Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The present disclosure embraces a system, methods and computer program products for the intelligent on-boarding, support, education of supervised resource account users. The systems described herein allow for intelligent linkage of supervised resource accounts with existing accounts of a supervising user, creating tools for enhanced transfer of resources to a supervised user. The system offers interactivity and education opportunity along with resource transfers by determining resource allocation recommendations and providing goal-tracking capabilities.

Abstract: The present disclosure embraces a system, methods and computer program products for the intelligent on-boarding, support, education of non-conventional resource account users. In particular, the present disclosure includes tools for aggregation and intelligent data sharing between multiple users and associated resource accounts in order to generate a comparison between resource accounts and identify and incentivize potential earning opportunities. The competitive comparison may be continuously updated as earning opportunities are completed by the various users, and educational modules are provided via a resource account interface related to various topics of resource management responsibility for guided and reinforced learning.

Abstract: The present disclosure embraces a system, methods and computer program products for the intelligent onboarding, support, education of supervised resource account users. The system, methods, and computer program products provide innovative tools for the development and management of supervised user resource accounts by a supervising user, and various embodiments providing unique pathways for resource management and education via the use of the disclosed resource management system.

Abstract: A geospatial modeling system includes a display, a geospatial database, and a processor. The processor generates a model based upon a single optical image and a digital elevation model (DEM), and without registration of multiple optical images. The processor also generates time-lapsed models based upon single time-lapsed optical images and the DEM, and without registration of multiple time-lapsed optical images. Regions of interest are user selected from the time-lapsed models, and are displayed along with the model.

Abstract: A geospatial modeling system includes a display, a geospatial database, and a processor. The processor generates a model based upon a single optical image and a digital elevation model (DEM), and without registration of multiple optical images. The processor also generates time-lapsed models based upon single time-lapsed optical images and the DEM, and without registration of multiple time-lapsed optical images. Regions of interest are user selected from the time-lapsed models, and are displayed along with the model.

Abstract: A finger protecting device for use during manicure work having a top surface and a bottom surface in a meniscus shape so that when the meniscus shape is placed next to a cuticle it masks the skin adjacent to the nail, and a second sheet of nonporous material having two side extensions, both extending outward from the platform in the same general direction, so that when the platform is positioned under the bottom surface of a nail with its top surface facing the bottom surface of the nail, the side extensions extend around the nail, leaving the upper surface of the nail exposed while covering the skin adjacent to the nail.

Abstract: The present invention relates to the identification of a gene encoding the protein glutathione S-transferase pi2 as being correlated with the susceptibility to neurotoxicity and concomitantly the risk to develop Parkinson's disease. Based on this correlation, various methods are disclosed, including determining the amount of the one or more glutathione S-transferase present in a biological sample in response to an environmental toxin, to assess the risk to develop Parkinson's disease.