Patents by Inventor Ellen S. Pizer

Ellen S. Pizer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100183507
    Abstract: The present invention features methods of diagnosing and prognosticating ovarian tumors by detecting increased expression of an ovarian tumor marker gene in a subject or in a sample from a subject. Also featured are kits for the aforementioned diagnostic and prognostic methods. In addition, the invention features methods of treating and preventing ovarian tumors, and methods of inhibiting the growth or metastasis of ovarian tumors, by modulating the production or activity of an ovarian tumor marker polypeptide. Further featured are methods of inhibiting the growth or metastasis of an ovarian tumor by contacting an ovarian tumor cell with an antibody that specifically binds an ovarian tumor marker polypeptide.
    Type: Application
    Filed: February 4, 2010
    Publication date: July 22, 2010
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human
    Inventors: Patrice J. Morin, Cheryl A. Sherman-Baust, Ellen S. Pizer, Colleen D. Hough
  • Publication number: 20080253963
    Abstract: The present invention features methods of diagnosing and prognosticating ovarian tumors by detecting increased expression of an ovarian tumor marker gene in a subject or in a sample from a subject. Also featured are kits for the aforementioned diagnostic and prognostic methods. In addition, the invention features methods of treating and preventing ovarian tumors, and methods of inhibiting the growth or metastasis of ovarian tumors, by modulating the production or activity of an ovarian tumor marker polypeptide. Further featured are methods of inhibiting the growth or metastasis of an ovarian tumor by contacting an ovarian tumor cell with an antibody that specifically binds an ovarian tumor marker polypeptide.
    Type: Application
    Filed: August 24, 2007
    Publication date: October 16, 2008
    Inventors: Patrice J. Morin, Cheryl A. Sherman-Baust, Ellen S. Pizer, Colleen D. Hough
  • Patent number: 7279294
    Abstract: The present invention features methods of diagnosing and prognosticating ovarian tumors by detecting increased expression of an ovarian tumor marker gene in a subject or in a sample from a subject. Also featured are kits for the aforementioned diagnostic and prognostic methods. In addition, the invention features methods of treating and preventing ovarian tumors, and methods of inhibiting the growth or metastasis of ovarian tumors, by modulating the production or activity of an ovarian tumor marker polypeptide. Further featured are methods of inhibiting the growth or metastasis of an ovarian tumor by contacting an ovarian tumor cell with an antibody that specifically binds an ovarian tumor marker polypeptide.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: October 9, 2007
    Assignee: The United States of America as represented by the Secretary, Dept. of Health and Human Services, NIH
    Inventors: Patrice J. Morin, Cheryl A. Sherman-Baust, Ellen S. Pizer, Colleen D. Hough
  • Publication number: 20030211498
    Abstract: The present invention features methods of diagnosing and prognosticating ovarian tumors by detecting increased expression of an ovarian tumor marker gene in a subject or in a sample from a subject. Also featured are kits for the aforementioned diagnostic and prognostic methods. In addition, the invention features methods of treating and preventing ovarian tumors, and methods of inhibiting the growth or metastasis of ovarian tumors, by modulating the production or activity of an ovarian tumor marker polypeptide. Further featured are methods of inhibiting the growth or metastasis of an ovarian tumor by contacting an ovarian tumor cell with an antibody that specifically binds an ovarian tumor marker polypeptide.
    Type: Application
    Filed: October 3, 2002
    Publication date: November 13, 2003
    Inventors: Patrice J Morin, Cheryl A Sherman-Baust, Ellen S Pizer, Colleen D Hough
  • Publication number: 20020187534
    Abstract: This invention describes a method to kill cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism tht does not involve inhibition of FAS. Alternatively, growth of tumor cells may be induced by a combination of effects including FAS inhibition in conjunction with other interventions which affect fatty acid metabolism, including inhibition of carnitine palmitoyltransferase-1 (CPT-1). Any combination of drugs which produces an analogous physiologic effect(s) may be expected to lead to the same effect on susceptible tumor cells. For example, combination therapy with drug(s) that inhibit the fatty acid synthesis by inhibiting acetyl CoA carboxylase (the first enzyme in the fatty acid synthesis pathway) and drug(s) that inhibit CPT-1 may be expected to induce apoptosis in tumor cells.
    Type: Application
    Filed: May 10, 2002
    Publication date: December 12, 2002
    Inventors: Ellen S. Pizer, Craig A. Townsend, Francis P. Kuhajda