Abstract: Microscopes and methods for processing images of a sample are disclosed. In one implementation, a microscope includes an illumination assembly configured to illuminate the sample under two or more different illumination conditions. The microscope further includes at least one image capture device configured to capture image information associated with the sample and at least one controller. The at least one controller is programmed to receive, from the at least one image capture device, a plurality of images associated with the sample. At least a first portion of the plurality of images is associated with a first region of the sample, and a second portion of the plurality of images is associated with a second region of the sample.