Patents by Inventor Ellen L. Berg
Ellen L. Berg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10240255Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.Type: GrantFiled: April 21, 2014Date of Patent: March 26, 2019Assignee: EUROFINS DISCOVERX CORPORATIONInventor: Ellen L. Berg
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Patent number: 10018621Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: June 13, 2013Date of Patent: July 10, 2018Assignee: Eurofins Discoverx CorporationInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20140315731Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.Type: ApplicationFiled: April 21, 2014Publication date: October 23, 2014Applicant: DISCOVERX CORPORATIONInventor: Ellen L. Berg
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Patent number: 8718945Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.Type: GrantFiled: March 28, 2008Date of Patent: May 6, 2014Assignee: DiscoveRx CorporationInventor: Ellen L. Berg
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Publication number: 20130266967Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: June 13, 2013Publication date: October 10, 2013Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 8467970Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: November 17, 2003Date of Patent: June 18, 2013Assignee: DiscoveRx CorporationInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 8019551Abstract: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.Type: GrantFiled: February 17, 2005Date of Patent: September 13, 2011Assignee: Bioseek LLCInventors: Elen S. Rosler, Eric J. Kunkel, Sylvie Privat, Jennifer Melrose, Melissa Fischer, Ellen L. Berg
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Patent number: 7912651Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: March 6, 2001Date of Patent: March 22, 2011Assignee: BioSeek LLCInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose, Ivan Plavec
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Patent number: 7908089Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: GrantFiled: May 27, 2004Date of Patent: March 15, 2011Assignee: BioSeek LLCInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20100235104Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.Type: ApplicationFiled: March 28, 2008Publication date: September 16, 2010Inventor: Ellen L. Berg
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Patent number: 7266458Abstract: The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence of the expressed product indicate that the expression product is involved with the pathway.Type: GrantFiled: September 5, 2002Date of Patent: September 4, 2007Assignee: Bioseek, Inc.Inventors: Ivan Plavec, Ellen L. Berg, Eugene C. Butcher
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Publication number: 20040219592Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: ApplicationFiled: May 27, 2004Publication date: November 4, 2004Applicant: BioSeek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20040157269Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: November 17, 2003Publication date: August 12, 2004Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 6763307Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: GrantFiled: September 13, 2001Date of Patent: July 13, 2004Assignee: BioSeek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20040063088Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: September 11, 2003Publication date: April 1, 2004Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose, Ivan Plavec
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Patent number: 6656695Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: March 6, 2001Date of Patent: December 2, 2003Assignee: Bioseek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20030138811Abstract: The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence of the expressed product indicate that the expression product is involved with the pathway.Type: ApplicationFiled: September 5, 2002Publication date: July 24, 2003Inventors: Ivan Plavec, Ellen L. Berg, Eugene C. Butcher
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Publication number: 20030133937Abstract: Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Lea and di-sialyl Lea, which are expressed at the surface of cancer cells, function as a binding partner for LEC-CAMs, such as ELAM-1, which are expressed at the surface of endothelial cells. The present invention also discloses that LEC-CAMs, such as ELAM-1, involved in cancer metastasis share a carbohydrate domain common to both sialyl Lea and sialyl Lex. Antibodies, saccharides, glycoconjugates, enzyme inhibitors and other compounds may be used in the methods of the present invention to inhibit the binding of malignant cells to endothelial cells for a variety of purposes in vivo and in vitro.Type: ApplicationFiled: October 10, 2002Publication date: July 17, 2003Applicant: John L. MagnaniInventors: John L. Magnani, Eugene C. Butcher, Ellen L. Berg
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Publication number: 20030113807Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: March 6, 2001Publication date: June 19, 2003Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20030017445Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: ApplicationFiled: September 13, 2001Publication date: January 23, 2003Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose