Patents by Inventor Emil R. Unanue

Emil R. Unanue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR AND METHODS OF DIAGNOSING, PROGNOSING, AND TREATING DIABETES
    Publication number: 20210018520
    Abstract: Among the various aspects of the present disclosure is the provision of compositions for and methods of diagnosing, prognosing, and treating diabetes.
    Type: Application
    Filed: July 15, 2020
    Publication date: January 21, 2021
    Applicant: Washington University
    Inventors: Emil R. Unanue, Xiaoxiao Wan, Cheryl Lichti
  • MODULATING AUTOIMMUNE DIABETES BY REDUCING OR REMOVING THE RESIDENT MACROPHAGES OF THE ISLETS OF LANGERHANS
    Publication number: 20190248909
    Abstract: The present disclosure provides methods of selectively depleting islet macrophages in the pancreas comprising disrupting the CSF-1 pathway.
    Type: Application
    Filed: February 13, 2019
    Publication date: August 15, 2019
    Inventors: Emil R. Unanue, Javier A. Carrero
  • TREATMENT OF DIABETES MELLITUS, METHODS AND COMPOSITIONS THEREFOR
    Publication number: 20160215054
    Abstract: Methods of treatment of diabetes are disclosed. These methods include administration of an inhibitor of chemokine XCL1, and administration of an inhibitor of XCL1 receptor XCR1. Inhibition of formation of CD103+ dendritic cells, inhibition of their migration into islets, or inhibition of function of CD103+ dendritic cells can be used to prevent, treat or manage diabetes.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 28, 2016
    Applicant: Washington University
    Inventors: Emil R. Unanue, Kenneth M. Murphy, Javier A. Carrero
  • Method of enhancing peptide immunogenicity
    Patent number: 5021551
    Abstract: A method is disclosed for enhancement of the immunogenicity of a T cell immunogenic peptide which comprises adding an acidic amino acid at the N-terminus and/or a positive charge at the C-terminus of said peptide.
    Type: Grant
    Filed: January 18, 1989
    Date of Patent: June 4, 1991
    Assignee: Washington University
    Inventors: Paul M. Allen, Emil R. Unanue