Abstract: The present invention relates to a device, system and a method for optimizing syringe based drug delivery profile with a treatment element and in particular, to such a device, system and method in which optimization is based on a plurality of data that directly and/or indirectly affect the optimization of the drug delivery profile. The device facilitating syringe based drug delivery, by optimizing drug delivery of the injected drug, records user's activity, and data relative to drug injections, comprising a disposable unit configured for a single use period and a rechargeable reusable unit having electronics comprising a sensor module.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO to from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

Abstract: A device and method for delivering a therapeutic substance to the body of a mammal may include a pump adapter, a pump, and an infusion set having a distal connector and a proximal connector. The proximal connector and the pump adapter have connecting electrical contacts which can be connected to one another in a single action when the proximal connector and pump are being secured to the pump adapter. The distal connector of the infusion set can be connected to a catheter housing, which can be secured to the mammal's skin. The distal connector and the catheter housing have additional connecting electrical contacts which can be connected to one another in a single action when connecting the distal connector to the catheter housing.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO to from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

Abstract: A device and method for delivering a therapeutic substance to the body of a mammal are provided. The device includes a pump adapter, a pump, and an infusion set having a distal connector and a proximal connector. The proximal connector and the pump adapter have connecting electrical contacts which can be connected to one another in a single action when the proximal connector and pump are being secured to the pump adapter. The distal connector of the infusion set can be connected to a catheter housing, which can be secured to the mammal's skin. The distal connector and the catheter housing have additional connecting electrical contacts which can be connected to one another in a single action when connecting the distal connector to the catheter housing.

Abstract: The present invention relates to a device, system and a method for optimizing syringe based drug delivery profile with a treatment element and in particular, to such a device, system and method in which optimization is based on a plurality of data that directly and/or indirectly affect the optimization of the drug delivery profile. The device facilitating syringe based drug delivery, by optimizing drug delivery of the injected drug, records user's activity, and data relative to drug injections, comprising a disposable unit configured for a single use period and a rechargeable reusable unit having electronics comprising a sensor module.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

Abstract: A luer-type connector comprising a male-component formed with a locking nozzle having a coaxially extending nozzle lumen, and a locking collar rotatable over said nozzle. The locking collar has a rear end and is formed with an internal thread for screw coupling with a corresponding thread of a radially extending annular lug of a mating female-component of the connector. The nozzle is formed with a ridge having a radially extending abutting wall surface facing the rear end of the locking collar and a peripheral surface extending forward from the abutting wall. An annular rim behind the abutting wall has a first diameter. An annular notch intermediate the abutting wall and the annular rim has a second diameter lesser than that of the first diameter. The locking collar is formed with a radially extending wall surface engageable with the abutting wall surface of the ridge. And an annular bulge behind the radial wall surface has a third diameter lesser than the first diameter.

Abstract: A luer-type connector comprising a male-component formed with a locking nozzle having a co-axially extending lumen, and a locking collar rotatable over the nozzle and having a rear end, and formed with an internal thread for screw coupling with a radially extending annular lug of a mating female-component of the luer-type connector. The nozzle is formed with ridge having a rear, radially extending abutting wall surface terminating at an acute edge. The locking collar is formed with a ridge-engaging portion consisting of a first wall surface rearwardly tapering, and a second wall surface radially extending and adapted for engagement with the abutting wall surface of the ridge, whereby the first wall surface is adapted for frictional displacement along the acute edge and the second wall surface prevents further forward axial displacement of the locking collar with respect to the nozzle.