Patents by Inventor Eric A. Murphy

Eric A. Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • [1,2,4]thiadiazine 1,1-dioxide compounds
    Patent number: 8097613
    Abstract: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: January 17, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Peter Dragovich, Stephen E. Webber, Douglas Eric Murphy, Chinh Viet Tran
  • Pyrazole glucokinase activators
    Patent number: 7935699
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: May 3, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Ramakanth Sarabu, Chinh Viet Tran, Dionisios Vourloumis
  • Oxime glucokinase activators
    Patent number: 7902248
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 8, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Chinh Viet Tran, Dionisios Vourloumis
  • Pyrro[1,2-]pyridazinone intermediates
    Patent number: 7842838
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: November 30, 2010
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Eric Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • PROTEIN KINASE MODULATING COMPOUNDS AND METHODS FOR MAKING AND USING THEM
    Publication number: 20100209488
    Abstract: The invention provides compositions, e.g., small molecules, that disrupt the activity of protein kinases, including constitutively activated protein kinases, such as kinases constitutively activated through mutations, and kinases in their native inactivated state, and methods for making and using them. In one aspect, compositions of the invention bind a protein kinase in its inactive conformation involving the conserved asparagine-phenylalanine-glycine residue motif, or “Asp-Phe-Gly” or “DFG” motif, of the activation loop in the allosteric binding site. The small molecule protein kinase inhibitors of the invention comprise or are derivatives or analogs of oxadiazoles, thiadiazoles, oxazoles, thiazoles, arylamides, quinolones, pyrazoles, pyrazolones, imides, pyrolles, imidazoles and/or triazoles.
    Type: Application
    Filed: July 15, 2008
    Publication date: August 19, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wolfgang Wrasidlo, Eric Murphy, David Cheresh
  • Diacylglycerol acyltransferases from flax
    Publication number: 20090249516
    Abstract: The invention relates to isolated diacylglycerol acyltransferases and polynucleotide sequences encoding the DGAT enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same. Also provided are transformed cells and transgenic plants, especially Camelina sativa plant, with enhanced oil accumulation and quality.
    Type: Application
    Filed: March 9, 2009
    Publication date: October 1, 2009
    Applicants: University of Alberta, Agru-Food
    Inventors: Randall Weselake, Rodrigo Siloto, Qin Liu, Andre Laroche, Eric Murphy, Kimmo Koivu
  • Pyrro[1,2-]pyridazinone compounds
    Patent number: 7582754
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: September 1, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Eric Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • Oxime glucokinase activators
    Publication number: 20080146625
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 19, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Chinh Viet Tran, Dionisios Vourloumis
  • Pyrazole glucokinase activators
    Publication number: 20080021032
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
    Type: Application
    Filed: July 19, 2007
    Publication date: January 24, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Ramakanth Sarabu, Chinh Viet Tran, Dionisios Vourloumis
  • Methods and compositions for multiplex amplification of nucleic acids
    Patent number: 7053206
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 30, 2006
    Assignee: Affymetrix, Inc.
    Inventors: Hajime Matsuzaki, Eric Murphy
  • Methods and compositions for multiplex amplification of nucleic acids
    Publication number: 20050112657
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 26, 2005
    Applicant: AFFYMETRIX, INC
    Inventors: Haiime Matsuzaki, Eric Murphy
  • Methods and compositions for multiplex amplification of nucleic acids
    Publication number: 20040126806
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 1, 2004
    Applicant: AFFYMETRIX, INC.
    Inventors: Hajime Matsuzaki, Eric A. Murphy
  • Methods and compositions for multiplex amplification of nucleic acids
    Patent number: 6673579
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: January 6, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Hajime Matsuzaki, Eric Murphy
  • Methods and compositions for multiplex amplification of nucleic acids
    Publication number: 20020058281
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Application
    Filed: November 21, 2001
    Publication date: May 16, 2002
    Applicant: AFFYMETRIX, INC.
    Inventors: Hajime Matsuzaki, Eric A. Murphy
  • Methods and compositions for multiplex amplification of nucleic acids
    Patent number: 6333179
    Abstract: A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: December 25, 2001
    Assignee: Affymetrix, Inc.
    Inventors: Hajime Matsuzaki, Eric A. Murphy