Abstract: A modular switch and a method that includes (a) first tier switching elements that comprise input output (IO) ports; and (b) second tier switching elements that are coupled to the first tier switching elements in a non-blocking manner. The first tier switching elements are configured to perform traffic management of traffic, and perform substantially all egress processing and ingress processing of the traffic; wherein the traffic management comprises load balancing, traffic shaping and flow-based reordering. The second tier switching elements are configured to (a) provide a shared memory space to the first tier switching elements, (b) perform substantially all of the queuing of traffic and (c) send, to the first tier switching elements, status information related to the status of shared memory resources. The first tier switching elements are configured to perform the traffic management based, at least in part, on the status information.

Abstract: The invention is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

Abstract: According to one aspect, systems and methods are provided that intelligently automate payment routing. According to various embodiments, the intelligent routing can be augmented with machine learning models that generate an optimal routing of a transaction, wherein for example, the optimal routing can be based on a unique set of circumstances for each transaction. In further embodiments, machine learning models accept payment processing information and circumstance (e.g., payment modality, store location, online payment location, source IP address, payor IP address, merchant IP address, physical presence, intermediary information, merchant information, payment brand, supplier data, among a host of other options) and based on the trained model can generate an optimal path for any particular transaction.

Abstract: The disclosure is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

Abstract: The disclosure is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

Abstract: Disclosed herein are topical formulations comprising about 0.001 to about 3 wt % detomidine or a salt thereof; and, a carrier that is suitable for topical administration to a subjects skin, wherein the carrier comprises hydrophilic and hydrophobic phase members in specified ratios, and wherein the detomidine is fully dissolved and chemically stable in the hydrophilic phase member. The topical formulations may be provided in the form of emulsions, creams, ointments, gels, spray patches, dispersions, and other specified forms. Also provided are methods for providing prolonged, non-systemic treatment for pain in a subject in need thereof comprising topically administering to the subject the presently disclosed topical formulations.

Abstract: The disclosure is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

Abstract: Based on the observation that the application of small amounts of exogenous acid sphingomyelinase to generate endogenous ceramide, or provision of exogenous long-chain natural C16-ceramide resulted in rapid translocation of vacuolar daunorubicin into the nucleus in multi-drug resistant (MDR) cells, the present invention relates to a nano-liposomal preparation that includes C16-ceramide. Exposure of MDR cells to the C16:0 ceramide-based nanoliposomes provide a mechanism to reverse MDR in chemoresistant cells and tumors, by inducing rapid translocation of chemotherapeutic agent from cytoplasmic vesicles to the nucleus.

Abstract: A method of maintaining balance in power systems is provided herein. The method comprises of detecting a need for load switch from a source phase to a target phase; then applying a Direct Current (DC) conversion to the target phase, to yield a DC representation of the target phase; then synthesizing the DC representation of the target phase to yield synthesized source phase; then, conveying specified amount of load from the source phase to the synthesized source phase; then, repeatedly advancing, in each cycle, the phase of the synthesized source phase until it breaches the phase of target phase. The advancing is carried out in a rate of up to a standard error deviation that complies with electricity standard and conveying a load from the synthesized source phase to the target phase.