Abstract: The application discloses a particle for chemiresistor sensor. The particle may include: a nanoparticle core made from a conductive material selected from a group consisting of: Ir, Ir-alloy, IrOx, Ru, Ru-alloy, RuOx and any combination thereof and/or any conducting metallic oxide, having a cross section size of at most 100 nm; and a plurality of organic ligands bonded from one side to the nanoparticle core and capable of interacting with a volatile organic compound.

Abstract: The present invention provides methods for profiling the microbiome of a subject from a sample obtained from the subject using a Scent Reader/Recorder which detects and records the scent in the headspace of the sample and generates a pattern of sensor signals that can be analyzed using machine learning techniques. The invention further provides methods for detecting changes in the microbiome profile of a subject, and methods for providing health and nutritional recommendations to subjects.

Abstract: Disclosed is a method of determining a condition of a subject based on Volatile Organic Compounds (VOCs) in a gaseous phase, originating from the subject. The method may include: receiving from one or more sensors a set of sensor signals in response to exposing the one or more sensors to a sample of the VOCs; extracting one or more feature values from the set of sensor signals; receiving a classification model, trained to classify samples of VOCs based on the one or more extracted feature values correlated to one or more condition of the subject; associating the one or more extracted features received from the set of sensor signals with one or more classes of the classification model; and determining the condition of the subject based on the association.

Abstract: The present invention relates to compositions and methods of treating multiple sclerosis. Particularly, the present invention relates to pharmaceutical compositions comprising antibodies having affinity to both fibroblast growth factor receptor 2 (FGFR2) and FGFR3 for use in treating multiple sclerosis.

Abstract: Optimizing read operations to a storage device in a virtualized computing environment. A read system call is received by a virtual machine's (VM) operating system from an application running on the VM for data on a storage device. The VM is hosted by a hypervisor providing access to the storage device in a virtualized computing environment. A virtual file system (VFS) supported by the operating system is caused to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute the read operation. In response to determining by the PVS FE that the data to be read exists in a data cache of the PVFS FE, executing by the PVS FE the read operation from the cache of the PVFS FE.

Abstract: The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof.

Abstract: The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof.

Abstract: A method of and system for managing storage of an object for an object store is disclosed. The method and system may establish the object store. The object store may be configured to be used for a user for a workload-type for a set of objects. The method and system may provide, for the user for the workload-type, an object store quota. The method and system may provide, for the user for the workload-type, a meta-data quota. The method and system may process, consistent with both the object store quota and the meta-data quota, the set of objects.

Abstract: Optimizing read operations to a storage device in a virtualized computing environment. A read system call is received by a virtual machine's (VM) operating system from an application running on the VM for data on a storage device. The VM is hosted by a hypervisor providing access to the storage device in a virtualized computing environment. A virtual file system (VFS) supported by the operating system is caused to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute the read operation. In response to determining by the PVS FE that the data to be read exists in a data cache of the PVFS FE, executing by the PVS FE the read operation from the cache of the PVFS FE.

Abstract: Machines, systems and methods of uploading data files, the method comprising a first client machine dividing a first file into N data chunks to be uploaded to a server, wherein the N data chunks are of size kX, where k is an integer and X is size of a minimal size data chunk, wherein X is known by the server and by at least a second client machine used for uploading a second file to the server in data chunks of size k?X; and uploading the first file to the server, wherein a first unique signature is calculated for the first file based on applying a signature function to a collection of signatures calculated for the minimal size data chunks of size X that make up the data chunks of size kX in the first file, wherein the uploading of the first file is accomplished by uploading the data chunks of size kX to the server in any order.

Abstract: Systems and methods for optimizing write operations to a storage device in a virtualized computing environment comprise monitoring write operations issued by an application running on a virtual machine's (VM) operating system, wherein the VM is hosted by a hypervisor providing access to a storage device in a virtualized computing environment; and causing a virtual file system (VFS) supported by the operating system to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute a write operation, in response to determining that the write operation is to write data to the storage device, wherein data that is to be written to the storage device is first written to a VM memory area allocated to the VM and accessible to the hypervisor hosting the VM.

Abstract: The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.

Abstract: The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof.

Abstract: A method of and system for managing storage of an object for an object store is disclosed. The method and system may establish the object store. The object store may be configured to be used for a user for a workload-type for a set of objects. The method and system may provide, for the user for the workload-type, an object store quota. The method and system may provide, for the user for the workload-type, a meta-data quota. The method and system may process, consistent with both the object store quota and the meta-data quota, the set of objects.

Abstract: Machines, systems and methods of uploading data files, the method comprising a first client machine dividing a first file into N data chunks to be uploaded to a server, wherein the N data chunks are of size kX, where k is an integer and X is size of a minimal size data chunk, wherein X is known by the server and by at least a second client machine used for uploading a second file to the server in data chunks of size k?X; and uploading the first file to the server, wherein a first unique signature is calculated for the first file based on applying a signature function to a collection of signatures calculated for the minimal size data chunks of size X that make up the data chunks of size kX in the first file, wherein the uploading of the first file is accomplished by uploading the data chunks of size kX to the server in any order.

Abstract: The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides that include a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions of the same and methods for use thereof.

Abstract: Systems and methods for associating a first process with a first state and a first computing environment initialized according to a first set of parameters, wherein a first task is to be performed under a first security context. The method further comprising associating a second process with a second state and a second computing environment initialized according to a second set of parameters; in response to the first process submitting a first request, the second process spawning a third process which has the second state; wherein the third process sets a security context for the third process to the first security context and the third process sets the computing environment for the third process according to a first a set of parameters; executing the third process under the first security context and in association with the second state; and executing the first task in the first computing environment.

Abstract: Systems and methods for optimizing read operations from a storage device in a virtualized computing environment are provided. One method comprises monitoring read operations issued by an application running on a virtual machine's (VM) operating system, wherein the VM is hosted by a hypervisor providing access to a storage device in a virtualized computing environment; and causing a virtual file system (VFS) supported by the operating system to call on a first para-virtualized file system (PVFS FE) supported by the operating system to execute a read operation, in response to determining that the read operation is for reading target data from the storage device.

Abstract: Molecules comprising the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.

Abstract: In accordance with one or more embodiments, an inode implemented file system may be utilized to support both offline and inline deduplication. When the first content is stored in the storage medium, one inode is used to associate a filename with the data blocks where the first content is stored. When a second content that is a duplicate of the first content is to be stored, then a parent inode is created to point to the data blocks in which a copy of the first content is stored. Further, two inodes are created, one representing the first content and the other representing the second content. Both inodes point to the same parent inode that points to the data blocks where the first content is stored.