Abstract: Systems and methods of selectively routing a packet flow are provided. In one exemplary embodiment, a method is performed by a first network node associated with a first network and operable to selectively route packet flows between the first network and a second network over first and second access nodes associated with corresponding first and second access networks. The method includes contemporaneously routing both a first packet flow through the first access node and a second packet flow through the second access node based on a network metric associated with the first or second access network, a user or device activity preference associated with the first network and a user or device activity associated with the first or second packet flow. Further, each access networks is operable to enable the first network node to access the second network over the corresponding access node.

Abstract: Systems and methods of selectively routing a packet flow are provided. In one exemplary embodiment, a method is performed by a first network node associated with a first network and operable to selectively route packet flows between the first network and a second network over first and second access nodes associated with corresponding first and second access networks. The method includes contemporaneously routing both a first packet flow through the first access node and a second packet flow through the second access node based on a network metric associated with the first or second access network, a user or device activity preference associated with the first network and a user or device activity associated with the first or second packet flow. Further, each access networks is operable to enable the first network node to access the second network over the corresponding access node.

Abstract: A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

Abstract: A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

Abstract: A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

Abstract: The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. A bridging liquid is added to the slurry in at least two stages and solids within the slurry are agitated to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate. The bridging liquid may be added in an area of relatively high shear rates. Between stages of bridging liquid addition, agglomerates may be removed.

Abstract: Described is a method of processing a bituminous feed. The bituminous feed is solvent extracted to form a bitumen-rich stream and a bitumen-lean stream. Solvent is recovered from the bitumen-rich stream to form a bitumen product. Solvent and water are recovered from the bitumen-lean stream to form dry tailings with a moisture content of less than 40 wt.%. The dry tailings are separated into at least two streams, each stream having a moisture content of less than 40 wt. %, based on at least one physical or chemical property. At least one of the at least two streams is then used at an oil sands mine site. In this way, the dry tailings may be used more effectively.

Abstract: Described herein is a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. A bridging liquid is added to the slurry, and, solids are agitated within the slurry to form an agglomerated slurry comprising agglomerates and a low solids bitumen extract. In order to control agglomeration, the slurry is analyzed and the processing method is adjusted accordingly.

Abstract: The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. The slurry is then flowed through a pipeline. A bridging liquid is added to the slurry to assist agglomeration. Agitation is also used to assist agglomeration. The result is an agglomerated slurry comprising agglomerates and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Performing the agglomeration in a pipeline as opposed to in a conventional agitating vessel may provide certain advantages, such as improved sealing in order to contain the potentially flammable mixture of oil sands slurry from the atmosphere, production of smaller and more uniform agglomerates due to improved mixing of the bridging liquid into the oil sands slurry, and the flexibility to have a long residence time for the extraction and agglomeration processes.

Abstract: The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with a bridging liquid-in-extraction liquor emulsion to form a slurry. Solids in the slurry are agglomerated, using agitation, to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Emulsifying the bridging liquid prior to contacting it with the oil sands may reduce the amount of energy required for the agglomeration process. Other potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate.

Abstract: A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 represents a group selected from: i) phenyl optionally substituted with one or two substituents independently selected from Me, OMe, CF3, F, Cl and NMe2; furanyl, thiophenyl, pyrrolyl, pyridyl, cyclohexyl or naphthyl, each of which is optionally substituted with one or two substituents independently selected from Me, OMe, CF3, F, Cl and NMe2; and iii) benzo[1,3]dioxo5-yl or 2,3-dihydrobenzo[1,4]dioxin-6-yl; R2 represents CF3, C1-4alkyl, or CHF2; when R1 represents optionally substituted furanyl, thiophenyl, pyrrolyl, pyridyl or naphthyl, R3 represents Et; when R1 represents optionally substituted cyclohexyl, R3 represents Et or Me; otherwise R3 represents Et, Me, Br or OMe, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided, together with certain novel compounds.

Abstract: Systems and methods for hydrotreating a liquid fraction of a shale oil stream using hydrogen gas that is concentrated from a gaseous fraction of the shale oil stream. The systems and methods include providing a portion of the gaseous fraction to a sorptive separation assembly and separating a concentrated hydrogen stream from the portion of the gaseous fraction within the sorptive separation assembly. The system and methods further include providing the concentrated hydrogen stream and the liquid fraction to a hydrotreater and reacting the concentrated hydrogen stream with the liquid fraction within the hydrotreater to produce the hydrotreated liquid stream. The systems and methods may include generating the shale oil stream within a subterranean formation using an in situ process, such as an in situ shale oil conversion process and/or providing a supplemental hydrogen stream to the hydrotreater.

Abstract: Processes are described for extracting hydrocarbon from a mineable deposit, such as bitumen from oil sands. The integration of solvent-based extraction processes with aqueous extraction processes is described. In one embodiment, water is removed from an aqueous bituminous feed that is then directed into a solvent-based extraction process. In another embodiment, a stream produced through solvent extraction is directed into a water-based extraction process. In the solvent-based extraction processes, agglomeration of fines may be employed to simplify subsequent solid-liquid separation. The process permits recovery of hydrocarbon that has conventionally may have been too difficult to recover from oil sands processing, and thus has previously been lost. Advantageously, a fungible product can be formed more efficiently according to certain integrated processes described herein.

Abstract: Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the antibiotic. The invention is exemplified with improved production of penicillin in Penicillium chrysogenum, with the isolation of another clustered biosynthetic gene(s) and with the expression of penicillin biosynthetic genes in Acremonium chrysogenum.