocarbon chains having from 1 to 4 carbon atoms, R.sup.6 is an aliphatic or alicyclic straight or branched chain having from 2 to 18 carbon atoms, or a polyoxyalkylene residue of formula (II), the two groups --R.sup.4 --COO and --R.sup.5 --COO being randomly distributed in the polyester residue, x and y being in any possible ratio from 0 to 100, are synthesized by reacting dihydroxy compounds with 1,1'-carbonyldiimidazole. They are useful for the preparation of bioerosible matrices for biologically active compounds.