Patents by Inventor Enzo PORRELLO

Enzo PORRELLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cardiomyocyte maturation
    Patent number: 11920158
    Abstract: A cardiomyocyte maturation medium comprises a base medium, one or more fatty acids such as palmitic acid, glucose and albumin. The one or more fatty acids and glucose are ideally present at a concentration ratio of about 1:10. Typically, the medium does not comprise TGF or insulin, or comprises minimal TGF and/or insulin. A cell culture vessel is provided that comprises opposed poles that facilitate force measurements of developing cardiac muscle.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: March 5, 2024
    Assignee: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
    Inventors: Enzo Porrello, James Hudson, Drew Titmarsh, Richard Mills
  • CARDIOMYOCYTE PROLIFERATION
    Publication number: 20220187282
    Abstract: Provided herein are in vitro and in vivo methods of inducing cardiomyocyte proliferation by contacting cardiomyocytes with or administering to a subject an effective amount of an agent capable of activating sterol biosynthesis, such as mevalonate biosynthesis. Methods and compositions for regenerating a cardiac tissue in a subject that include administering thereto a therapeutically effective amount of an agent capable of activating sterol biosynthesis in a cardiomyocyte are also provided herein.
    Type: Application
    Filed: March 18, 2019
    Publication date: June 16, 2022
    Inventors: James HUDSON, Richard MILLS, Enzo PORRELLO, Gregory QUAIFE-RYAN
  • CARDIOMYOCYTE MATURATION
    Publication number: 20190203179
    Abstract: A cardiomyocyte maturation medium comprises a base medium, one or more fatty acids such as palmitic acid, glucose and albumin. The one or more fatty acids and glucose are ideally present at a concentration ratio of about 1:10. Typically, the medium does not comprise TGF or insulin, or comprises minimal TGF and/or insulin. A cell culture vessel is provided that comprises opposed poles that facilitate force measurements of developing cardiac muscle.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 4, 2019
    Inventors: Enzo PORRELLO, James HUDSON, Drew TITMARSH, Richard MILLS