Abstract: Poly(amidoamine) [PAMAM] dendrimers for use as PSMA-targeted contrast agents for optical and photoacoustic imaging (PA) and theranostic agents for treating prostate cancer are disclosed.

Abstract: The disclosed systems and methods are directed for detecting and resolving write-write conflicts among a plurality of transactions received from master nodes of a multi-writer database system. The method includes receiving a plurality of REDO logs and storing the plurality of REDO logs in a buffer, each REDO log associated with the one of the plurality of transactions, selecting one REDO log of the plurality of REDO logs; persisting the transaction associated with the one REDO log in a local storage when a write-write conflict is detected between the one REDO log and at least one other REDO log of the plurality of REDO logs prior to committing the transaction associated with the one REDO log; and transmitting a status of the transaction associated with the one REDO log to a global transaction manager (GTM).

Abstract: Ultrasound is typically performed with the use of an external transcutaneous probe that emits ultrasonic energy and measures the timing of reflected waves, thus allowing measurement of fluid flow or formation of a two-dimensional image. Clinically, the modality is limited by attenuation of the signal with increasing depth of penetration of the ultrasound into tissues, as well as by similarities in echo-genicity between different tissues. The present invention includes a system in which an intravascular probe actively transmits ultrasound that can then be detected by in-line piezoelectric transducers without reflection. This signal can be overlaid onto traditional B-mode or Doppler representation. Furthermore, the present invention includes a signal processing system that will display a real-time graphical representation of the vascular anatomy in order to assist the surgeon or procedural radiologist in the placement of central venous catheters.

Abstract: A method and system for implementing concurrency control in a database system includes receiving a request from a node for handling by a GTM. Registering the request in a slot in a tracking array where each of the slots represents one of the requests for handling by the GTM. A slot is acquired, and a segment of the tracking array is scanned to determine a batch of pending requests. The batch is used to produce an aggregate request and the aggregate request includes an aggregate increment of a total number of commit requests of the batch. The aggregate request is sent to the GTM using one of a plurality of pre-established connections. A response is received from the GTM that includes a current value of an incremented timestamp. The incremented timestamp is distributed to the requests of the batch and the lock is released.

Abstract: Photoacoustic voltage dependent dyes and their use in measuring an electrophysiological activity in a subject in vivo are disclosed.

Abstract: The disclosed systems and methods are directed for detecting and resolving write-write conflicts among a plurality of transactions received from master nodes of a multi-writer database system. The method includes receiving a plurality of REDO logs and storing the plurality of REDO logs in a buffer, each REDO log associated with the one of the plurality of transactions, selecting one REDO log of the plurality of REDO logs; persisting the transaction associated with the one REDO log in a local storage when a write-write conflict is detected between the one REDO log and at least one other REDO log of the plurality of REDO logs prior to committing the transaction associated with the one REDO log; and transmitting a status of the transaction associated with the one REDO log to a global transaction manager (GTM).

Abstract: An embodiment in accordance with the present invention provides a precise catheter tracking system, Active Ultrasound Pattern Injection System (AUSPIS). AUSPIS establishes ultrasonic communication between any ultrasound external probe and internal catheter (CUTE catheter). The system receives image beacon pulses, analyzes the acquired signal, and fires one or a series of active echo pulses from the same active echo element with a proper timing, frequency, duration and amplitude. Thus it enables injection of any “virtual” pattern into the B-mode image. The pattern injected to the B-mode image is from actively encoded ultrasound field in the tissue. The encoding is based on B-mode ultrasound image formation technique, so it doesn't require hardware or software modification to the US machine. It continuously measures the local acoustic signal amplitude, by which sub-millimeter elevation localization accuracy can be achieved.

Abstract: An underwater imaging system is disclosed. A boat sonar transducer is configured to transmit and receive sonar signals and generate an image of water and surfaces using received sonar signals. An active echo system is configured to be positioned within the water to remotely communicate with the boat sonar transducer. The active echo system includes an ultrasound transducer configured to detect sonar signals transmitted by the boat sonar transducer and transmit an active echo pulse, or a series of active echo pulses, back to the boat sonar transducer. A microprocessor is configured to drive the ultrasound transducer to transmit the active echo pulse, or series of active echo pulses, back to the boat sonar transducer in response to the ultrasound transducer detecting sonar signals transmitted by the boat sonar transducer.

Abstract: The present invention is directed to a method and system for photoacoustic imaging for guiding medical procedures. A transducer is placed near the site of the procedure. The optical fiber, coupled to an electromagnetic source, such as a laser, is attached to a medical device. During the procedure, the device and optical fiber are inserted into the procedure site where the optical fiber illuminates the procedure site, which has a thickness of approximately 2 mm. Photoacoustic images are acquired to visualize the procedure site as the procedure is proceeding in order to provide real-time guidance. This system is applicable to multiple surgical and interventional procedures, such as transsphenoidal surgery.

Abstract: Ultrasound is typically performed with the use of an external transcutaneous probe that emits ultrasonic energy and measures the timing of reflected waves, thus allowing measurement of fluid flow or formation of a two-dimensional image. Clinically, the modality is limited by attenuation of the signal with increasing depth of penetration of the ultrasound into tissues, as well as by similarities in echo-genicity between different tissues. The present invention includes a system in which an intravascular probe actively transmits ultrasound that can then be detected by in-line piezoelectric transducers without reflection. This signal can be overlaid onto traditional B-mode or Doppler representation. Furthermore, the present invention includes a signal processing system that will display a real-time graphical representation of the vascular anatomy in order to assist the surgeon or procedural radiologist in the placement of central venous catheters.

Abstract: Imaging of internal structure of a patient, such as the prostate, is performed using ultrasound tomography by inserting a first ultrasound probe into the rectum of the patient, positioning a second ultrasound probe on an abdomen of the patient, and aligning the first and second ultrasound probes with one another to obtain acoustic information for reconstructing tomographic images of the internal structure. Light sources can also be shined to the tissue of interest, such as prostate say by a transurethral catheter thus making photoacoustic waves that can be received by the said TRUS or TRAB/TRPR transducers to reconstruct photoacoustic tomographic image of the tissue, as well.

Abstract: Photoacoustic voltage dependent dyes and their use in measuring an electrophysiological activity in a subject in vivo are disclosed.

Abstract: An embodiment in accordance with the present invention provides a precise catheter tracking system, Active Ultrasound Pattern Injection System (AUSPIS). AUSPIS establishes ultrasonic communication between any ultrasound external probe and internal catheter (CUTE catheter). The system receives image beacon pulses, analyzes the acquired signal, and fires one or a series of active echo pulses from the same active echo element with a proper timing, frequency, duration and amplitude. Thus it enables injection of any “virtual” pattern into the B-mode image. The pattern injected to the B-mode image is from actively encoded ultrasound field in the tissue. The encoding is based on B-mode ultrasound image formation technique, so it doesn't require hardware or software modification to the US machine. It continuously measures the local acoustic signal amplitude, by which sub-millimeter elevation localization accuracy can be achieved.

Abstract: Systems and methods for real-time tracking of photoacoustic sensing are provided. In one aspect, a method for performing in vivo analysis of a subject is provided. The method includes directing an electromagnetic excitation toward a subject to be analyzed, and acquiring, with an ultrasound probe, data about resultant waves caused by the electromagnetic excitation. The method also includes processing the acquired data to extract information related to properties of tissues in the subject, and comparing the information related to the properties of tissues in the subject using a set of criteria. The method also includes generating a report about a condition of the subject based on the comparison of the information related to properties of the tissues in the subject.

Abstract: A system and method for improved ultrasound strain imaging includes using data from a tracking system to enhance the quality of ultrasound strain image and to reduce the dependency of image quality of the user's expertise. The tracking information is synchronized with the RF frames and interpolated to find the transformation corresponding to each frame. The RF frames with their transformations are incorporated into calculation of ultrasound strain images. The tracking system may be an optical tracker, electromagnetic tracker, accelerometer, or a structured light system. The structured light system may also be used for probe calibration, by calibrating the surface of the probe pre-operatively. In addition, a relative Young's Modulus may be calculated using tracking information that is independent from the distribution of input force.

Abstract: An underwater imaging system is disclosed. A boat sonar transducer is configured to transmit and receive sonar signals and generate an image of water and surfaces using received sonar signals. An active echo system is configured to be positioned within the water to remotely communicate with the boat sonar transducer. The active echo system includes an ultrasound transducer configured to detect sonar signals transmitted by the boat sonar transducer and transmit an active echo pulse, or a series of active echo pulses, back to the boat sonar transducer. A microprocessor is configured to drive the ultrasound transducer to transmit the active echo pulse, or series of active echo pulses, back to the boat sonar transducer in response to the ultrasound transducer detecting sonar signals transmitted by the boat sonar transducer.

Abstract: Ultrasound is typically performed with the use of an external transcutaneous probe that emits ultrasonic energy and measures the timing of reflected waves, thus allowing measurement of fluid flow or formation of a two-dimensional image. Clinically, the modality is limited by attenuation of the signal with increasing depth of penetration of the ultrasound into tissues, as well as by similarities in echo-genicity between different tissues. The present invention includes a system in which an intravascular probe actively transmits ultrasound that can then be detected by in-line piezoelectric transducers without reflection. This signal can be overlaid onto traditional B-mode or Doppler representation. Furthermore, the present invention includes a signal processing system that will display a real-time graphical representation of the vascular anatomy in order to assist the surgeon or procedural radiologist in the placement of central venous catheters.

Abstract: The present invention is directed to a method and system for photoacoustic imaging for guiding medical procedures. A transducer is placed near the site of the procedure. The optical fiber, coupled to an electromagnetic source, such as a laser, is attached to a medical device. During the procedure, the device and optical fiber are inserted into the procedure site where the optical fiber illuminates the procedure site, which has a thickness of approximately 2 mm. Photoacoustic images are acquired to visualize the procedure site as the procedure is proceeding in order to provide real-time guidance. This system is applicable to multiple surgical and interventional procedures, such as transsphenoidal surgery.

Abstract: Systems and methods for real-time tracking of photoacoustic sensing are provided. In one aspect, a method for performing in vivo analysis of a subject is provided. The method includes directing an electromagnetic excitation toward a subject to be analyzed, and acquiring, with an ultrasound probe, data about resultant waves caused by the electromagnetic excitation. The method also includes processing the acquired data to extract information related to properties of tissues in the subject, and comparing the information related to the properties of tissues in the subject using a set of criteria. The method also includes generating a report about a condition of the subject based on the comparison of the information related to properties of the tissues in the subject.

Abstract: An interventional photoacoustic imaging system and method for cancer treatment comprises an optical source for applying laser energy to optically excite a treatment area, a needle, ablation tool or catheter for inserting the optical source into a body of a patient adjacent the treatment area, and an ultrasonic transducer for detecting the acoustic waves. A processor receives the raw data from the ultrasound system and processes it to thereby form a photoacoustic image of the tissue in real time. As such, image formation may be performed preoperatively, intraoperatively, and postoperatively.