Patents by Inventor Enrique Luis Michelotti
Enrique Luis Michelotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7741479Abstract: The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.Type: GrantFiled: December 7, 2005Date of Patent: June 22, 2010Assignee: Locus Pharmaceuticals, Inc.Inventors: Enrique Luis Michelotti, Eric Bruce Springman, Duyan Nguyen, Rupa S. Shetty, Younghee Lee, Kristofer Kent Moffett, Jennifer Lee Ludington, Ted Tsutomis Fujimoto, Zenon D. Konteatis, Bin Liu, Frank Hollinger, Bruce D. Dorsey
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Publication number: 20100041642Abstract: Urea containing compounds that inhibit MAP kinases, pharmaceutical compositions including such compounds and methods for using these compounds to treat inflammatory diseases and cancer are described herein.Type: ApplicationFiled: August 15, 2009Publication date: February 18, 2010Applicant: LOCUS PHARMACEUTICALS, INC.Inventors: Duyan NGUYEN, Martha KELLY, Kristofer MOFFETT, Enrique Luis MICHELOTTI, Bin Liu
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Patent number: 7612200Abstract: The present invention is directed to a compound having the formula wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.Type: GrantFiled: December 7, 2005Date of Patent: November 3, 2009Assignee: Locus Pharmaceuticals, Inc.Inventors: Enrique Luis Michelotti, William R. Moore, Jr., Eric Bruce Springman
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Publication number: 20090192307Abstract: The present invention is directed to a compound having the formula wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.Type: ApplicationFiled: December 7, 2005Publication date: July 30, 2009Inventors: Enrique Luis Michelotti, William R. Moore, JR., Eric Bruce Springman
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Patent number: 6566403Abstract: This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.Type: GrantFiled: June 16, 1997Date of Patent: May 20, 2003Assignee: Dow AgroSciences LLCInventors: Enrique Luis Michelotti, David Hamilton Young, Thomas Anthony McLaughlin
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Patent number: 6353020Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: July 13, 2000Date of Patent: March 5, 2002Assignee: Dow AgroSciences LLCInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6319936Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: July 13, 2000Date of Patent: November 20, 2001Assignee: Dow AgroSciences LLCInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6140362Abstract: A method for inhibiting mammalian cell growth is disclosed. The method uses compounds known as N-acetonylarylamides. The compounds have been shown to inhibit cell mitosis and to inhibit microtubule assembly. The method may be used to treat diseases associated with rapid cell growth, particularly cancer. The compounds used in the method of the present invention may be used in combination with other therapies and may be administered by known techniques for drug administration.Type: GrantFiled: September 29, 1997Date of Patent: October 31, 2000Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, David Hamilton Young
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Patent number: 6107340Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: November 4, 1999Date of Patent: August 22, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6107316Abstract: A method for treating protozoal infections is described. The method employs N-acetonylbenzamide compounds provided in an effective amount to inhibit the growth of protozoans. The compounds are useful in controlling such protozoan parasites as Giardia lamblia, Leishmania major, Entamoeba histolytica, Cryptosporidium parvum, Toxoplasma gondii and microsporidia.Type: GrantFiled: April 29, 1998Date of Patent: August 22, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Enrique Luis Michelotti, Thomas David Edlind, Santosh Kumar Katiyar
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Patent number: 6075047Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: November 4, 1999Date of Patent: June 13, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6069171Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: November 4, 1999Date of Patent: May 30, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6060490Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: November 4, 1999Date of Patent: May 9, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6057365Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound which is [2-methyl-1-[1-(4-methylphenyl)-ethylaminocarbonyl]-propyl]-carbamic acid, isopropyl ester to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: December 22, 1998Date of Patent: May 2, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6057356Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: November 4, 1999Date of Patent: May 2, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6011065Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: September 4, 1998Date of Patent: January 4, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 6004947Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: September 4, 1998Date of Patent: December 21, 1999Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
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Patent number: 5981435Abstract: A method for controlling algae and marine fouling organisms is described. The method employs N-acetonylbenzamides compounds provided in an effective amount to kill or inhibit the growth of the algae or fouling organisms.Type: GrantFiled: May 14, 1998Date of Patent: November 9, 1999Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, David Hamilton Young
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Patent number: 5969200Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.Type: GrantFiled: October 22, 1998Date of Patent: October 19, 1999Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski
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Patent number: 5945565Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.Type: GrantFiled: October 22, 1998Date of Patent: August 31, 1999Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski