Abstract: Functional, brain region-specific neural spheroids comprising neuronal cells and optionally glial cells at varying ratios are disclosed, as are methods of making such spheroids and methods for their use, such as for modeling particular brain regions that may be implicated in diseases, or for observing drug effects.

Abstract: Methods and apparatuses are described for determining future user actions using time-based featurization of clickstream data. A server captures clickstream data corresponding to web browsing sessions and converts the clickstream data into tokens by identifying each unique URL and parsing each unique URL into tokens. The server generates a frequency matrix based upon the tokens, and generates a latent feature vector for each URL in the session based upon the frequency matrix. The server merges the latent feature vectors and the clickstream data into an aggregate clickstream vector set for a user. The server assigns time-decayed weight values to each latent feature vector in the aggregate clickstream vector set. The server combines the time-decayed latent feature vectors to generate a clickstream embedding for the user, and executes a machine learning model using the clickstream embedding to generate one or more predicted actions of the user.