Patents by Inventor Erez Bublil

Erez Bublil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20240091325
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: August 23, 2023
    Publication date: March 21, 2024
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11771745
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: October 3, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20230042914
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 28, 2022
    Publication date: February 9, 2023
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20220265835
    Abstract: The present disclosure provides formulations for a drug product comprising a PEGylated CBS protein having the amino acid sequence of SEQ ID NO: 1. Dosages and dosing regimens are provided for treatment of homocystinuria in a subject in need thereof. Additionally, the dosages and dosing regimens are also provided to reduce the level of homocysteine (Hcy) or increase the levels of cysteine (Cys) and/or cystathionine (Cth) in a subject in need thereof.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 25, 2022
    Inventors: Erez Bublil, Frank Glavin, Marcia Sellos-Moura, Jan P. Kraus, Tomas Majtan, Randy Wanner, Orhan Causevic
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11400143
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20220125896
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 29, 2021
    Publication date: April 28, 2022
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11077175
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: August 3, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20200316179
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 8, 2020
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20200276282
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 3, 2020
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 10729753
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 10653755
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: May 19, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
    Patent number: 10624959
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: April 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20190125845
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 2, 2019
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 10265387
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: April 23, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20180318404
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: November 9, 2016
    Publication date: November 8, 2018
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • CHEMICALLY MODIFIED CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20180311325
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Application
    Filed: July 2, 2018
    Publication date: November 1, 2018
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Chemically modified cystathionine ?-synthase enzyme for treatment of homocystinuria
    Patent number: 10046036
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 14, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20170224787
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: April 20, 2017
    Publication date: August 10, 2017
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 9675678
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: June 13, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P Kraus, Tomas Majtan, Erez Bublil
  • CHEMICALLY MODIFIED CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20170065687
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Application
    Filed: August 12, 2016
    Publication date: March 9, 2017
    Inventors: Jan P KRAUS, Tomas MAJTAN, Erez BUBLIL