Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: The disclosure describes embodiments of systems, methods, and non-transitory computer readable storage media that utilize a machine learning model and a credit value model to generate user interface elements that present credit values and credit value conditions in real time for user accounts. For instance, the disclosed systems can generate an activity score using an activity machine learning model with internal user activity data of a user account. Then, utilizing a credit value model with the activity score and a user activity condition, the disclosed systems can determine a dynamic credit value range for the user account. Indeed, the disclosed systems can display user interface elements with selectable credit values from the dynamic credit value range. Additionally, the disclosed systems can utilize the credit value model to determine and display one or more dynamic credit value conditions for a selected credit value received from the selectable credit values.

Abstract: An electronic device may include an antenna and a coaxial cable coupled to the antenna. The coaxial cable may have a signal conductor coupled to an antenna resonating element of the antenna and a ground conductor coupled to an antenna ground of the antenna. The ground conductor may include an ungrounded segment that is separated from the antenna ground by a gap. A capacitive coupling between the ground conductor in the ungrounded segment and the antenna ground via the gap may form an impedance matching component for the coaxial cable. A dielectric retention layer may overlap the coaxial cable and hold the coaxial cable in place relative to the antenna ground to maintain the gap.

Abstract: A computer system is configured to receiving a data set from a data provider and automatically save the data set in a quarantine database where copying, moving, and sharing of the data set are restricted until the data set is released by a data provider. The data set is parsed to find and mark portions with potentially sensitive information. At least those parts are reviewed by a data governor, who can confirm, add, edit, or remove markers. Those parts can be visually indicated to the data governor, along with a preview of, metadata about, and analysis of the data set. After reviewing at least the automatically marked portions, the data governor can release the data set to a non-quarantine database where another user can use the data set. The user is restricted from accessing the quarantine database.

Abstract: A system and method can provide charter-based access to resources using an object model. Charters are defined by an administrator to have certain markings, each marking indicating a control (e.g., permission, credential, qualification, constraint, requirement, etc.) that regulates work under the charter. Users are also associated with markings. A user starts a session to access the system and is authenticated. The system determines charters having markings that the user has, and these charters are provided to the user to select from. Selecting a charter allows the user access to resources associated with the charter, under the controls indicated by the markings. Charters, controls, qualifications, resources, authorizations and links between them can be implemented using an object model. Markings can control session parameters (e.g.

Abstract: A system and method can provide charter-based access to resources using an object model. Charters are defined by an administrator to have certain markings, each marking indicating a control (e.g., permission, credential, qualification, constraint, requirement, etc.) that regulates work under the charter. Users are also associated with markings. A user starts a session to access the system and is authenticated. The system determines charters having markings that the user has, and these charters are provided to the user to select from. Selecting a charter allows the user access to resources associated with the charter, under the controls indicated by the markings. Charters, controls, qualifications, resources, authorizations and links between them can be implemented using an object model. Markings can control session parameters (e.g.

Abstract: In one embodiment, a method includes accessing from a client system associated with a first user sensor signals captured by sensors of the client system, wherein the client system comprises a plurality of sensors, and wherein the sensors signals are accessed from the sensors based on cascading model policies, wherein each cascading model policy utilizes one or more of a respective cost or relevance associated with each sensor, detecting a change in a context of the first user associated with an activity of the first user based on machine-learning models and the sensor signals, wherein the change in the context of the first user satisfies a trigger condition associated with the activity, and responsive to the detected change in the context of the first user automatically capturing visual data by cameras of the client system.

Abstract: A computer system is configured to receiving a data set from a data provider and automatically save the data set in a quarantine database where copying, moving, and sharing of the data set are restricted until the data set is released by a data provider. The data set is parsed to find and mark portions with potentially sensitive information. At least those parts are reviewed by a data governor, who can confirm, add, edit, or remove markers. Those parts can be visually indicated to the data governor, along with a preview of, metadata about, and analysis of the data set. After reviewing at least the automatically marked portions, the data governor can release the data set to a non-quarantine database where another user can use the data set. The user is restricted from accessing the quarantine database.

Abstract: A computer system is configured to receiving a data set from a data provider and automatically save the data set in a quarantine database where copying, moving, and sharing of the data set are restricted until the data set is released by a data provider. The data set is parsed to find and mark portions with potentially sensitive information. At least those parts are reviewed by a data governor, who can confirm, add, edit, or remove markers. Those parts can be visually indicated to the data governor, along with a preview of, metadata about, and analysis of the data set. After reviewing at least the automatically marked portions, the data governor can release the data set to a non-quarantine database where another user can use the data set. The user is restricted from accessing the quarantine database.

Abstract: A system and method can provide charter-based access to resources using an object model. Charters are defined by an administrator to have certain markings, each marking indicating a control (e.g., permission, credential, qualification, constraint, requirement, etc.) that regulates work under the charter. Users are also associated with markings. A user starts a session to access the system and is authenticated. The system determines charters having markings that the user has, and these charters are provided to the user to select from. Selecting a charter allows the user access to resources associated with the charter, under the controls indicated by the markings. Charters, controls, qualifications, resources, authorizations and links between them can be implemented using an object model. Markings can control session parameters (e.g.

Abstract: Provided are methods of treating breast cancer in a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of miR-105 or an inhibitor of miR-122 are provided. Also provided herein are methods of determining a level of miR-105 or a level of miR-122 in a subject that has or is at risk for developing breast cancer. The method includes obtaining a biological sample from the subject and determining a level of miR-105 or a level of miR-122 or a combination thereof in the biological sample, wherein a higher level of miR-105 or miR-122 as compared to a control indicates that the subject has or is at risk of developing breast cancer.

Abstract: A method for providing on-demand service information is provided. One or more processors determine, for a given geographic region, position information for each of a plurality of requesters for an on-demand service and position information for each of a plurality of service providers that can provide the on-demand service. A plurality of sub-regions is identified for the given geographic region. Based, at least in part, on the position information of the requesters and the service providers, one or more sub-regions are determined as being under-supplied by the plurality of service providers as compared to one or more other sub-regions. Information identifying the under-supplied sub-regions are provided to one or more service provider devices.

Abstract: Areas of non-conformances in a manufactured object are electronically mapped within a coordinate system of the object. Boundary lines of the areas containing the non-conformances are displayed on a 3-D image of the product. Visualization of the boundary lines of areas containing multiple non-conformances allows tracking of non-conformances, identification of trends in non-conformances and correction of production processes in order to reduce non-conformances.

Abstract: A method for providing on-demand service information is provided. One or more processors determine, for a given geographic region, position information for each of a plurality of requesters for an on-demand service and position information for each of a plurality of service providers that can provide the on-demand service. A plurality of sub-regions is identified for the given geographic region. Based, at least in part, on the position information of the requesters and the service providers, one or more sub-regions are determined as being under-supplied by the plurality of service providers as compared to one or more other sub-regions. Information identifying the under-supplied sub-regions are provided to one or more service provider devices.

Abstract: A method for providing on-demand service information is provided. One or more processors determine, for a given geographic region, position information for each of a plurality of requesters for an on-demand service and position information for each of a plurality of service providers that can provide the on-demand service. A plurality of sub-regions is identified for the given geographic region. Based, at least in part, on the position information of the requesters and the service providers, one or more sub-regions are determined as being under-supplied by the plurality of service providers as compared to one or more other sub-regions. Information identifying the under-supplied sub-regions are provided to one or more service provider devices.

Abstract: A method for providing on-demand service information is provided. One or more processors determine, for a given geographic region, position information for each of a plurality of requesters for an on-demand service and position information for each of a plurality of service providers that can provide the on-demand service. A plurality of sub-regions is identified for the given geographic region. Based, at least in part, on the position information of the requesters and the service providers, one or more sub-regions are determined as being under-supplied by the plurality of service providers as compared to one or more other sub-regions. Information identifying the under-supplied sub-regions are provided to one or more service provider devices.

Abstract: A method for providing on-demand service information is provided. One or more processors determine, for a given geographic region, position information for each of a plurality of requesters for an on-demand service and position information for each of a plurality of service providers that can provide the on-demand service. A plurality of sub-regions is identified for the given geographic region. Based, at least in part, on the position information of the requesters and the service providers, one or more sub-regions are determined as being under-supplied by the plurality of service providers as compared to one or more other sub-regions. Information identifying the under-supplied sub-regions are provided to one or more service provider devices.

Abstract: Areas of non-conformances in a manufactured object are electronically mapped within a coordinate system of the object. Boundary lines of the areas containing the non-conformances are displayed on a 3-D image of the product. Visualization of the boundary lines of areas containing multiple non-conformances allows tracking of non-conformances, identification of trends in non-conformances and correction of production processes in order to reduce non-conformances.

Abstract: A high frequency surface wave radar (HFSWR) system with improved performance. Two or more transmitters including separate transmitting antennas (120, 122, 410) are used to improve the performance of the HFSWR over the performance of a comparable system with a single transmitter. In one embodiment, two transmitters are used, and configured to transmit pulses alternately, with a time interval of at least a round-trip travel time corresponding to a maximum target range between any pair of transmitted pulses. A physical receiving antenna array (130) includes a plurality of receiving antenna elements (135), and is connected to receiver circuitry configured to distinguish returns corresponding to pulses emitted by the different transmitters. The returns are concatenated in the receiver circuitry to achieve improved resolution.

Abstract: Various embodiments are described herein for a detector and method that perform various types of CFAR detection on radar data including knowledge-aided CFAR detection, hybrid-CFAR detection and simplified censored CFAR detection. Knowledge about the type of local environment of a Cell Under Test and the proximity of the Cell Under Test to various types of noise can be used to select particular types of CFAR detection methods or combinations thereof. In other instances, certain parameters of a CFAR detection method can be adapted based on this knowledge.