Patents by Inventor Emmanuel S. Antonarakis

Emmanuel S. Antonarakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
    Patent number: 11866787
    Abstract: Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: January 9, 2024
    Assignee: The Johns Hopkins University
    Inventors: Jun Luo, Emmanuel S. Antonarakis, Changxue Lu
  • Methods and compositions related to prostate cancer therapeutics
    Patent number: 11345956
    Abstract: Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective therapeutic regimens for prostate cancer patients. Disclosed herein are methods of using biological molecules and biomarkers related to androgen-receptor splice variants for assessing therapeutic resistance to drugs such as enzalutamide and abiraterone.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: May 31, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun Luo, Emmanuel S. Antonarakis, Changxue Lu, William Isaacs
  • Methods For Identifying Androgen Receptor Splice Variants In Subjects Having Castration Resistant Prostate Cancer
    Publication number: 20210032706
    Abstract: Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.
    Type: Application
    Filed: September 11, 2020
    Publication date: February 4, 2021
    Inventors: Jun Luo, Emmanuel S. Antonarakis, Changxue Lu
  • METHODS AND COMPOSITIONS RELATED TO PROSTATE CANCER THERAPEUTICS
    Publication number: 20170275673
    Abstract: Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective therapeutic regimens for prostate cancer patients. Disclosed herein are methods of using biological molecules and biomarkers related to androgen-receptor splice variants for assessing therapeutic resistance to drugs such as enzalutamide and abiraterone.
    Type: Application
    Filed: August 25, 2015
    Publication date: September 28, 2017
    Inventors: Jun Luo, Emmanuel S. Antonarakis, Changxue Lu, Willian Isaacs