Patents by Inventor Emad Sarofim
Emad Sarofim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9638612Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.Type: GrantFiled: April 25, 2014Date of Patent: May 2, 2017Assignee: Roche Molecular Systems, Inc.Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
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Publication number: 20170100715Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.Type: ApplicationFiled: December 20, 2016Publication date: April 13, 2017Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
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Patent number: 9606140Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.Type: GrantFiled: May 23, 2014Date of Patent: March 28, 2017Assignee: Roche Diagnostics Operations, Inc.Inventors: Geza Burghardt, Michael Glauser, Oliver Gutmann, Daniel Mueller, Edwin Oosterbroek, Roger Sandoz, Emad Sarofim, Goran Savatic
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Patent number: 9557269Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.Type: GrantFiled: April 2, 2014Date of Patent: January 31, 2017Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
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Publication number: 20160367176Abstract: A system for withdrawing blood from a body part that avoids formation of a drop of blood on the skin surface of the body part after blood removal. The system includes a collecting unit to withdraw blood, a lancing member configured for insertion into the body part and having a capillary to collect blood, and a pressure piece configured to apply pressure to the body part and having an actuator operably connected thereto. The pressure piece is movable relative to a support configured to exert pressure on the body part, and the actuator is configured to reduce the compressive force of the pressure piece after removing an amount of blood, whereby forming a drop of blood on the skin surface of the body part can be avoided.Type: ApplicationFiled: July 22, 2016Publication date: December 22, 2016Inventors: Stephan Korner, Rainer Jaeggi, Patrick Griss, Emad Sarofim, Irio Giuseppe Calasso
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Publication number: 20160303556Abstract: A pressure transmission liquid for a cellular analyzer, a cellular analyzer, and a method for analyzing a liquid cellular sample using such a cellular analyzer are disclosed. The pressure transmission liquid comprises an aqueous solution of at least one substance, wherein the solution has isotonic and substantially non-conductive characteristics. The cellular analyzer comprises a pipetting module having a pipetting tip, an automated positioning device for positioning the pipetting module, a capacitive liquid level sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid reservoir comprising such a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.Type: ApplicationFiled: April 15, 2016Publication date: October 20, 2016Inventors: Martin Kopp, Emad Sarofim
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Patent number: 9414774Abstract: A system and method for carrying out the withdrawal of body fluid with as little body fluid as possible visible to the user at the end of the process. The present invention provides a pressure piece for exerting pressure on a body part. The pressure piece is moved relative to a support for the body part, and in the final phase of fluid withdrawal, the compressive or resistive force of the pressure piece on the body part is reduced in order to avoid the escape of body fluid from the puncture site. The support results in a defined positioning of the body part that rests against it for the lancing process, whereas the relative movement of the pressure piece enables an additional increase in pressure and thus an improved collection of fluid.Type: GrantFiled: October 9, 2006Date of Patent: August 16, 2016Assignee: Roche Diabetes Care, Inc.Inventors: Stephan Korner, Rainer Jaeggi, Patrick Griss, Emad Sarofim, Irio Guiseppe Calasso
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Patent number: 9316656Abstract: The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.Type: GrantFiled: November 12, 2009Date of Patent: April 19, 2016Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Emad Sarofim, Lotar Schenk, Hans-Peter Wahl
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Patent number: 9063038Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: GrantFiled: March 13, 2013Date of Patent: June 23, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Patrick Griss, Stephan Korner, Emad Sarofim
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Patent number: 9022952Abstract: Body fluid sampling device comprising a skin-piercing element having a fluid pathway for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.Type: GrantFiled: March 15, 2012Date of Patent: May 5, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Irio Guiseppe Calasso, Patrick Griss, Rainer Jaeggi, Emad Sarofim
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Patent number: 8961901Abstract: A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.Type: GrantFiled: July 26, 2007Date of Patent: February 24, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Michael Glauser, Hans-Peter Wahl, Irio Giuseppe Calasso, Emad Sarofim
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Publication number: 20150017681Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.Type: ApplicationFiled: July 8, 2014Publication date: January 15, 2015Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
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Publication number: 20140360269Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.Type: ApplicationFiled: May 23, 2014Publication date: December 11, 2014Applicant: Roche Diagnostics Operations, In.cInventors: Geza Burghardt, Michael Glauser, Oliver Gutmann, Daniel Mueller, Edwin Oosterbroek, Roger Sandoz, Emad Sarofim, Goran Savatic
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Publication number: 20140329249Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.Type: ApplicationFiled: April 25, 2014Publication date: November 6, 2014Applicant: Roche Molecular Systems, Inc.Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
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Patent number: 8814808Abstract: Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 ?m. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.Type: GrantFiled: September 10, 2010Date of Patent: August 26, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Irio Guiseppe Calasso, Patrick Griss, Emad Sarofim, Rainer Jaeggi, Uwe Kraemer, Dave Hasker, Volker Zimmer, Wilifried Schmid, Otto Fuerst, Hans List, Hans-Peter Haar, Theo Arnitz, Steven N. Roe
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Patent number: 8808648Abstract: The invention refers to a disposable sample holding and processing device (1) for being used in an apparatus for analyzing a liquid sample by nucleic acid amplification, especially polymerase chain reaction technique, comprising a device body (2) having a structured surface and a sealing cover (4) which covers the structured surface thereby forming a wall of an amplification chamber (5)), which amplification chamber (5) is designed and intended for performing nucleic acid amplification for analyzing the liquid sample, and a wall of an inlet channel (6) connected to the amplification chamber (5) for providing the amplification chamber (5) with liquid. According to the invention the device body (2) comprises a sheet (20) on which the structured surface forming the inlet channel (6) is arranged, and that the sheet (20) carries at least one rib (34, 35, 36) for increasing the stiffness of the device body (2).Type: GrantFiled: July 5, 2007Date of Patent: August 19, 2014Assignee: Roche Molecular Systems, Inc.Inventor: Emad Sarofim
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Patent number: 8808647Abstract: Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.Type: GrantFiled: September 10, 2009Date of Patent: August 19, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudio Cherubini, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
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Publication number: 20140220669Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.Type: ApplicationFiled: April 2, 2014Publication date: August 7, 2014Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
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Patent number: 8797526Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.Type: GrantFiled: November 14, 2011Date of Patent: August 5, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
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Patent number: 8778696Abstract: A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.Type: GrantFiled: August 5, 2010Date of Patent: July 15, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Oliver Gutmann, Edwin Oosterbroek, Michael Glauser, Michael Andreas Heinrich, Jean-Pierre Bolliger, Emad Sarofim, Rainer D. Jaeggi