Abstract: Systems and methods for visual cue based messaging. A visual cue module can provide visual cue data indicative of a visual cue assigned for a contact or a group of contacts from a contact list. A messenger module can output on a display a messenger application GUI. The messenger application GUI includes a message field, a message window with a message thread between a user and the contact or the group of contacts, and a virtual keyboard. The messenger module can output the messenger application GUI with a visual cue graphical element representative of the visual cue to provide a visual indication of the contact or the group of contacts on the display to the user based on the visual cue data. The visual cue can be associated with the messaging field, the message thread, or at least one virtual key of the virtual keyboard.

Abstract: A system comprises quantum control interconnect circuitry configured to receive a plurality of fixed-frequency signals, a variable-frequency signal, a quantum control pulse, a quantum element readout pulse, and a quantum element return pulse. The circuitry is operable to upconvert the quantum control pulse using the fixed-frequency signals. The circuitry is operable to upconvert the readout pulse using the variable-frequency signal. The circuitry is operable to downconvert the return pulse using the variable-frequency signal.

Abstract: An embodiment for generating balanced train-test splits for machine learning analysis. The embodiment may automatically extract low-level features and high-level features from a series of received datasets. The embodiment may automatically determine a series of impactful features for each of the received datasets correlating to a corresponding label. The embodiment may automatically select subsets of impactful features The embodiment may automatically cluster the received datasets to generate series of clusters, each of the generated series of clusters corresponding to one of the selected subsets of impactful features. The embodiment may automatically generate train-test split versions using datasets from each cluster in each of the generated series of clusters. The embodiment may automatically score each of the generated train-test split versions and select a highest-scoring train-test split version.

Abstract: The present invention provides antibodies that bind to the T cell co-inhibitor lymphocyte activation gene 3 (LAG3) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that specifically bind to LAG3. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing LAG3 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection.

Abstract: Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: Devices and associated methods for containing and/or disposing of hydrocarbon fluids are disclosed herein. One aspect of the present technology, for example, includes a vessel formed of a plant-based absorbent substrate with an interior region configured to receive and retain a hydrocarbon fluid of at least 250 degrees Fahrenheit for at least 14 days without substantial deformation of the vessel or leaching of the hydrocarbon fluid.

Abstract: Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (CD) gene, in particular a humanization of a CD47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD47 gene so that said non-human animals express a CD47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion).

Abstract: A containerised modular electrochemical cell system, comprising: a housing; and a plurality of electrochemical stacks removably mounted within said housing, each stack comprising: one or more electrochemical cells; one or more fluid inlet(s) for receiving feedstock; and one or more product outlet(s), wherein the stacks are arranged in at least one string, each string comprising two or more of the stacks, the stacks in each string being electrically connectable in series, and each string being connectable to a power source, and wherein each stack or string is configured to be independently activated; and wherein each string comprises: at least one feedstock inlet manifold fluidly coupled to the inlet(s) of the stacks of the string for distributing feedstock between the inlet(s) of the stacks, and at least one product outlet manifold fluidly coupled to the outlet(s) of the stacks of the string; and flow regulation means configured to regulate fluid flow through the inlet(s) and/or outlet(s).

Abstract: A vehicle control device, including a main body, a vehicle control unit disposed within the main body to allow a user to control a vehicle, a vehicle power button disposed on at least a portion of the main body to allow the user to power on the vehicle from a distance, a trunk button disposed on at least a portion of the main body to allow the user to open a trunk of the vehicle from a distance, and a plurality of climate control buttons to allow the user to control an air conditioner or a heater of the vehicle from a distance.

Abstract: A composition comprising BL-8040 (SEQ ID NO: 1) is disclosed herein, which may be for use in treating a condition treatable by BL-8040. The composition further comprises at least one compound characterized by a relative retention time of from 0.86 to 0.88 and/or a relative retention time of from 0.71 to 0.73 (wherein a relative retention time of BL-8040 is 1) under conditions described herein.

Abstract: The invention generally discloses coronavirus vaccine for coronavirus disease. Particularly, the invention discloses coronavirus vaccine through nasal immunization. More particularly, the invention describes and develop a preventive vaccine against infection or disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through nasal immunization in mammals. Specifically, the invention describes human adenovirus which is engineered to express SARS-CoV-2 spike protein or part/fragment thereof which elicit immune response against the SARS-CoV-2 in mammals, and it is also suitable for immunizing human subjects. Describes the method of production of novel adenovirus vectors, use thereof in vaccine composition, vaccine formulation, preparation, and method of treatment of COVID-19 using above said novel vectors and compositions thereof.

Abstract: A system and method for machine learning architecture for prospective resource allocations are described. The method may include: receiving data records representing historical resource allocations from a user account associated with a first identifier to a resource account associated with a second identifier; deriving input features based on the data records; computing, using a trained neural network architecture, a predicted resource allocation amount and a predicted resource allocation date for the predicted resource allocation amount based on the derived input features; determining, using the trained neural network architecture, a first selection score associated with the predicted resource allocation amount and a second selection score associated with the predicted resource allocation date; and when the first or second selection score is above a minimum threshold, causing to display, at a display device, the associated resource allocation amount or date corresponding to the second identifier.

Abstract: Systems and methods for visual cue based messaging. A visual cue module can provide visual cue data indicative of a visual cue assigned for a contact or a group of contacts from a contact list. A messenger module can output on a display a messenger application GUI. The messenger application GUI includes a message field, a message window with a message thread between a user and the contact or the group of contacts, and a virtual keyboard. The messenger module can output the messenger application GUI with a visual cue graphical element representative of the visual cue to provide a visual indication of the contact or the group of contacts on the display to the user based on the visual cue data. The visual cue can be associated with the messaging field, the message thread, or at least one virtual key of the virtual keyboard.

Abstract: The technology described herein is directed to systems, methods, and software for indexing video. In an implementation, a method comprises identifying one or more regions of interest around target content in a frame of the video. Further, the method includes identifying, in a portion of the frame outside a region of interest, potentially empty regions adjacent to the region of interest. The method continues with identifying at least one empty region of the potentially empty regions that satisfies one or more criteria and classifying at least the one empty region as a negative sample of the target content. In some implementations, the negative sample of the target content in a set of negative samples of the target content, with which to train a machine learning model employed to identify instances of the target content.

Abstract: Provided are blocking agents to IL-1?, IL-1?, or IL-1R activity for use in combination with radiotherapy for treating cancer patients in which radiotherapy treatment induces IL-1?, IL-1? or both in their circulation.

Abstract: A system comprises quantum control interconnect circuitry configured to receive a plurality of fixed-frequency signals, a variable-frequency signal, a quantum control pulse, a quantum element readout pulse, and a quantum element return pulse. The circuitry is operable to upconvert the quantum control pulse using the fixed-frequency signals. The circuitry is operable to upconvert the readout pulse using the variable-frequency signal. The circuitry is operable to downconvert the return pulse using the variable-frequency signal.

Abstract: A bulk acoustic wave (BAW) device comprises a piezoelectric layer disposed between a first electrode layer and a sandwich electrode. The sandwich electrode includes a first layer of a first material having a first acoustic impedance and a second layer of a second material having a second acoustic impedance that is less than the first acoustic impedance of the first layer. The second layer of the sandwich electrode having the lower acoustic impedance is disposed between the first layer and the piezoelectric layer. The sandwich electrode combined with the piezoelectric layer and first electrode can cause the BAW device to resonate at a frequency whose wavelength corresponds to an acoustic cavity length of the BAW device, depending on an acoustic mirror included on one side of the BAW device. In one example, the acoustic cavity length is about 1.5 times of the resonant frequency wavelength.

Abstract: A composition comprising BL-8040 (SEQ ID NO: 1) is disclosed herein, which may be for use in treating a condition treatable by BL-8040. The composition further comprises at least one compound characterized by a relative retention time of from 0.86 to 0.88 and/or a relative retention time of from 0.71 to 0.73 (wherein a relative retention time of BL-8040 is 1) under conditions described herein.

Abstract: A composition of matter comprising a DNAzyme molecule capable of mediating cleavage of p21 mRNA corresponding to SEQ ID NO: 1, wherein said DNAzyme molecule comprises a nucleic acid sequence at least 80% identical to the nucleic acid sequence set forth in any one of SEQ ID NOs: 23, 29, 33-38, 40, 42, 45-48, 53-60, 63-65, 69-74 or 78, is disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: In one aspect, a reconfigurable apparatus includes a first configuration, where the first configuration of the reconfigurable apparatus serves as a packaging box for a backpack. Specifically, the backpack may be folded and inserted inside the reconfigurable apparatus with the first configuration. The reconfigurable apparatus also includes a second configuration, where the second configuration of the reconfigurable apparatus serves as a structure for the backpack. Specifically, the reconfigurable apparatus with the second configuration can be inserted inside the backpack to provide an internal structure for the backpack.