Patents by Inventor Ellen Ordinario

Ellen Ordinario has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DETECTION OF MALARIA
    Publication number: 20240102110
    Abstract: Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, oligonucleotide primers and oligonucleotide probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
    Type: Application
    Filed: December 3, 2021
    Publication date: March 28, 2024
    Inventors: Sharon Ho-Chen Chiu, Yvonne Gicheru, Marintha Heil, Michael K. Lee, Chitra Manohar, Rochak Mehta, Ellen Ordinario, Jaya Rajamani, Jingtao Sun
  • MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS
    Publication number: 20230121541
    Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
    Type: Application
    Filed: October 6, 2022
    Publication date: April 20, 2023
    Inventors: Ann Begovich, Cindy Cheung, Javelin Chi, Grantland Hillman, Dwight Kuo, Michael Lee, Chitra Manohar, Xiaoju Max Ma, Ellen Ordinario, Jaya Rajamani, Huan Truong
  • Multiplex PCR detection of ALK, RET, and ROS fusions
    Patent number: 11505830
    Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: November 22, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ann Begovich, Cindy Cheung, Javelin Chi, Grantland Hillman, Dwight Kuo, Michael Lee, Chitra Manohar, Xiaoju Max Ma, Ellen Ordinario, Jaya Rajamani, Huan Truong
  • Multiplex PCR to detect gene fusions
    Patent number: 10253349
    Abstract: Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ann Begovich, Rajiv Dua, Dwight Kuo, Xiaoju Max Ma, Ellen Ordinario
  • MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS
    Publication number: 20180346994
    Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Inventors: Ann Begovich, Cindy Cheung, Javelin Chi, Grantland Hillman, Dwight Kuo, Michael Lee, Chitra Manohar, Xiaoju Max Ma, Ellen Ordinario, Jaya Rajamani, Huan Truong
  • MULTIPLEX PCR TO DETECT GENE FUSIONS
    Publication number: 20160304937
    Abstract: Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.
    Type: Application
    Filed: April 15, 2016
    Publication date: October 20, 2016
    Inventors: Ann Begovich, Rajiv Dua, Dwight Kuo, Xiaoju Max Ma, Ellen Ordinario