Abstract: A laser system suitable for modification of a calcified blood vessel includes a laser source; a feedback controller configured to regulate a dosimetry of the laser source to produce spatially and/or temporally modulated laser light; a catheter comprising a first optical delivery element, the first optical delivery element configured to guide the modulated laser light to an in-vivo object in the blood vessel; and a detecting element, configured to detect one or more physical, chemical, mechanical and/or dimensional characteristics of an area of the in-vivo object in real-time, wherein the feedback controller is configured to process the real-time detected information pertaining to the one or more physical, chemical, mechanical and/or dimensional characteristics of the area in real-time, wherein the feedback controller is further configured to regulate the dosimetry of the laser source for a controlled formation of a porous structure and/or a zone of denaturized tissue in the in-vivo object.

Abstract: A laser system for changing an IOP of an eye includes a laser source; a feedback controller, configured to regulate a dosimetry of the laser source to produce spatially and/or temporally modulated laser light; a first optical delivery element, configured to guide the spatially and/or temporally modulated laser light to irradiate a first area on the eye; and a detecting element, configured to detect one or more physical, chemical, mechanical and/or structural characteristics in a second area on the eye in a real-time during the change of the IOP, wherein the feedback controller is configured to regulate the dosimetry of the laser source in a real-time based on the real-time detected information pertaining to the one or more physical, chemical, mechanical and/or structural characteristics in the second area.

Abstract: A laser system suitable for a treatment of a cartilage tissue in a joint includes a laser source; a feedback controller, configured to regulate a dosimetry of the laser source to produce spatially and/or temporally modulated laser light; a first optical delivery element, configured to guide the spatially and/or temporally modulated laser light to an area in the joint to irradiate a first part of the area; and a detecting element, configured to detect one or more physical, chemical, mechanical and/or structural characteristics in the area in a real-time; wherein the feedback controller is configured to regulate in a real-time the dosimetry of the laser source based on the real-time detected information pertaining to the one or more physical, chemical, mechanical and/or structural characteristics in the area for a controlled activation of a stem cell outside of the first part of the area to form a hyaline cartilage tissue.

Abstract: A device and associated method for treatment of tissue in a joint of a mammal includes an energy source and an energy-delivery implement coupled to the energy source. The energy-delivery implement has a distal portion configured to be inserted into the joint, the distal portion having at least one energy-emitting portion. A control module causes the energy source to produce energy in a pre-defined treatment sequence, the sequence comprising at least two pulses of energy separated by an interval. The energy-delivery implement is configured to emit the energy at the distal portion, to create a zone of thermal stress within target tissue, without causing substantial coagulation of the target tissue, wherein the size of the thermal stress zone is substantially less than the size of the target tissue being treated. A biologic can be injected or otherwise delivered into the joint before, during, or after delivery of the energy.

Abstract: The invention relates to a method and apparatus for opto-thermo-mechanical treatment of biological tissue.