Patents by Inventor Enrico Anthony Antonini

Enrico Anthony Antonini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Industrial method for separation and purification of fentanyl by reverse phase preparative chromatography
    Patent number: 7728145
    Abstract: There is described a process for the purification of an impure preparation containing fentanyl by means of a reverse phase preparative chromatography process. A chromatographic column is loaded with a stationary phase, typically a silica particle having an organic ligand bound thereto. With a loading ratio of from about 50 to about 150 the impure preparation is acidified and passed through the column. The column is eluted with typically an aqueous solution of acetonitrile and the purified fentanyl is obtained in a specified cut.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: June 1, 2010
    Assignee: Mallinckrodt Inc.
    Inventor: Enrico Anthony Antonini
  • Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
    Patent number: 7671203
    Abstract: An apparatus and method for separating at least one narcotic alkaloid that includes loading a stationary phase media into a high performance preparative liquid chromatography column, feeding a crude narcotic alkaloid solution into the chromatographic column, applying a mobile phase to the chromatographic column, and recovering a narcotic alkaloid eluate from the chromatographic column. The narcotic eluates arc collected and treated separately from each other. Each separated alkaloid, however, has sufficient recovery and purity.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: March 2, 2010
    Assignee: Mallinckrodt Inc.
    Inventor: Enrico Anthony Antonini