Abstract: The present disclosure provides a toilet spray apparatus which operates automatically, removing the need for a user to take any actions to reduce or eliminate toilet odours, and which requires no batteries to operate, instead taking advantage of the pressure resulting from a user sitting on a toilet seat. In response to a user sitting, the apparatus will emit a vaporised spray of fluid into a toilet bowl forming a protective layer that prevents unpleasant odours from rising. The apparatus comprises a reservoir body, a spring-operated pump mechanism, an extended outlet for hooking over a toilet bowl rim, and a housing.

Abstract: A toothbrush (10) includes a brush assembly (16) with at least three bristle arrangements (12), each having opposing inwardly-directed bristles (122, 124, 126) for simultaneously contacting facial and lingual surfaces (52, 54), and preferably also occlusal surfaces (56) of the teeth (50). Flexible linkages (14), interconnecting the bristle arrangements (12), maintain a relative spacing between the bristle arrangements (12) while allowing variation of an effective curvature of the brush assembly (16) such that the bristle arrangements (12) can ride along, and conform to a non-uniform curvature of, the arch of teeth. The toothbrush (IO) preferably also includes an actuation mechanism (22) for generating to-and-fro motion of the brush assembly (16) along the arch of teeth, most preferably combined with a more rapid small-amplitude oscillatory motion.

Abstract: A toothbrush (10) includes a brush assembly (16) with at least three bristle arrangements (12), each having opposing inwardly-directed bristles (122, 124, 126) for simultaneously contacting facial and lingual surfaces (52, 54), and preferably also occlusal surfaces (56) of the teeth (50). Flexible linkages (14), interconnecting the bristle arrangements (12), maintain a relative spacing between the bristle arrangements (12) while allowing variation of an effective curvature of the brush assembly (16) such that the bristle arrangements (12) can ride along, and conform to a non-uniform curvature of, the arch of teeth. The toothbrush (TO) preferably also includes an actuation mechanism (22) for generating to-and-fro motion of the brush assembly (16) along the arch of teeth, most preferably combined with a more rapid small-amplitude oscillatory motion.

Abstract: A method of determining predicting putative contacting sites of a target protein is disclosed. The method uses a substitution matrix for calculating contact probabilities for pairs of columns in a sequence alignment containing the amino acid sequence of the target protein. The contact probabilities can also be used for predicting the three-dimensional structure of the protein. The putative contacts and/or three-dimensional structure typically correspond to the hydrophobic core of the target protein.