Abstract: The present invention relates to GH61 polypeptide variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Abstract: The present disclosure generally relates target cancer cell specific immunotherapy compositions, methods of making and use thereof. Also provided in the disclosure are methods of treating a cancer in a subject in need thereof.

Abstract: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.

Abstract: Biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with a biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.

Abstract: Embodiments disclosed herein relate to a garment system including at least one sensor and at least one actuator that operates responsive to sensing feedback from the at least one sensor to cause a flexible compression garment to selectively constrict or selectively dilate, thereby compressing or relieving compression against at least one body part of a subject. Such selective constriction or dilation can improve muscle functioning or joint functioning during use of motion-conducive equipment, such as an exercise bike or rowing machine.

Abstract: In an embodiment, a computer-implemented process comprises accessing a plurality of digitally stored, unstructured medical diagnostic data; digitally displaying a first subset of the medical diagnostic data, the first subset of the medical diagnostic data including at least a first set of diagnostic reports, using a computer display device, concurrently with digitally displaying one or more quality control checklists that are specific to a medical discipline represented in the first set of diagnostic reports; receiving digital input specifying one or more errors in the first set of diagnostic reports and digitally storing the digital input in association with the first subset of medical diagnostic data; training a hierarchical Bayesian machine learning model using the digital input and the first subset of medical diagnostic data; evaluating the hierarchical Bayesian machine learning model, after training, for a second subset of the medical diagnostic data, the second subset being different from the first subs

Abstract: Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to immune checkpoint inhibitors. In certain embodiments, compositions herein can have at least one nanoparticle formed of Prussian blue materials and, optionally, one or more CD137 agonists. In other embodiments, methods of treating tumors herein can include administering an effective amount of at least photothermal therapy agent in combination with at least one CD137 agonist separately or in a combination therapy/combination composition.

Abstract: In an embodiment, a nerve stimulation system includes a headset and an earpiece which includes two or more ear-contacting elements, for example an ear canal insert, and a concha insert. Ear-contacting elements may be mounted onto an earpiece housing have projecting mounting structures, which provide mechanical and electrical connection between ear-contacting elements and housing through various materials and configurations. In an embodiment, a nerve stimulation system includes a neural stimulation subsystem including neural stimulation device control circuitry for use in combination with a personal computing device to control a neural stimulation device.

Abstract: A closure with tamper evident features is disclosed.

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract: Configuration technologies for apportioning resources and communicating indications of potential or actual incentives based on one or more measurements or other objective indications that therapeutic components have been administered to an individual, other attributes of the therapeutic components or the individual, or other such determinants. Techniques for apportioning resources cost-effectively (between providers and other parties, e.g.) and for facilitating or handling implementations thereof or output therefrom.

Abstract: Embodiments disclosed herein are directed to personal therapy and exercise systems as well as to methods related thereto. For example, a personal therapy system can be a modular system that can include multiple therapy gear modules.

Abstract: In an embodiment, a computer-implemented process comprises accessing a plurality of digitally stored, unstructured medical diagnostic data; digitally displaying a first subset of the medical diagnostic data, the first subset of the medical diagnostic data including at least a first set of diagnostic reports, using a computer display device, concurrently with digitally displaying one or more quality control checklists that are specific to a medical discipline represented in the first set of diagnostic reports; receiving digital input specifying one or more errors in the first set of diagnostic reports and digitally storing the digital input in association with the first subset of medical diagnostic data; training a hierarchical Bayesian machine learning model using the digital input and the first subset of medical diagnostic data; evaluating the hierarchical Bayesian machine learning model, after training, for a second subset of the medical diagnostic data, the second subset being different from the first subs

Abstract: Embodiments disclosed herein relate to a garment system including at least one sensor and at least one actuator that operates responsive to sensing feedback from the at least one sensor to cause a flexible compression garment to selectively constrict or selectively dilate, thereby compressing or relieving compression against at least one body part of a subject. Such selective constriction or dilation can improve muscle functioning or joint functioning during use of motion-conducive equipment, such as an exercise bike or rowing machine.

Abstract: Systems and methods are described for monitoring compression applied by a compression bandage to a body portion of an individual. A system embodiment includes, but is not limited to, a deformable substrate integrated with a textile configured to conform to a body portion; a sensor assembly coupled to the deformable substrate, the sensor assembly including one or more strain gauges configured to generate one or more sense signals associated with a strain of the textile; circuitry operably coupled to the sensor assembly and configured to receive the one or more sense signals associated with the strain of the textile; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals responsive to instruction by the circuitry, the one or more communication signals associated with the strain of the textile.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract: Embodiments disclosed herein relate to methods, devices, and computer systems thereof for automated data collection from a subject. In certain embodiments, one or more characteristics of a subject are sensed, and the subject is given a queue status indicator based on a comparison of the subject's one or more sensed characteristics with corresponding sensed characteristics from other subjects. In one embodiment, the subject is a healthcare worker and the system, methods, and devices are utilized to evaluate the overall health of the worker as part of the check-in process for work.

Abstract: Breast monitoring systems are described including a breast sensor device having a substrate fabricated to substantially conform to one or more breasts of a subject, dynamically bendable optical fibers, and a connector; a light source configured to operably couple with the optical fibers through the connector; a photodetector configured to operably couple with the optical fibers through the connector and positioned to detect light transmission through the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, the circuitry including input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry.

Abstract: Devices, systems, and methods that may be used to controllably deliver alcohol to a subject using an inhaler, wherein the inhaler may include a housing having a flow channel coupled to an ethanol-containing inhalant reservoir, an actuator configured to facilitate release of the inhalant, a constituent sensor, and a control unit. The control unit may accept parameters associated with the subject, create an inhalant delivery regime, and control operation of the actuator based at least partially on a sensed constituent level to facilitate release of an ethanol-containing inhalant from the reservoir into the flow channel in accordance with the regimen.