Abstract: Disclosed herein are disposable devices for measuring sweat having low dead volumes and allowing a quick sensory response. Also disclosed herein are methods of making and using such devices.

Abstract: A patient interface system to treat a respiratory disorder of a patient, the patient interface system comprising: a positioning and stabilising structure including a back portion and a pair of upper straps extending from the back portion; and a patient interface including a patient interface frame and a pair of rigidiser arms each connected to the patient interface frame at a connection point located in a plane substantially parallel to the patient's Frankfort horizontal plane, the pair of rigidiser arms further including a pair of upper attachment points, wherein the pair of upper straps are adapted to be releasably attached to the pair of upper attachment points such that, when donned by the patient, the pair of upper straps are vertically offset relative to the upper attachment points and substantially parallel to the patient's Frankfort horizontal plane, and wherein the patient interface does not include a forehead support.

Abstract: A system, device, and method for detecting leaks near an emitter is disclosed. The method includes (i) receiving, from one or more mobile sensors, a first stream of information indicative of a leak state, (ii) determining that an initial leak state exists based at least in part on the first stream of information indicative of the leak state, (iii) receiving a second stream of information indicative of a no-leak state, (iv) using a statistical model to determine that the leak state has ended based at least in part on the first stream of information and the second stream of information, (v) receiving a third stream of information indicative of the leak state, and (vi) determining that a new leak state exists, wherein the new leak state is a distinct leak state from the initial leak state.

Abstract: The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ?FolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.

Abstract: Among other things, the present disclosure relates to re-purposing used lithium-ion batteries. The present disclosure includes treating an electrode using a solvent prior to electrochemically relithiating the electrode. In some embodiments, the relithiation may be done using a roll-to-roll device, wherein the electrode may be secured on a first pin and a second pin, then it may be unwound and submerged in an electrolyte solution. Lithium ions may be inserted into the electrode using a voltage. The layer of lithium may provide lithium ions to the electrode.

Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.

Abstract: A system, device, and method for sensing air quality with a sensor platform is disclosed. The method includes (i) directing a set of mobile sensors to a coarse region wherein the coarse region has coarse size based on variance of prior air quality measurements taken at locations within a vicinity of the coarse region, and (ii) directing the set of mobile sensors to a fine region wherein the fine region has a fine size based on variance of prior air quality measurements taken at locations within a vicinity of the fine region. The variance of air quality measurements associated with the fine region is greater than a variance of air quality measurements associated with the coarse region.

Abstract: The disclosure provides methods and systems for determining an emotional fitness metrics for users. A physiological parameter of the user is measured during a group activity using at least one biosensor to acquire a measured signal. The measured signal of the user is compared to a measured signal for the physiological parameter of one or more additional users as measured when the one or more additional users perform the group activity. An emotional connectivity may be calculated based on a synchronicity of the measured signal of the user with the measured signal of the one or more additional users, as well as a cognitive appraisal metric, a resilience metric and an emotional fitness metric. Connectivity values for user pairings for a group activity can be computed based a synchronicity in a time-series correlation for the physiological parameters for permutations of the user pairings for the group activity.

Abstract: A method for training a control system model includes introducing a simulated fault into a software simulation of a physical system and generating emulated sensor data based on the simulated fault, where the emulated sensor data emulates output from one or more sensors of the physical system. The method further includes obtaining output data from a test control system provided with the emulated sensor data, where the test control system emulates a control system of the physical system and tagging the output data with the simulated fault to create training data. The method further includes utilizing the training data to train the control system model, where the control system model is a machine learning model for use with the control system of the physical system during operation of the physical system.

Abstract: A system, device, and method for sensing air quality with a sensor platform is disclosed. The method includes (i) directing an air quality measurement system to a predicted high information region wherein the predicted high information region is determined based on high variance of prior air quality measurements taken at different times, (ii) directing the air quality measurement system to a predicted low information region wherein the predicted low information region is determined based on low variance of prior air quality measurements taken at different times. The air quality measurement system is preferentially directed to the predicted high information region.

Abstract: The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1 or Compound No. 2: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: The present disclosure relates to methods of purifying T cells, to T cells and T cell products produced by the methods, and use of the cells and products for therapy. In certain embodiments, the present disclosures provides a method of purifying T cells. The method comprises subjecting a medium comprising the T cells to inertial microfluidic fractionation and obtaining a fraction comprising purified T cells.

Abstract: Logged data from an autonomous vehicle is processed to generate augmented data. The augmented data describes an actor in an environment of the autonomous vehicle, the actor having an associated actor type and an actor motion behavior characteristic. The augmented data may be varied to create different sets of augmented data. The sets of augmented data can be used to create one or more simulation scenarios that in turn are used to produce machine learning models to control the operation of autonomous vehicles.

Abstract: Disclosed embodiments relate to a wound dressing which can generate nitric oxide. The wound dressing may include a cover layer, an activator layer such as an acid providing layer and nitric oxide source layer, such as a nitrite providing layer. The activator layer may include acidic groups and may be hydrogel, xerogel, or other suitable material. The activator layer may include a copolymer of monomers with one or more covalently linked multifunctional groups.

Abstract: The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ?FolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.

Abstract: Disclosed embodiments relate to a wound dressing which can generate nitric oxide. The wound dressing may include a cover layer, an activator layer such as an acid providing layer and nitric oxide source layer, such as a nitrite providing layer. The activator layer may include acidic groups and may be hydrogel, xerogel, or other suitable material. The nitric oxide source layer may include a nitrite salt. Nitrite ions of the nitric oxide source layer may react with the acidic groups of the activating layer to generate nitric oxide. The activating layer may include a window at the center, and a central absorbent material may be positioned at the window. Various separating layers may also be incorporated into the dressing to control the interaction between activating layer and nitric oxide source layer.

Abstract: Disclosed embodiments relate to a wound dressing which can generate nitric oxide. The wound dressing comprises a cover layer, an acid providing layer and a nitrite providing layer. The acid providing layer comprises acidic groups and may be hydrogel or Xerogel. The nitrite providing layer comprises a nitrite salt. The wound dressing may also include other layers, one or more acquisition distribution layers or masking layers. The masking layers can at least partially prevent visualization of the layer below the masking layer. Nitrite ions of the nitrite providing layer may react with the acidic groups of the acid providing layer to generate nitric oxide. The acid providing layer further includes one or more material layers to reduce the adhesiveness of the acid providing layer. The acid providing layer can also include perforations.

Abstract: An edible chew is formulated for oral consumption by a human child and includes an expanded pre-gelatinized cereal flour matrix. A method of (i) providing teething support to a human child who is teething and/or (ii) soothing, calming and/or delivering an active ingredient to a human child can include administering the edible chew to the human child. Methods of making the edible chew are provided, for example by modified extrusion; and also a system including the edible chew and further including a holder configured to attach to the edible chew; a product including a packaging and further including the edible chew; and a product including a container housing a plurality of the edible chews, and the plurality of edible chews are individually packaged.

Abstract: Logged data from an autonomous vehicle is processed to generate augmented data. The augmented data describes an actor in an environment of the autonomous vehicle, the actor having an associated actor type and an actor motion behavior characteristic. The augmented data may be varied to create different sets of augmented data. The sets of augmented data can be used to create one or more simulation scenarios that in turn are used to produce machine learning models to control the operation of autonomous vehicles.

Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.