Patents by Inventor Elizabeth Jayne Wallace

Elizabeth Jayne Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified enzymes
    Patent number: 11965183
    Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: April 23, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, Rebecca Victoria Bowen, Mark Bruce, Lakmal Jayasinghe, Joseph Hargreaves Lloyd, Szabolcs Soeroes, Elizabeth Jayne Wallace, Christopher Peter Youd
  • MUTANT PORE
    Publication number: 20240117422
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
    Type: Application
    Filed: May 5, 2023
    Publication date: April 11, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • Protein pores
    Patent number: 11945840
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: April 2, 2024
    Assignees: VIB VZW, Vrije Universiteit Brussel, Oxford Nanopore Technologies PLC
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
  • METHOD
    Publication number: 20240060126
    Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 22, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Jonathan Bankes Pugh, Richard George Hambley, Neil Roger Wood, Clive Gavin Brown, James White, Andrew John Heron, Mark John Bruce, Christopher Peter Youd, Rebecca Victoria Bowen
  • Mutant lysenin pores
    Patent number: 11845780
    Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: December 19, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Mark Bruce, James Anthony Clarke, Andrew John Heron, Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • Modified nanopores, compositions comprising the same, and uses thereof
    Patent number: 11840556
    Abstract: Provided herein relate to modified or mutant forms of secretin and compositions comprising the same. In particular, the modified or mutant forms of secretin permits efficient capture and/or translocation of an analyte through the modified or mutant secretin nanopores. Methods for using unmodified secretin or the modified or mutant forms of secretin and compositions, for example, for characterizing an analyte, e.g., a target polynucleotide, are also provided.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 12, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh
  • MODIFIED NANOPORES, COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20230272017
    Abstract: Provided herein relate to modified or mutant forms of secretin and compositions comprising the same. In particular, the modified or mutant forms of secretin permits efficient capture and/or translocation of an analyte through the modified or mutant secretin nanopores. Methods for using unmodified secretin or the modified or mutant forms of secretin and compositions, for example, for characterizing an analyte, e.g., a target polynucleotide, are also provided.
    Type: Application
    Filed: October 11, 2022
    Publication date: August 31, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh
  • Method of improving the movement of a target polynucleotide with respect to a transmembrane pore
    Patent number: 11739377
    Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: August 29, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Jonathan Bankes Pugh, Richard George Hambley, Neil Roger Wood, Clive Gavin Brown, James White, Andrew John Heron, Mark Bruce, Christopher Peter Youd, Rebecca Victoria Bowen
  • MODIFIED HELICASES
    Publication number: 20230227799
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 18, 2022
    Publication date: July 20, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • MODIFIED HELICASES
    Publication number: 20230212535
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 17, 2022
    Publication date: July 6, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Mutant pore
    Patent number: 11685949
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: June 27, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • NOVEL PROTEIN PORES
    Publication number: 20230079731
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: September 16, 2022
    Publication date: March 16, 2023
    Applicants: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, OXFORD NANOPORE TECHNOLOGIES PLC
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • Mutant pores
    Patent number: 11597970
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: March 7, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • Protein pores
    Patent number: 11572387
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: February 7, 2023
    Assignees: VIB VZW, Vrije Universiteit Brussel, Oxford Nanopore Technologies PLC
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • Modified helicases
    Patent number: 11525126
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: December 13, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • Modified helicases
    Patent number: 11525125
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: December 13, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Mark John Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • NOVEL PROTEIN PORES
    Publication number: 20220162264
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: March 18, 2021
    Publication date: May 26, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
  • MUTANT PORE
    Publication number: 20220154269
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
    Type: Application
    Filed: March 8, 2021
    Publication date: May 19, 2022
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • MODIFIED ENZYMES
    Publication number: 20220135956
    Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 13, 2021
    Publication date: May 5, 2022
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, Rebecca Victoria Bowen, Mark Bruce, Lakmal Jayasinghe, Joseph Hargreaves Lloyd, Szabolcs Soeroes, Elizabeth Jayne Wallace, Christopher Peter Youd
  • MUTANT PORE
    Publication number: 20220119879
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
    Type: Application
    Filed: October 26, 2021
    Publication date: April 21, 2022
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace