Abstract: The invention provides a multispecific molecule capable of simultaneous binding to a Mucosal Associated Invariant T (MAIT) cell and a tumor cell, which multispecific molecule comprises at least one domain that specifically binds a V?7.2 T cell receptor (TCR) and at least one domain that specifically binds a tumor associated antigen (TAA).

Abstract: An apparatus for studying aerosol includes a test chamber having panels defining an enclosed interior volume. The panels have (i) a first wall having a surface defining an interior of the test chamber, (ii) a second wall defining an exterior of the test chamber, (iii) a void space between the first and second walls, (iv) a panel inlet in communication with the void space, and (v) a panel outlet in communication with the void space. The apparatus includes a chamber inlet port and a chamber outlet port, each extending through one of the panels and in communication with the enclosed interior volume. The apparatus includes a fan disposed in, and positioned and configured to mix air in, the enclosed interior volume. The apparatus includes a trap port extending through one of panels and includes a valve to permit sampling of the contents in the enclosed interior volume.

Abstract: The present invention relates to a pharmaceutical combination for inducing one or more immune responses and/or for enhancing effectiveness of vaccination in the host, which is capable of inducing cross-protection against multiples strains and/or serotypes of a virus. In one embodiment, the pharmaceutical combination is able to generate protection in food producing animals, such as cattle, sheep, goats, swine and other cloven-hoofed animals with fewer vaccination campaigns.

Abstract: The present invention relates to a pharmaceutical combination for inducing one or more immune responses and/or for enhancing effectiveness of vaccination in the host, which is capable of inducing cross-protection against multiples strains and/or serotypes of a virus. In one embodiment, the pharmaceutical combination is able to generate protection in food producing animals, such as cattle, sheep, goats, swine and other cloven-hoofed animals with fewer vaccination campaigns.

Abstract: Steaming accessory (4) including a receptacle (5) for collecting condensates designed to rest on a mixing bowl of a household appliance having a means of heating the contents of the mixing bowl, the receptacle (5) having a cavity (50) for collecting condensates and two gripping handles (52). The cavity (50) having a bottom with a protruding shaft (53) equipped with a central orifice allowing steam to pass through the accessory (4) also having at least one basket (6) for cooking food that is positioned on the receptacle (5), in which the shaft (53) includes, near its upper end, an annular wall extending around the central orifice and crosswise to the shaft (53), and in that the shaft (53) includes a deflecting wall that stands taller than the level of the annular wall.

Abstract: The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules. In one embodiment, the present invention provides a method to quantify and characterize size and integrity of Foot and Mouth Disease virus (FMDV) using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present invention further comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate FMDV containing products for preventing Foot and Mouth Disease (FMD). In one embodiment, the methods described herein assess the stability of FMDV. In another embodiment, the methods described herein serve as in-process quality control for a manufacturing process of FMD vaccine.

Abstract: The present disclosure relates to bispecific antibodies targeting EGFR and HER2, and methods for the production of these antibodies. The bispecific antibodies consist of one complete antibody on which two VH-VL chains are attached via a linker to each NH terminal region of both VH chains of the antibody. The bispecific antibodies constructed use the amino acid sequences of the heavy chain (VH) and the light chain (VL) variable regions of two monoclonal antibodies targeting EGFR and HER2, namely cetuximab and trastuzumab, respectively.

Abstract: The present invention relates to a pharmaceutical combination for inducing one or more immune responses and/or for enhancing effectiveness of vaccination in the host, which is capable of inducing cross-protection against multiples strains and/or serotypes of a virus. In one embodiment, the pharmaceutical combination is able to generate protection in food producing animals, such as cattle, sheep, goats, swine and other cloven-hoofed animals with fewer vaccination campaigns.

Abstract: The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules. In one embodiment, the present invention provides a method to quantify and characterize size and integrity of Foot and Mouth Disease virus (FMDV) using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present invention further comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate FMDV containing products for preventing Foot and Mouth Disease (FMD). In one embodiment, the methods described herein assess the stability of FMDV. In another embodiment, the methods described herein serve as in-process quality control for a manufacturing process of FMD vaccine.

Abstract: The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present method quantifies and characterizes the size and integrity of enveloped or non-enveloped virus, live or live-attenuated or inactivated virus, recombinant viral vectors, or virus-like particles (VLPs). In one embodiment, the present invention comprises a column-switching system for running multiple analyzes simultaneously. The present invention also provides a method to develop and evaluate virus containing products for the prevention of viral diseases. In another embodiment, the methods described herein serve as in-process quality control for manufacturing processes of virus vaccines.

Abstract: An electrical food preparation appliance includes a working container enclosing a tool rotated by a motor, a device for heating the contents of the working container and a removable lid that covers the working container, the lid having an opening for inserting ingredients into the working container, at least one steam exhaust orifice, and a removable measuring cap accommodated into said opening for inserting ingredients. The measuring cap can occupy at least two stable positions in the opening of the lid and in that the motion of the measuring cap from one stable position to the other makes it possible to vary the passage cross-section of the steam exhaust orifice.

Abstract: The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present method quantifies and characterizes the size and integrity of enveloped or non-enveloped virus, live or live-attenuated or inactivated virus, recombinant viral vectors, or virus-like particles (VLPs). In one embodiment, the present invention comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate virus containing products for the prevention of viral diseases. In another embodiment, the methods described herein serve as in-process quality control for manufacturing processes of virus vaccines.

Abstract: Steaming accessory (4) including a receptacle (5) for collecting condensates designed to rest on a mixing bowl of a household appliance including a means of heating the contents of the mixing bowl, the receptacle (5) having a cavity (50) for collecting condensates and two gripping handles (52) arranged symmetrically on either side of the cavity (50), said cavity (50) having a bottom including a protruding shaft (53) equipped with a central orifice allowing steam to pass through, said accessory (4) also having at least one basket (6) for cooking food that is positioned on said receptacle (5), wherein the shaft (53) includes, near its upper end, an annular wall extending around the central orifice and crosswise to the shaft (53), and wherein the shaft (53) includes, facing each gripping handle (52), a deflecting wall that stands taller than the level of the annular wall.

Abstract: A polymeric vehicle window is described, having a composite component with an inner opaque polymeric layer and an outer transparent polymeric layer, wherein the inner opaque polymeric layer and the outer transparent polymeric layer are connected in a planar manner. The inner opaque polymeric layer has at least one at least partially piercing hole, an LED assembly, with an LED, a printed circuit board, and electrical contacts arranged in the hole. The LED assembly is placed in such a way that the LED is in the direction of the outer transparent assembly.

Abstract: Household electrical appliance control panel (6) comprising a membrane (7) with blisters (70) defining the keys of the control panel (6) and a backing piece (8) to which the membrane (7) is attached, the backing piece (8) having openings (80) opposite said blisters (70), wherein the membrane (7) and the backing piece (8) are respectively made of a first and a second chemically non-metallizable material and wherein the backing piece (8) comprises at least one part that is not covered by the membrane (7) and onto which a decorative piece (9) of chemically metallizable material is overmoulded, the decorative piece (9) having an external surface which is chemically metallized.

Abstract: The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules. In one embodiment, the present invention provides a method to quantify and characterize size and integrity of Foot and Mouth Disease virus (FMDV) using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present invention further comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate FMDV containing products for preventing Foot and Mouth Disease (FMD). In one embodiment, the methods described herein assess the stability of FMDV. In another embodiment, the methods described herein serve as in-process quality control for a manufacturing process of FMD vaccine.

Abstract: An electrical food preparation appliance includes a working container enclosing a tool rotated by a motor, a device for heating the contents of the working container and a removable lid that covers the working container, the lid having an opening for inserting ingredients into the working container, at least one steam exhaust orifice, and a removable measuring cap accommodated into said opening for inserting ingredients. The measuring cap can occupy at least two stable positions in the opening of the lid and in that the motion of the measuring cap from one stable position to the other makes it possible to vary the passage cross-section of the steam exhaust orifice.

Abstract: A polymeric vehicle window is described, having a composite component with an inner opaque polymeric layer and an outer transparent polymeric layer, wherein the inner opaque polymeric layer and the outer transparent polymeric layer are connected in a planar manner. The inner opaque polymeric layer has at least one at least partially piercing hole, an LED assembly, with an LED, a printed circuit board, and electrical contacts arranged in the hole. The LED assembly is placed in such a way that the LED is in the direction of the outer transparent assembly.