Patents by Inventor Eri Mizuhara

Eri Mizuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GABA neuron progenitor cell marker 65B13
    Patent number: 8609405
    Abstract: The present inventors identified a selective marker 65B13 for GABA neuron progenitor cells of the spinal dorsal horn and cerebellum, and successfully isolated GABA neuron progenitor cells using antibodies that bind to a protein encoded by the gene. 65B13 was demonstrated to be useful as a marker to isolate GABA-producing neuron progenitor cells in the spinal dorsal horn and cerebellum. GABA neuron progenitor cells can be efficiently identified or isolated by using the identified marker as an indicator.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: December 17, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yuichi Ono, Yasuko Nakagawa, Eri Mizuhara
  • Gene specifically expressed in postmitotic dopaminergic neuron precursor cells
    Patent number: 8039224
    Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: October 18, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yasuko Nakagawa, Yuichi Ono, Yoshimasa Sakamoto, Eri Mizuhara, Tomoya Nakatani, Yoshimi Takai
  • METHOD FOR OBTAINING PURKINJE PROGENITOR CELL BY USING NEPH3(65B13) AND E-CADHERIN
    Publication number: 20110201003
    Abstract: 65B13 was discovered to be a useful marker for isolating GABA neuron progenitor cells including Purkinje cells. Furthermore, E-cadherin was revealed to be a useful marker for isolating Purkinje progenitor cells from a 65B13-positive cell population. Specifically, when used in combination with 65B13, E-cadherin was found to be a useful marker for isolating Purkinje progenitor cells.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 18, 2011
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Yuichi Ono, Yasuko Nakagawa, Eri Mizuhara
  • GABA NEURON PROGENITOR CELL MARKER 65B13
    Publication number: 20100303771
    Abstract: The present inventors identified a selective marker 65B13 for GABA neuron progenitor cells of the spinal dorsal horn and cerebellum, and successfully isolated GABA neuron progenitor cells using antibodies that bind to a protein encoded by the gene. 65B13 was demonstrated to be useful as a marker to isolate GABA-producing neuron progenitor cells in the spinal dorsal horn and cerebellum. GABA neuron progenitor cells can be efficiently identified or isolated by using the identified marker as an indicator.
    Type: Application
    Filed: February 7, 2008
    Publication date: December 2, 2010
    Applicant: Eisai R & D Management Co., Ltd.
    Inventors: Yuichi Ono, Yasuko Nakagawa, Eri Mizuhara
  • GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINERGIC NEURON PRECURSOR CELLS
    Publication number: 20100203570
    Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
    Type: Application
    Filed: October 8, 2009
    Publication date: August 12, 2010
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yasuko Nakagawa, Yuichi Ono, Yoshimasa Sakamoto, Eri Mizuhara, Tomoya Nakatani, Yoshimi Takai
  • Methods of isolating dopaminergic neuron precursor cells
    Patent number: 7622270
    Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
    Type: Grant
    Filed: October 21, 2003
    Date of Patent: November 24, 2009
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yasuko Nakagawa, Yuichi Ono, Yoshimasa Sakamoto, Eri Mizuhara, Tomoya Nakatani, Yoshimi Takai
  • GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINERGIC NEURON PRECURSOR CELLS
    Publication number: 20070122882
    Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
    Type: Application
    Filed: January 11, 2007
    Publication date: May 31, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Yasuko Nakagawa, Yuichi Ono, Yoshimasa Sakamoto, Eri Mizuhara, Tomoya Nakatani, Yoshimi Takai
  • Gene expressed specifically in dopamine-producing neuron precursor cells after termination of division
    Publication number: 20060239978
    Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
    Type: Application
    Filed: October 21, 2003
    Publication date: October 26, 2006
    Applicant: EISAI CO., LTD.
    Inventors: Yasuko Nakagawa, Yuichi Ono, Yoshima Sakamoto, Eri Mizuhara, Tomoya Nakatani, Yoshimi Takai